Identification of a Novel HIF-1α-α
Adult
Aged
CD11b Antigen
/ metabolism
CD18 Antigens
/ metabolism
Cells, Cultured
Extracellular Traps
/ metabolism
Female
Fibrosis
Humans
Hypoxia-Inducible Factor 1, alpha Subunit
/ metabolism
Lung
/ pathology
Lung Diseases, Interstitial
/ metabolism
Male
Middle Aged
Neutrophil Activation
Neutrophils
/ immunology
Signal Transduction
Transendothelial and Transepithelial Migration
HIF
NET
endothelium
hypoxia
integrin
interstitial lung disease
neutrophil
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2020
2020
Historique:
received:
05
06
2020
accepted:
11
08
2020
entrez:
12
11
2020
pubmed:
13
11
2020
medline:
27
5
2021
Statut:
epublish
Résumé
Neutrophilic inflammation correlates with mortality in fibrotic interstitial lung disease (ILD) particularly in the most severe form, idiopathic pulmonary fibrosis (IPF), although the underlying mechanisms remain unclear. Neutrophil function is modulated by numerous factors, including integrin activation, inflammatory cytokines and hypoxia. Hypoxia has an important role in inflammation and may also contribute to pulmonary disease. We aimed to determine how neutrophil activation occurs in ILD and the relative importance of hypoxia. Using lung biopsies and bronchoalveolar lavage (BAL) fluid from ILD patients we investigated the extent of hypoxia and neutrophil activation in ILD lungs. Then we used
Identifiants
pubmed: 33178179
doi: 10.3389/fimmu.2020.02190
pmc: PMC7594517
doi:
Substances chimiques
CD11b Antigen
0
CD18 Antigens
0
HIF1A protein, human
0
Hypoxia-Inducible Factor 1, alpha Subunit
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2190Subventions
Organisme : Versus Arthritis
ID : 21223
Pays : United Kingdom
Organisme : Department of Health
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/K004158/1
Pays : United Kingdom
Informations de copyright
Copyright © 2020 Khawaja, Chong, Sahota, Mikolasch, Pericleous, Ripoll, Booth, Khan, Rodriguez-Justo, Giles and Porter.
Références
Proc Natl Acad Sci U S A. 2004 Jul 13;101(28):10440-5
pubmed: 15235127
FASEB J. 2009 May;23(5):1338-46
pubmed: 19103643
Am J Physiol Lung Cell Mol Physiol. 2016 Feb 1;310(3):L249-62
pubmed: 26637636
N Engl J Med. 2020 Jul 9;383(2):120-128
pubmed: 32437596
PLoS One. 2014 Jun 06;9(6):e98259
pubmed: 24906014
Am J Respir Crit Care Med. 2016 Oct 15;194(8):948-960
pubmed: 27104832
J Leukoc Biol. 2020 Jan;107(1):69-83
pubmed: 31478251
Am Rev Respir Dis. 1987 Aug;136(2):288-92
pubmed: 3619187
J Exp Med. 1996 Sep 1;184(3):1003-15
pubmed: 9064318
J Clin Sleep Med. 2013 Jun 15;9(6):593-601
pubmed: 23772193
J Clin Invest. 1995 Jul;96(1):107-16
pubmed: 7615779
J Clin Invest. 1981 Jul;68(1):259-69
pubmed: 7251862
Proc Natl Acad Sci U S A. 1995 Jan 17;92(2):517-21
pubmed: 7831322
Br Med Bull. 2018 Dec 1;128(1):5-14
pubmed: 30137312
Eur Respir J. 2019 Sep 19;54(3):
pubmed: 31285305
Am J Respir Crit Care Med. 2014 Feb 1;189(3):314-24
pubmed: 24251580
Am J Respir Crit Care Med. 2012 Oct 15;186(8):740-51
pubmed: 22923663
Sci Rep. 2019 Feb 4;9(1):1283
pubmed: 30718722
Am J Respir Crit Care Med. 2017 Jul 15;196(2):132-138
pubmed: 28530124
Arthritis Rheumatol. 2015 Nov;67(11):2990-3003
pubmed: 26097119
Arthritis Rheum. 2005 Oct;52(10):3269-78
pubmed: 16206283
J Innate Immun. 2009;1(3):194-201
pubmed: 20375577
Thorax. 2016 Dec;71(12):1145-1153
pubmed: 27245780
N Engl J Med. 1986 May 22;314(21):1343-7
pubmed: 3702942
J Vis Exp. 2019 Sep 10;(151):
pubmed: 31566594
Sci Transl Med. 2016 Oct 19;8(361):361ra138
pubmed: 27798263
