Adam H Metherel

Affiliations

Department of Nutritional Sciences, University of Toronto, Toronto, ON M5S 1A8, Canada. Electronic address: adam.metherel@utoronto.ca.

Publications (33)

Updates to the n-3 polyunsaturated fatty acid biosynthesis pathway: DHA synthesis rates, tetracosahexaenoic acid and (minimal) retroconversion.

Progress in lipid research

Avec: Adam H Metherel , Richard P Bazinet

Brain eicosapentaenoic acid metabolism as a lead for novel therapeutics in major depression.

Brain, behavior, and immunity

Avec: Richard P Bazinet , Adam H Metherel , Chuck T Chen , Saame Raza Shaikh , Agnes Nadjar , Corinne Joffre , Sophie Layé

DHA Esterified to Phosphatidylserine or Phosphatidylcholine is More Efficient at Targeting the Brain than DHA Esterified to Triacylglycerol.

Molecular nutrition & food research

Avec: Raphaël Chouinard-Watkins , R J Scott Lacombe , Adam H Metherel , Mojgan Masoodi , Richard P Bazinet

Do Eicosapentaenoic Acid and Docosahexaenoic Acid Have the Potential to Compete against Each Other?

Nutrients

Avec: Anandita Pal , Adam H Metherel , Lauren Fiabane , Nicole Buddenbaum , Richard P Bazinet , Saame Raza Shaikh

Increases in plasma n-3 tetracosapentaenoic acid and tetracosahexaenoic acid following 12 weeks of EPA, but not DHA, supplementation in women and men.

Prostaglandins, leukotrienes, and essential fatty acids

Avec: Ruxandra D Rotarescu , Kimia Rezaei , David M Mutch , Adam H Metherel

Effects of menopausal hormone therapy on erythrocyte n-3 and n-6 PUFA concentrations in the Women's Health Initiative randomized trial.

The American journal of clinical nutrition

Avec: William S Harris , Nathan L Tintle , JoAnn E Manson , Adam H Metherel , Jennifer G Robinson

Plasma unesterified eicosapentaenoic acid is converted to docosahexaenoic acid (DHA) in the liver and supplies the brain with DHA in the presence or absence of dietary DHA.

Biochimica et biophysica acta. Molecular and cell biology of lipids

Avec: Adam H Metherel , Kimia Rezaei , R J Scott Lacombe , Richard P Bazinet

Effects of hypercapnia / ischemia and dissection on the rat brain metabolome.

Neurochemistry international

Avec: Duncan A Sylvestre , Yurika Otoki , Adam H Metherel , Richard P Bazinet , Carolyn M Slupsky , Ameer Y Taha

Sex-dependent differences in tissue and blood n-3 PUFA levels following ALA or ALA + DHA feeding of liver-specific Elovl2-KO and control mice.

Prostaglandins, leukotrienes, and essential fatty acids

Avec: Kuorosh Rezaei , Ashley M Bejoy , Ruxandra D Rotarescu , Brinley J Klievik , Adam H Metherel

Serum measures of docosahexaenoic acid (DHA) synthesis underestimates whole body DHA synthesis in male and female mice.

The Journal of nutritional biochemistry

Avec: Ruxandra D Rotarescu , Mahima Mathur , Ashley Bejoy , G Harvey Anderson , Adam H Metherel

Acute Hypercapnia/Ischemia Alters the Esterification of Arachidonic Acid and Docosahexaenoic Acid Epoxide Metabolites in Rat Brain Neutral Lipids.

Lipids

Avec: Yurika Otoki , Adam H Metherel , Theresa Pedersen , Jun Yang , Bruce D Hammock , Richard P Bazinet , John W Newman , Ameer Y Taha

EPA and DHA have divergent effects on serum triglycerides and lipogenesis, but similar effects on lipoprotein lipase activity: a randomized controlled trial.

The American journal of clinical nutrition

Avec: Shannon L Klingel , Adam H Metherel , Maha Irfan , Alex Rajna , Adrian Chabowski , Richard P Bazinet , David M Mutch

Docosahexaenoic acid is both a product of and a precursor to tetracosahexaenoic acid in the rat.

