The role of the degenerate nucleotide binding site in type I ABC exporters.
ABC transporters
degenerate nucleotide binding site
transport cycle model
type I exporter
Journal
FEBS letters
ISSN: 1873-3468
Titre abrégé: FEBS Lett
Pays: England
ID NLM: 0155157
Informations de publication
Date de publication:
12 2020
12 2020
Historique:
received:
24
07
2020
revised:
26
09
2020
accepted:
15
10
2020
pubmed:
13
11
2020
medline:
5
6
2021
entrez:
12
11
2020
Statut:
ppublish
Résumé
ATP-binding cassette (ABC) transporters are fascinating molecular machines that are capable of transporting a large variety of chemically diverse compounds. The energy required for translocation is derived from binding and hydrolysis of ATP. All ABC transporters share a basic architecture and are composed of two transmembrane domains and two nucleotide binding domains (NBDs). The latter harbor all conserved sequence motifs that hallmark the ABC transporter superfamily. The NBDs form the nucleotide binding sites (NBSs) in their interface. Transporters with two active NBSs are called canonical transporters, while ABC exporters from eukaryotic organisms, including humans, frequently have a degenerate NBS1 containing noncanonical residues that strongly impair ATP hydrolysis. Here, we summarize current knowledge on degenerate ABC transporters. By integrating structural information with biophysical and biochemical evidence of asymmetric function, we develop a model for the transport cycle of degenerate ABC transporters. We will elaborate on the unclear functional advantages of a degenerate NBS.
Identifiants
pubmed: 33179257
doi: 10.1002/1873-3468.13997
pmc: PMC7756269
doi:
Substances chimiques
ATP-Binding Cassette Transporters
0
Adenosine Triphosphate
8L70Q75FXE
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
3815-3838Subventions
Organisme : Austrian Science Fund FWF
ID : W 1232
Pays : Austria
Informations de copyright
© 2020 The Authors. FEBS Letters published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies.
Références
Proc Natl Acad Sci U S A. 2013 Nov 19;110(47):18916-21
pubmed: 24191018
J Biol Chem. 1995 Aug 18;270(33):19383-90
pubmed: 7642618
Cell. 2017 Mar 23;169(1):85-95.e8
pubmed: 28340353
Biochim Biophys Acta. 2011 Dec;1808(12):2954-64
pubmed: 21840296
J Bacteriol. 1999 Apr;181(8):2659-62
pubmed: 10198038
Science. 2018 Feb 23;359(6378):915-919
pubmed: 29371429
Biochem Biophys Res Commun. 2017 Sep 30;491(4):986-993
pubmed: 28774558
J Biol Chem. 2003 Jul 18;278(29):26862-9
pubmed: 12746444
Cell. 2017 Jul 27;170(3):483-491.e8
pubmed: 28735752
Nat Struct Mol Biol. 2018 Apr;25(4):333-340
pubmed: 29610494
PLoS Comput Biol. 2010 Apr 29;6(4):e1000762
pubmed: 20454684
Sci Rep. 2019 Aug 15;9(1):11884
pubmed: 31417173
Nat Commun. 2012 Jun 26;3:925
pubmed: 22735453
Biophys J. 2018 Jan 23;114(2):331-342
pubmed: 29401431
Plant Cell. 2005 Nov;17(11):2922-39
pubmed: 16243904
Biochemistry. 2015 May 19;54(19):3086-99
pubmed: 25947941
Nat Commun. 2019 Jan 8;10(1):88
pubmed: 30622258
Biochemistry. 2008 Mar 25;47(12):3615-24
pubmed: 18303860