J Clin Med. 2016 Aug 18;5(8):
pubmed: 27548238
FASEB J. 2014 Oct;28(10):4223-34
pubmed: 24958208
Blood. 2012 Oct 11;120(15):3118-25
pubmed: 22919032
J Immunol. 2001 Aug 1;167(3):1601-8
pubmed: 11466382
Arterioscler Thromb Vasc Biol. 2016 Oct;36(10):2078-87
pubmed: 27470511
Am J Physiol Heart Circ Physiol. 2001 Jun;280(6):H2533-44
pubmed: 11356608
Am J Respir Cell Mol Biol. 2001 Dec;25(6):780-7
pubmed: 11726405
J Immunol. 2010 Mar 15;184(6):3284-97
pubmed: 20164424
J Exp Med. 2005 Jan 3;201(1):105-15
pubmed: 15630139
Crit Care Med. 2003 Apr;31(4 Suppl):S195-9
pubmed: 12682440
Am J Respir Crit Care Med. 2007 Dec 1;176(11):1108-19
pubmed: 17761615
Cell Death Discov. 2017 Apr 10;3:17010
pubmed: 28417017
Am J Physiol Lung Cell Mol Physiol. 2000 Dec;279(6):L1137-45
pubmed: 11076804
Am J Physiol Lung Cell Mol Physiol. 2018 Jul 1;315(1):L1-L10
pubmed: 29565179
Science. 2004 Mar 5;303(5663):1532-5
pubmed: 15001782
Am J Physiol Lung Cell Mol Physiol. 2016 Feb 15;310(4):L299-310
pubmed: 26702149
Chest. 1983 May;83(5 Suppl):59S
pubmed: 6301769
Chest. 2019 Oct;156(4):774-782
pubmed: 31265835
J Immunol. 2001 Dec 1;167(11):6140-9
pubmed: 11714773
J Exp Med. 2014 Jun 30;211(7):1485-97
pubmed: 24889201
Am J Respir Crit Care Med. 2012 Jan 1;185(1):67-76
pubmed: 22016448
Am J Physiol Lung Cell Mol Physiol. 2014 Aug 15;307(4):L283-94
pubmed: 24951777
Biosci Rep. 2016 May 20;36(3):
pubmed: 27129288
J Leukoc Biol. 1996 Feb;59(2):229-40
pubmed: 8603995
Cancer Res. 2005 Jun 1;65(11):4918-28
pubmed: 15930314
Nat Med. 2006 Sep;12(9):1056-64
pubmed: 16951685
Am J Respir Crit Care Med. 2012 May 1;185(9):1004-14
pubmed: 22550210
J Infect Dis. 2008 Jan 15;197(2):214-7
pubmed: 18173364
Am J Pathol. 2011 Sep;179(3):1455-70
pubmed: 21741942
Eur Respir Rev. 2014 Mar 1;23(131):40-54
pubmed: 24591661
J Immunol. 2005 Aug 1;175(3):1894-902
pubmed: 16034133
Am J Physiol. 1995 Oct;269(4 Pt 2):H1398-406
pubmed: 7485573
FASEB J. 1998 Feb;12(2):209-20
pubmed: 9472986
J Pathol. 2014 Jul;233(3):294-307
pubmed: 24740698
JCI Insight. 2020 Jun 4;5(11):
pubmed: 32329756
Front Immunol. 2019 Oct 01;10:2320
pubmed: 31632402
Antimicrob Agents Chemother. 2006 Feb;50(2):739-43
pubmed: 16436734
Cell Mol Gastroenterol Hepatol. 2017 Aug 16;5(1):15-30
pubmed: 29276749
BMC Pulm Med. 2017 Apr 26;17(1):72
pubmed: 28446163
J Cell Biol. 2007 Jan 15;176(2):231-41
pubmed: 17210947
Cell. 2012 Jul 6;150(1):165-78
pubmed: 22770218
Proteomics Clin Appl. 2014 Dec;8(11-12):932-50
pubmed: 25169739
FASEB J. 2016 Jun;30(6):2336-50
pubmed: 26956419
Cancer Res. 2005 Oct 1;65(19):9047-55
pubmed: 16204079
Clin Vaccine Immunol. 2012 Jul;19(7):1065-74
pubmed: 22552601
Nat Commun. 2018 Sep 14;9(1):3767
pubmed: 30218080
Cancer Res. 2002 Aug 1;62(15):4316-24
pubmed: 12154035
Front Immunol. 2016 Nov 25;7:518
pubmed: 27933059
Eur Respir J. 2000 May;15(5):895-901
pubmed: 10853855
FASEB J. 2016 Nov;30(11):3733-3744
pubmed: 27480571
Am J Pathol. 2007 Jan;170(1):65-74
pubmed: 17200183
J Exp Med. 2017 Feb;214(2):439-458
pubmed: 28031479
Sci Signal. 2011 Sep 6;4(189):ra57
pubmed: 21900205
Am J Physiol Lung Cell Mol Physiol. 2014 Feb;306(3):L217-30
pubmed: 24318116
Semin Immunopathol. 2013 Jul;35(4):455-63
pubmed: 23553215
J Exp Med. 2020 Jun 1;217(6):
pubmed: 32302401
Blood. 2014 Apr 17;123(16):2573-84
pubmed: 24335230
Am J Respir Crit Care Med. 2000 May;161(5):1698-704
pubmed: 10806177
Blood. 2014 Jan 16;123(3):366-76
pubmed: 24196071
Sci Rep. 2017 Jun 13;7(1):3409
pubmed: 28611461
Cell Death Differ. 2019 Mar;26(3):395-408
pubmed: 30622307