Journal of lipid research

Avec: Adam H Metherel , R J Scott Lacombe , Raphaël Chouinard-Watkins , Richard P Bazinet

Serum lipid analysis and isotopic enrichment is suggestive of greater lipogenesis in young long-term cannabis users: A secondary analysis of a case-control study.

Lipids

Avec: Giulia Cisbani , Alex Koppel , Adam H Metherel , Mackenzie E Smith , Kankana N Aji , Ana C Andreazza , Romina Mizrahi , Richard P Bazinet

Influence of the nutritional status and oxidative stress in the desaturation and elongation of n-3 and n-6 polyunsaturated fatty acids: Impact on non-alcoholic fatty liver disease.

Prostaglandins, leukotrienes, and essential fatty acids

Avec: Luis A Videla , Maria Catalina Hernandez-Rodas , Adam H Metherel , Rodrigo Valenzuela

Novel

Journal of lipid research

Avec: Brinley J Klievik , Adam H Metherel , Giulia Cisbani , Rodrigo Valenzuela , Richard P Bazinet

Blood and tissue docosahexaenoic acid (DHA, 22:6n-3) turnover rates from Ahiflower® oil are not different than from DHA ethyl ester oil in a diet switch mouse model.

Biochimica et biophysica acta. Molecular and cell biology of lipids

Avec: Adam H Metherel , Brinley J Klievik , Giulia Cisbani , Mackenzie E Smith , Greg Cumberford , Richard P Bazinet

Nonesterified Fatty Acids and Depression in Cancer Patients and Caregivers.

Current developments in nutrition

Avec: Megan R McCusker , Richard P Bazinet , Adam H Metherel , Roberta Yael Klein , Arjun Kundra , Benjamin Haibe-Kains , Madeline Li

Compound-specific isotope analysis reveals no retroconversion of DHA to EPA but substantial conversion of EPA to DHA following supplementation: a randomized control trial.

The American journal of clinical nutrition

Avec: Adam H Metherel , Maha Irfan , Shannon L Klingel , David M Mutch , Richard P Bazinet

Brain oxylipin concentrations following hypercapnia/ischemia: effects of brain dissection and dissection time.

Journal of lipid research

Avec: Marie Hennebelle , Adam H Metherel , Alex P Kitson , Yurika Otoki , Jun Yang , Kin Sing Stephen Lee , Bruce D Hammock , Richard P Bazinet , Ameer Y Taha

Interlaboratory Assessment of Dried Blood Spot Fatty Acid Compositions.

Lipids

Avec: Adam H Metherel , William S Harris , Liu Ge , Robert A Gibson , Raphaël Chouinard-Watkins , Richard P Bazinet , Lei Liu , J Thomas Brenna , Juan J Aristizabal-Henao , Ken D Stark , Robert C Block

Murine and human microglial cells are relatively enriched with eicosapentaenoic acid compared to the whole brain.

Neurochemistry international

Avec: Giulia Cisbani , Adam H Metherel , Mackenzie E Smith , Richard P Bazinet

Analysis of omega-3 and omega-6 polyunsaturated fatty acid metabolism by compound-specific isotope analysis in humans.

Journal of lipid research

Avec: Daniel K Chen , Adam H Metherel , Kimia Rezaei , Camilla Parzanini , Chuck T Chen , Christopher E Ramsden , Mark Horowitz , Keturah R Faurot , Beth MacIntosh , Daisy Zamora , Richard P Bazinet

Protein concentrations and activities of fatty acid desaturase and elongase enzymes in liver, brain, testicle, and kidney from mice: Substrate dependency.

BioFactors (Oxford, England)

Avec: Rodrigo Valenzuela , Adam H Metherel , Giulia Cisbani , Mackenzie E Smith , Raphaël Chouinard-Watkins , Brinley J Klievik , Luis A Videla , Richard P Bazinet

DHA Cycling Halves the DHA Supplementation Needed to Maintain Blood and Tissue Concentrations via Higher Synthesis from ALA in Long-Evans Rats.

