Outcome of Bleb Revision With Autologous Conjunctival Graft Alone or Combined With Donor Scleral Graft for Late-onset Bleb Leakage With Hypotony After Standard Trabeculectomy With Mitomycin C.


Journal

Journal of glaucoma
ISSN: 1536-481X
Titre abrégé: J Glaucoma
Pays: United States
ID NLM: 9300903

Informations de publication

Date de publication:
01 02 2021
Historique:
received: 05 05 2020
accepted: 03 10 2020
pubmed: 13 11 2020
medline: 4 9 2021
entrez: 12 11 2020
Statut: ppublish

Résumé

Treatment of leakage with ocular hypotony after trabeculectomy with mitomycin C (MMC) can be safely achieved through conjunctival patch alone or combined with donor scleral graft in cases of melted underlying sclera. To report outcomes of 2 surgical approaches for treating ocular hypotony in eyes with blebs with late-onset leakage after standard trabeculectomy with MMC. Thirty consecutive cases with bleb leakage and hypotony underwent bleb revision surgery between 2009 and 2014 by the same surgeon (J.W.) at the Department of Ophthalmology of the Mainz University Medical Center, Germany. In 18 patients, an autologous conjunctival patch graft was applied. In 12 patients, the underlying sclera was found melted and an additional scleral donor graft was sutured in place. The authors analyzed intraocular pressure, visual acuity, and optical coherence tomography of the macula preoperatively at 1 day, 1 week, 4 weeks, and 6 months after surgery. The mean IOP was 6.2±3.5 mm Hg preoperatively and 21.7±16.4 mm Hg at 1 day, 13.7±6.7 at 1 week, 13.1±5.1 mm Hg at 4 weeks, and 12.1±4.7 mm Hg at 6 months after surgery. Visual acuity (logMar) increased from 0.57±0.49 preoperatively to 0.49±0.40 at 6 months. Optical coherence tomography showed flattening of macular folds that were present before treatment. No serious adverse event was reported. This revision technique with conjunctival patch and/or additional donor scleral graft is an effective and safe method for treating late bleb leakage and hypotony maculopathy after trabeculectomy with MMC.

Identifiants

pubmed: 33177366
pii: 00061198-202102000-00010
doi: 10.1097/IJG.0000000000001740
doi:

Substances chimiques

Mitomycin 50SG953SK6

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

175-179

Commentaires et corrections

Type : CommentIn
Type : CommentIn

Informations de copyright

Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.

Déclaration de conflit d'intérêts

Disclosure: The authors declare no conflict of interest.

