Role of specific IgE on staphylococcal enterotoxin B in chronic rhinosinusitis severity.
endotype
enterotoxin
nasal polyp
rhinosinusitis
staphylococcus
Journal
Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery
ISSN: 1749-4486
Titre abrégé: Clin Otolaryngol
Pays: England
ID NLM: 101247023
Informations de publication
Date de publication:
Mar 2021
Mar 2021
Historique:
received:
30
07
2020
revised:
15
09
2020
accepted:
03
10
2020
pubmed:
12
11
2020
medline:
15
12
2021
entrez:
11
11
2020
Statut:
ppublish
Résumé
To investigate the clinical significance of specific IgE-staphylococcal enterotoxin B (IgE-SEB) in CRS (chronic rhinosinusitis). Retrospective analysis of patients who were positive for specific IgE-staphylococcal enterotoxin B. Tertiary rhinology clinic. A total of 965 patients who were tested for specific IgE-staphylococcal enterotoxin B from December 2016 to December 2017. We retrospectively reviewed the records of 965 patients who were tested for specific IgE-staphylococcal enterotoxin B from December 2016 to December 2017. Patient demographics, titre-specific IgE to staphylococcal enterotoxin B levels, MAST, serologic test and medical records were reviewed. IgE-SEB (KU/L) was higher in CRS patients than non-CRS patients (0.13 ± 0.37 vs 0.08 ± 0.22, respectively; P-value: .044), and the IgE-SEB (+, ≥0.35) rate was also higher (10.06% vs 4.46%, respectively; P-value: .030). IgE-SEB (KU/L) was higher in the CRS group than in the fungal sinusitis group (0.13 ± 0.37 vs 0.03 ± 0.05, respectively; P-value: <.001), and the IgE-SEB (+, ≥0.35) rate was also higher (10.06% vs 0%, respectively; P-value: .015). Between the CRSsNP (chronic rhinosinusitis without nasal polyps) and CRSwNP (chronic rhinosinusitis with nasal polyps) groups, there were no differences in IgE-SEB (KU/L) or IgE-SEB (+) rates. IgE-SEB positivity was not associated with the presence of polyps, concomitant asthma or postoperative recurrence. As the values of IgE-SEB (KU/L) and the IgE-SEB (+, >0.1) rate increased, the CRS severity also increased. IgE-SEB showed a positive correlation with Lund-Mackay CT severity score, but not with postoperative recurrence or nasal polyps. Further studies are needed to obtain clear evidence that IgE-SEB can be considered as an independent CRS endotype.
Substances chimiques
Enterotoxins
0
Immunoglobulin E
37341-29-0
enterotoxin B, staphylococcal
39424-53-8
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
304-310Subventions
Organisme : National Research Foundation of Korea
ID : NRF-2016M3A9D5A01952414
Organisme : National Research Foundation of Korea
ID : NRF-2018R1D1A1A02049236
Informations de copyright
© 2020 John Wiley & Sons Ltd.
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