The omega-3 hydroxy fatty acid 7(

Animals Mice Rats Brain / metabolism Fatty Acids, Omega-3 Ligands Neurons / metabolism PPAR alpha / genetics

Journal

Science signaling
ISSN: 1937-9145
Titre abrégé: Sci Signal
Pays: United States
ID NLM: 101465400

Informations de publication

Date de publication:
05 07 2022
Historique:
entrez: 20 7 2022
pubmed: 21 7 2022
medline: 23 7 2022
Statut: ppublish

Résumé

The nuclear receptor peroxisome proliferator-activated receptor alpha (PPARα) is emerging as an important target in the brain for the treatment or prevention of cognitive disorders. The identification of high-affinity ligands for brain PPARα may reveal the mechanisms underlying the synaptic effects of this receptor and facilitate drug development. Here, using an affinity purification-untargeted mass spectrometry (AP-UMS) approach, we identified an endogenous, selective PPARα ligand, 7(

Identifiants

DOI: 10.1126/scisignal.abo1857 PMID: 35857636
pubmed: 35857636
doi: 10.1126/scisignal.abo1857
doi:

Substances chimiques

Fatty Acids, Omega-3 0
Ligands 0
PPAR alpha 0
7(S)-hydroxy-docosahexaenoic acid 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

eabo1857

Subventions

Organisme : CIHR
ID : OME-142884
Pays : Canada
Organisme : CIHR
ID : PJT-156159
Pays : Canada
Organisme : CIHR
ID : FRN-148455
Pays : Canada
Organisme : CIHR
ID : MOP119421
Pays : Canada
Organisme : CIHR
ID : PJT-155959
Pays : Canada

Auteurs

Jiabao Liu (J)

Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON M5S 3E1, Canada.
ORCID: 0000-0002-5440-1841

Cigdem Sahin (C)

Department of Pharmaceutical Sciences, University of Toronto, Toronto, ON M5S 3M2, Canada.

Samar Ahmad (S)

Department of Biochemistry, University of Toronto, Toronto, ON M5S 3E2.
ORCID: 0000-0001-5015-6431

Lilia Magomedova (L)

Department of Pharmaceutical Sciences, University of Toronto, Toronto, ON M5S 3M2, Canada.

Minhao Zhang (M)

Department of Chemistry, York University, Toronto, ON M3J 1P3, Canada.

Zhengping Jia (Z)

Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada.
Department of Physiology, University of Toronto, Toronto, ON M5S 1A8, Canada.

Adam H Metherel (AH)

Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, ON, Canada.

Arturo Orellana (A)

Department of Chemistry, York University, Toronto, ON M3J 1P3, Canada.
ORCID: 0000-0002-8372-2222

Gennady Poda (G)

Department of Pharmaceutical Sciences, University of Toronto, Toronto, ON M5S 3M2, Canada.
Drug Discovery, Ontario Institute for Cancer Research, Toronto, ON M5G 0A3, Canada.

Richard P Bazinet (RP)

Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, ON, Canada.

Liliana Attisano (L)

Department of Biochemistry, University of Toronto, Toronto, ON M5S 3E2.
ORCID: 0000-0003-4824-2642

Carolyn L Cummins (CL)

Department of Pharmaceutical Sciences, University of Toronto, Toronto, ON M5S 3M2, Canada.
ORCID: 0000-0001-7603-6577

Hui Peng (H)

Department of Chemistry, University of Toronto, Toronto, ON M5S 3H6, Canada.
School of the Environment, University of Toronto, Toronto, ON M5S 3H6, Canada.
ORCID: 0000-0002-2000-1647

Henry M Krause (HM)

Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON M5S 3E1, Canada.
Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada.
ORCID: 0000-0002-6182-7074

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › The omega-3 hydroxy fatty acid 7(
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › The omega-3 hydroxy fatty acid 7(
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › The omega-3 hydroxy fatty acid 7(
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › The omega-3 hydroxy fatty acid 7(
questionsmedicales.fr › Lipides › Huiles › Huiles de poisson › Acides gras omega-3 › The omega-3 hydroxy fatty acid 7(
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Produits chimiques de laboratoire › Ligands › The omega-3 hydroxy fatty acid 7(
questionsmedicales.fr › Cellules › Neurones › The omega-3 hydroxy fatty acid 7(
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Récepteurs cytoplasmiques et nucléaires › Récepteur PPAR alpha › The omega-3 hydroxy fatty acid 7(