Références

Higginbotham EJ, Alexis D. Is newer necessarily better? The evolution of incisional glaucoma surgery over the last 100 years. Am J Ophthalmol. 2018;191:xxv–xxix.
Greenfield DS, Liebmann JM, Jee J, et al. Late-onset bleb leaks after glaucoma filtering surgery. Arch Ophthalmol. 1998;116:443–447.
Thomas M, Vajaranant TS, Aref AA. Hypotony maculopathy: clinical presentation and therapeutic methods. Ophthalmol Ther. 2015;4:79–88.
Luebke J, Neuburger M, Jordan JF, et al. Bleb-related infections and long-term follow-up after trabeculectomy. Int Ophthalmol. 2019;39:571–577.
Nuyts RM, Greve EL, Geijssen HC, et al. Treatment of hypotonous maculopathy after trabeculectomy with mitomycin C. Am J Ophthalmol. 1994;118:322–331.
Dinah C, Bhachech B, Ghosh G. Long-term success with autologous blood injection for leaking trabeculectomy blebs. Br J Ophthalmol. 2010;94:392–393.
Budenz DL, Barton K, Tseng SC. Amniotic membrane transplantation for repair of leaking glaucoma filtering blebs. Am J Ophthalmol. 2000;130:580–588.
Schnyder CC, Shaarawy T, Ravinet E, et al. Free conjunctival autologous graft for bleb repair and bleb reduction after trabeculectomy and nonpenetrating filtering surgery. J Glaucoma. 2002;11:10–16.
Harizman N, Ben-Cnaan R, Goldenfeld M, et al. Donor scleral patch for treating hypotony due to leaking and/or overfiltering blebs. J Glaucoma. 2005;14:492–496.
Bochmann F, Kaufmann C, Kipfer A, et al. Corneal patch graft for the repair of late-onset hypotony or filtering bleb leak after trabeculectomy: a new surgical technique. J Glaucoma. 2014;23:e76–e80.
Pfeiffer N, Grehn F. Improved suture for fornix-based conjunctival flap in filtering surgery. Int Ophthalmol. 1992;16:391–396.
Kosmin AS, Wishart PK. A full-thickness scleral graft for the surgical management of a late filtration bleb leak. Ophthalmic Surg Lasers. 1997;28:461–468.
Laspas P, Culmann PD, Grus FH, et al. A new method for revision of encapsulated blebs after trabeculectomy: combination of standard bleb needling with transconjunctival scleral flap sutures prevents early postoperative hypotony. PLoS One. 2016;11:e0157320.
Panday M, Shantha B, George R, et al. Outcomes of bleb excision with free autologous conjunctival patch grafting for bleb leak and hypotony after glaucoma filtering surgery. J Glaucoma. 2011;20:392–397.
Xu JG, Zhong J, Yang YF, et al. Efficacy of autologous conjunctival flap on repairing the late-onset filtering bleb leakage. Int J Ophthalmol. 2018;11:601–606.
Tannenbaum DP, Hoffman D, Greaney MJ, et al. Outcomes of bleb excision and conjunctival advancement for leaking or hypotonous eyes after glaucoma filtering surgery. Br J Ophthalmol. 2004;88:99–103.
Prokosch-Willing V, Lamparter J, Ul Hassan SN, et al. Results of an adaptive surgical approach for managing late onset hypotony after trabeculectomy with mitomycin C. J Glaucoma. 2018;27:307–314.
Feldman RM, Altaher G. Management of late-onset bleb leaks. Curr Opin Ophthalmol. 2004;15:151–154.
Henderson HW, Ezra E, Murdoch IE. Early postoperative trabeculectomy leakage: incidence, time course, severity, and impact on surgical outcome. Br J Ophthalmol. 2004;88:626–629.
Parrish RK 2nd, Schiffman JC, Feuer WJ, et al. Prognosis and risk factors for early postoperative wound leaks after trabeculectomy with and without 5-fluorouracil. Am J Ophthalmol. 2001;132:633–640.
Alwitry A, Rotchford A, Patel V, et al. Early bleb leak after trabeculectomy and prognosis for bleb failure. Eye (Lond). 2009;23:858–863.
Hu CY, Matsuo H, Tomita G, et al. Clinical characteristics and leakage of functioning blebs after trabeculectomy with mitomycin-C in primary glaucoma patients. Ophthalmology. 2003;110:345–352.
Matsuo H, Tomidokoro A, Suzuki Y, et al. Late-onset transconjunctival oozing and point leak of aqueous humor from filtering bleb after trabeculectomy. Am J Ophthalmol. 2002;133:456–462.

Auteurs

Panagiotis Laspas (P)

Department of Ophthalmology, University Medical Center, Johannes Gutenberg- University Mainz, Mainz.

Jochen Wahl (J)

Department of Ophthalmology, Helios Dr Horst Schmidt Kliniken Wiesbaden, Germany.

Henning Peters (H)

Department of Ophthalmology, University Medical Center, Johannes Gutenberg- University Mainz, Mainz.

Verena Prokosch-Willing (V)

Department of Ophthalmology, University Medical Center, Johannes Gutenberg- University Mainz, Mainz.

Panagiotis Chronopoulos (P)

Department of Ophthalmology, University Medical Center, Johannes Gutenberg- University Mainz, Mainz.

Franz Grehn (F)

Department of Ophthalmology, University Medical Center, Johannes Gutenberg- University Mainz, Mainz.

Norbert Pfeiffer (N)

Department of Ophthalmology, University Medical Center, Johannes Gutenberg- University Mainz, Mainz.

Esther M Hoffmann (EM)

Department of Ophthalmology, University Medical Center, Johannes Gutenberg- University Mainz, Mainz.

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