The Journal of nutrition

Avec: Adam H Metherel , Maha Irfan , Raphaël Chouinard-Watkins , Marc-Olivier Trépanier , Ken D Stark , Richard P Bazinet

The majority of brain palmitic acid is maintained by lipogenesis from dietary sugars and is augmented in mice fed low palmitic acid levels from birth.

Journal of neurochemistry

Avec: Mackenzie E Smith , Giulia Cisbani , Adam H Metherel , Richard P Bazinet

Hepatic Igf1-Deficiency Protects Against Atherosclerosis in Female Mice.

Endocrinology

Avec: Tharini Sivasubramaniyam , Jiaqi Yang , Evan Pollock , Joseph Chon , Stephanie A Schroer , Yu Zhe Li , Adam H Metherel , David W Dodington , Richard P Bazinet , Minna Woo

Effect of Storage Conditions on the Quality of Arbequina Extra Virgin Olive Oil and the Impact on the Composition of Flavor-Related Compounds (Phenols and Volatiles).

Foods (Basel, Switzerland)

Avec: Leeanny Caipo , Ana Sandoval , Betsabet Sepúlveda , Edwar Fuentes , Rodrigo Valenzuela , Adam H Metherel , Nalda Romero

Higher Increase in Plasma DHA in Females Compared to Males Following EPA Supplementation May Be Influenced by a Polymorphism in ELOVL2: An Exploratory Study.

Lipids

Avec: Adam H Metherel , Maha Irfan , Shannon L Klingel , David M Mutch , Richard P Bazinet

Dietary docosahexaenoic acid (DHA) downregulates liver DHA synthesis by inhibiting eicosapentaenoic acid elongation.

Journal of lipid research

Avec: Adam H Metherel , Rodrigo Valenzuela , Brinley J Klievik , Giulia Cisbani , Ruxandra D Rotarescu , Melissa Gonzalez-Soto , Céline Cruciani-Guglielmacci , Sophie Layé , Christophe Magnan , David M Mutch , Richard P Bazinet

The omega-3 hydroxy fatty acid 7(

Science signaling

Avec: Jiabao Liu , Cigdem Sahin , Samar Ahmad , Lilia Magomedova , Minhao Zhang , Zhengping Jia , Adam H Metherel , Arturo Orellana , Gennady Poda , Richard P Bazinet , Liliana Attisano , Carolyn L Cummins , Hui Peng , Henry M Krause

Dietary triacetin, but not medium chain triacylglycerides, blunts weight gain in diet-induced rat model of obesity.

Lipids

Avec: Giulia Cisbani , Raphaël Chouinard-Watkins , Mackenzie E Smith , Arezou Malekanian , Rodrigo Valenzuela , Adam H Metherel , Richard P Bazinet

Omega-3 Polyunsaturated Fatty Acids with Adipose Tissue Inflammation: Longitudinal Analysis in the PROMISE Cohort.

The Journal of clinical endocrinology and metabolism

Avec: Ji-Eun Chon , Zhila Semnani-Azad , Kira Z H Lai , Phillip W Connelly , Ravi Retnakaran , Stewart B Harris , Adam H Metherel , David J A Jenkins , Richard P Bazinet , Anthony J Hanley

