Treg-dependent immunosuppression triggers effector T cell dysfunction via the STING/ILC2 axis.
A549 Cells
Animals
CD8-Positive T-Lymphocytes
/ immunology
Cell Line, Tumor
GATA3 Transcription Factor
/ metabolism
Humans
Immune Tolerance
/ immunology
Immunity, Innate
/ immunology
Lung Neoplasms
/ pathology
Male
Membrane Proteins
/ antagonists & inhibitors
Mice
Mice, Inbred C57BL
Mitochondria
/ metabolism
Neoplasm Transplantation
Nitric Oxide Synthase Type II
/ metabolism
Proto-Oncogene Proteins p21(ras)
/ metabolism
Reactive Oxygen Species
/ metabolism
T-Lymphocytes, Regulatory
/ immunology
Transplantation, Heterologous
Tumor Microenvironment
/ immunology
AICD
ILC2
Immunosuppression
Kras
STING
Treg
Journal
Clinical immunology (Orlando, Fla.)
ISSN: 1521-7035
Titre abrégé: Clin Immunol
Pays: United States
ID NLM: 100883537
Informations de publication
Date de publication:
01 2021
01 2021
Historique:
received:
23
09
2020
revised:
02
11
2020
accepted:
02
11
2020
pubmed:
12
11
2020
medline:
17
6
2021
entrez:
11
11
2020
Statut:
ppublish
Résumé
Lung cancer remains the leading cause of cancer-related deaths and despite extensive research, the survival rate of lung cancer patients remains significantly low. Recent data reveal that aberrant Kras signaling drives regulatory T cells (Tregs) present in lung tumor microenvironment to establish immune deregulation and immunosuppression but the exact pathogenic mechanism is still unknown. In this study, we investigate the role of oncogenic Kras in Treg-related immunosuppression and its involvement in tumor-associated metabolic reprogramming. Findings reveal Tregs to prompt GATA3/NOS2-related immunosuppression via STING inhibition which triggers a decline in CD4
Identifiants
pubmed: 33176208
pii: S1521-6616(20)30780-4
doi: 10.1016/j.clim.2020.108620
pii:
doi:
Substances chimiques
GATA3 Transcription Factor
0
GATA3 protein, human
0
KRAS protein, human
0
Membrane Proteins
0
Reactive Oxygen Species
0
STING1 protein, human
0
NOS2 protein, human
EC 1.14.13.39
Nitric Oxide Synthase Type II
EC 1.14.13.39
Proto-Oncogene Proteins p21(ras)
EC 3.6.5.2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
108620Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.