Ring Finger Protein 11 (RNF11) Modulates Dopamine Release in Drosophila.
Drosophila
Parkinson disease
RNF11
dopamine
dopamine transporter
voltammetry
Journal
Neuroscience
ISSN: 1873-7544
Titre abrégé: Neuroscience
Pays: United States
ID NLM: 7605074
Informations de publication
Date de publication:
01 01 2021
01 01 2021
Historique:
received:
06
07
2020
revised:
15
10
2020
accepted:
18
10
2020
pubmed:
12
11
2020
medline:
15
5
2021
entrez:
11
11
2020
Statut:
ppublish
Résumé
Recent work indicates a role for RING finger protein 11 (RNF11) in Parkinson disease (PD) pathology, which involves the loss of dopaminergic neurons. However, the role of RNF11 in regulating dopamine neurotransmission has not been studied. In this work, we tested the effect of RNF11 RNAi knockdown or overexpression on stimulated dopamine release in the larval Drosophila central nervous system. Dopamine release was stimulated using optogenetics and monitored in real-time using fast-scan cyclic voltammetry at an electrode implanted in an isolated ventral nerve cord. RNF11 knockdown doubled dopamine release, but there was no decrease in dopamine from RNF11 overexpression. RNF11 knockdown did not significantly increase stimulated serotonin or octopamine release, indicating the effect is dopamine specific. Dopamine clearance was also changed, as RNF11 RNAi flies had a higher V
Identifiants
pubmed: 33176188
pii: S0306-4522(20)30681-3
doi: 10.1016/j.neuroscience.2020.10.021
pmc: PMC7769989
mid: NIHMS1649378
pii:
doi:
Substances chimiques
DNA-Binding Proteins
0
Dopamine Plasma Membrane Transport Proteins
0
Drosophila Proteins
0
RNF11 protein, human
0
Serotonin
333DO1RDJY
Dopamine
VTD58H1Z2X
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
37-48Subventions
Organisme : NIMH NIH HHS
ID : R01 MH085159
Pays : United States
Informations de copyright
Copyright © 2020 IBRO. Published by Elsevier Ltd. All rights reserved.
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