Réseau de co-auteurs

Richard P Bazinet 27 collaborations

Giulia Cisbani 8 collaborations

Raphaël Chouinard-Watkins 6 collaborations

Mackenzie E Smith 6 collaborations

Rodrigo Valenzuela 6 collaborations

David M Mutch 5 collaborations

Brinley J Klievik 5 collaborations

Ruxandra D Rotarescu 4 collaborations

Maha Irfan 4 collaborations

R J Scott Lacombe 3 collaborations

Kimia Rezaei 3 collaborations

Yurika Otoki 3 collaborations

Ameer Y Taha 3 collaborations

Shannon L Klingel 3 collaborations

Chuck T Chen 2 collaborations

Saame Raza Shaikh 2 collaborations

Sophie Layé 2 collaborations

William S Harris 2 collaborations

Jun Yang 2 collaborations

Bruce D Hammock 2 collaborations

Luis A Videla 2 collaborations

Ken D Stark 2 collaborations

Agnes Nadjar 1 collaboration

Corinne Joffre 1 collaboration

Mojgan Masoodi 1 collaboration

Anandita Pal 1 collaboration

Lauren Fiabane 1 collaboration

Nicole Buddenbaum 1 collaboration

Nathan L Tintle 1 collaboration

JoAnn E Manson 1 collaboration

Jennifer G Robinson 1 collaboration

Duncan A Sylvestre 1 collaboration

Carolyn M Slupsky 1 collaboration

Kuorosh Rezaei 1 collaboration

Ashley M Bejoy 1 collaboration

Mahima Mathur 1 collaboration

Ashley Bejoy 1 collaboration

G Harvey Anderson 1 collaboration

Theresa Pedersen 1 collaboration

John W Newman 1 collaboration

Alex Rajna 1 collaboration

Adrian Chabowski 1 collaboration

Alex Koppel 1 collaboration

Kankana N Aji 1 collaboration

Ana C Andreazza 1 collaboration

Romina Mizrahi 1 collaboration

Maria Catalina Hernandez-Rodas 1 collaboration

Greg Cumberford 1 collaboration

Megan R McCusker 1 collaboration

Roberta Yael Klein 1 collaboration

Arjun Kundra 1 collaboration

Benjamin Haibe-Kains 1 collaboration

Madeline Li 1 collaboration

Marie Hennebelle 1 collaboration

Alex P Kitson 1 collaboration

Kin Sing Stephen Lee 1 collaboration

Liu Ge 1 collaboration

Robert A Gibson 1 collaboration

Lei Liu 1 collaboration

J Thomas Brenna 1 collaboration

Juan J Aristizabal-Henao 1 collaboration

Robert C Block 1 collaboration

Daniel K Chen 1 collaboration

Camilla Parzanini 1 collaboration

Christopher E Ramsden 1 collaboration

Mark Horowitz 1 collaboration

Keturah R Faurot 1 collaboration

Beth MacIntosh 1 collaboration

Daisy Zamora 1 collaboration

Marc-Olivier Trépanier 1 collaboration

Tharini Sivasubramaniyam 1 collaboration

Jiaqi Yang 1 collaboration

Evan Pollock 1 collaboration

Joseph Chon 1 collaboration

Stephanie A Schroer 1 collaboration

Yu Zhe Li 1 collaboration

David W Dodington 1 collaboration

Minna Woo 1 collaboration

Leeanny Caipo 1 collaboration

Ana Sandoval 1 collaboration

Betsabet Sepúlveda 1 collaboration

Edwar Fuentes 1 collaboration

Nalda Romero 1 collaboration

Melissa Gonzalez-Soto 1 collaboration

Céline Cruciani-Guglielmacci 1 collaboration

Christophe Magnan 1 collaboration

Jiabao Liu 1 collaboration

Cigdem Sahin 1 collaboration

Samar Ahmad 1 collaboration

Lilia Magomedova 1 collaboration

Minhao Zhang 1 collaboration

Zhengping Jia 1 collaboration

Arturo Orellana 1 collaboration

Gennady Poda 1 collaboration

Liliana Attisano 1 collaboration

Carolyn L Cummins 1 collaboration

Hui Peng 1 collaboration

Henry M Krause 1 collaboration

Arezou Malekanian 1 collaboration

Ji-Eun Chon 1 collaboration

Zhila Semnani-Azad 1 collaboration

Kira Z H Lai 1 collaboration

Phillip W Connelly 1 collaboration

Ravi Retnakaran 1 collaboration

Stewart B Harris 1 collaboration

David J A Jenkins 1 collaboration

Anthony J Hanley 1 collaboration