FEBS Lett. 1995 Dec 27;377(3):285-9
pubmed: 8549739
Nature. 2017 Nov 23;551(7681):525-528
pubmed: 29107940
Naunyn Schmiedebergs Arch Pharmacol. 2006 Mar;372(6):385-99
pubmed: 16541253
J Biol Chem. 2004 Nov 5;279(45):46518-26
pubmed: 15326176
Structure. 2001 Jul 3;9(7):571-86
pubmed: 11470432
Nature. 2005 Feb 24;433(7028):876-80
pubmed: 15729345
FEBS Lett. 2006 Feb 13;580(4):1049-55
pubmed: 16412422
J Biol Chem. 2000 Aug 11;275(32):25031-8
pubmed: 10831598
J Am Chem Soc. 2018 Apr 4;140(13):4527-4533
pubmed: 29308886
J Biol Chem. 1999 Apr 30;274(18):12209-12
pubmed: 10212185
EMBO J. 1982;1(8):945-51
pubmed: 6329717
J Biol Chem. 2000 Jul 7;275(27):20280-7
pubmed: 10781583
FEBS Lett. 2006 Feb 13;580(4):1036-41
pubmed: 16330029
Nature. 2016 May 04;533(7604):561-4
pubmed: 27144356
J Biol Chem. 2014 May 30;289(22):15272-9
pubmed: 24733388
Biochemistry. 2018 Oct 30;57(43):6234-6246
pubmed: 30281975
Protein Cell. 2018 Jun;9(6):553-567
pubmed: 29594720
Nature. 1998 Dec 17;396(6712):703-7
pubmed: 9872322
Pharmacol Res Perspect. 2020 Apr;8(2):e00572
pubmed: 32232949
Mol Pharmacol. 2017 Oct;92(4):401-413
pubmed: 28784620
J Biol Chem. 2004 Aug 13;279(33):34913-21
pubmed: 15192095
J Biol Chem. 2017 Jan 13;292(2):446-461
pubmed: 27864369
Mol Cell Biol. 1989 Dec;9(12):5289-97
pubmed: 2573836
J Biol Chem. 1994 Mar 25;269(12):8986-92
pubmed: 7907596
J Biol Chem. 1996 Mar 1;271(9):4858-63
pubmed: 8617756
FEBS Lett. 2006 Feb 13;580(4):1103-11
pubmed: 16387301
Nature. 2006 Sep 14;443(7108):180-5
pubmed: 16943773
Biochim Biophys Acta. 2011 Jul;1808(7):1790-6
pubmed: 21315686
Mol Pharmacol. 2000 Sep;58(3):624-32
pubmed: 10953057
Cell. 2017 Mar 9;168(6):1075-1085.e9
pubmed: 28238471
J Biol Chem. 2007 Aug 3;282(31):22793-803
pubmed: 17485460
Mol Cell. 2006 Oct 6;24(1):51-62
pubmed: 17018292
Cell. 2000 Jun 23;101(7):789-800
pubmed: 10892749
J Biol Chem. 2003 Oct 3;278(40):38537-47
pubmed: 12882957
Annu Rev Pharmacol Toxicol. 2014;54:95-117
pubmed: 24050699
J Biol Chem. 2002 Feb 15;277(7):5110-9
pubmed: 11741902
Biochim Biophys Acta. 2005 Mar 1;1668(2):248-61
pubmed: 15737336
Proteins. 2009 May 1;75(2):387-96
pubmed: 18831048
Elife. 2020 Apr 21;9:
pubmed: 32314962
Cell. 2018 Jan 11;172(1-2):81-89.e10
pubmed: 29290467
Biophys J. 2018 Apr 24;114(8):1751-1754
pubmed: 29694855
Mol Cell. 2002 Jul;10(1):139-49
pubmed: 12150914
Cell Res. 2020 Jul;30(7):623-625
pubmed: 32203132
Biochemistry. 2000 Nov 21;39(46):14138-49
pubmed: 11087362
Mol Cell. 2003 Sep;12(3):651-61
pubmed: 14527411
J Biol Chem. 1996 Jan 26;271(4):1877-83
pubmed: 8567633
Elife. 2019 Jul 25;8:
pubmed: 31343405
Nature. 2017 Mar 30;543(7647):738-741
pubmed: 28289287
Proc Natl Acad Sci U S A. 2014 Jun 24;111(25):9145-50
pubmed: 24920594
J Gen Physiol. 2010 May;135(5):399-414
pubmed: 20421370
Cell Res. 2019 Dec;29(12):1039-1041
pubmed: 31467407
Cell Rep. 2019 May 7;27(6):1848-1857.e4
pubmed: 31067468
PLoS Genet. 2020 Oct 8;16(10):e1009016
pubmed: 33031417
Trends Pharmacol Sci. 2006 Aug;27(8):438-46
pubmed: 16820223
Cell. 2016 Dec 1;167(6):1586-1597.e9
pubmed: 27912062
Elife. 2016 Jun 21;5:
pubmed: 27328319
Biophys J. 2011 Jun 22;100(12):3025-34
pubmed: 21689537
Physiol Rev. 2019 Jan 1;99(1):707-738
pubmed: 30516439
IUCrJ. 2020 Jun 06;7(Pt 4):663-672
pubmed: 32695413
Biochim Biophys Acta. 2007 Feb;1768(2):324-35
pubmed: 17187755
Biochem J. 2008 Nov 15;416(1):129-36
pubmed: 18605986
J Phys Chem A. 2012 Mar 22;116(11):3004-13
pubmed: 22369471
J Biol Chem. 1997 Aug 29;272(35):21883-91
pubmed: 9268321
J Biol Chem. 2004 Jul 23;279(30):31212-20
pubmed: 15159388
Proc Natl Acad Sci U S A. 2008 Apr 1;105(13):5069-74
pubmed: 18356296
Nature. 1986 Oct 2-8;323(6087):448-50
pubmed: 3762694
Proc Natl Acad Sci U S A. 1999 Feb 16;96(4):1268-72
pubmed: 9990013
Biochem J. 2015 May 1;467(3):353-63
pubmed: 25886173
Sci Rep. 2015 Jan 20;5:7880
pubmed: 25600711
J Gen Physiol. 2003 Sep;122(3):333-48
pubmed: 12939393
Can J Genet Cytol. 1975 Dec;17(4):503-15
pubmed: 1203765
Proc Natl Acad Sci U S A. 2014 Jul 29;111(30):11025-30
pubmed: 25030449
Cell Mol Life Sci. 2020 Feb;77(4):765-778
pubmed: 31327045
Nature. 2015 Jan 15;517(7534):396-400
pubmed: 25363761
J Biol Chem. 2004 Dec 31;279(53):55283-9
pubmed: 15504721
Annu Rev Cell Biol. 1992;8:67-113
pubmed: 1282354
EMBO J. 2005 Jun 1;24(11):1901-10
pubmed: 15889153
J Biol Chem. 1999 Sep 17;274(38):26727-35
pubmed: 10480876
FEBS J. 2010 Oct;277(19):3974-85
pubmed: 20731718
Elife. 2020 May 27;9:
pubmed: 32458799
Nature. 2012 Oct 25;490(7421):566-9
pubmed: 23000902
Nat Commun. 2015 Sep 03;6:8113
pubmed: 26334616
Nat Struct Mol Biol. 2004 Oct;11(10):918-26
pubmed: 15452563
J Biol Chem. 2000 Jun 9;275(23):17626-30
pubmed: 10747957
Exp Eye Res. 2009 Nov;89(5):602-3
pubmed: 19306869
Biochem J. 2005 Mar 15;386(Pt 3):489-95
pubmed: 15636583
J Biol Chem. 2003 Feb 7;278(6):3599-605
pubmed: 12458196
Proc Natl Acad Sci U S A. 2017 Jan 24;114(4):E438-E447
pubmed: 28069938
Biochemistry. 2001 Dec 25;40(51):15733-42
pubmed: 11747450
Proteins. 2011 Jun;79(6):1977-90
pubmed: 21488101
Science. 2019 Jun 21;364(6446):1184-1188
pubmed: 31221859
J Biol Chem. 1998 Sep 11;273(37):23844-8
pubmed: 9726996
J Biol Chem. 2003 Nov 21;278(47):47002-8
pubmed: 12968023
J Am Chem Soc. 2020 Jul 22;142(29):12791-12801
pubmed: 32578427
Nature. 1966 Aug 27;211(5052):969-70
pubmed: 5968307
Proc Natl Acad Sci U S A. 2018 Dec 11;115(50):12757-12762
pubmed: 30459277
J Biol Chem. 2012 Jun 8;287(24):20395-406
pubmed: 22523072
J Gen Physiol. 2013 Jul;142(1):61-73
pubmed: 23752332
Biochim Biophys Acta. 1976 Nov 11;455(1):152-62
pubmed: 990323
J Biol Chem. 1998 Jul 3;273(27):16631-4
pubmed: 9642211
J Bacteriol. 2018 Mar 26;200(8):
pubmed: 29437852
Nature. 2015 Aug 27;524(7566):433-8
pubmed: 26266984
Mol Pharmacol. 2011 Mar;79(3):443-52
pubmed: 21177413
EMBO J. 2001 Oct 15;20(20):5615-25
pubmed: 11598005
Sci Rep. 2020 Feb 13;10(1):2589
pubmed: 32054924
J Biol Chem. 1995 Nov 10;270(45):26956-61
pubmed: 7592942
Biophys J. 2011 Jul 6;101(1):110-7
pubmed: 21723820
J Biol Chem. 2011 Mar 4;286(9):7308-14
pubmed: 21209088
BMC Struct Biol. 2018 Dec 13;18(1):17
pubmed: 30545335
Nat Cell Biol. 2008 Oct;10(10):1217-23
pubmed: 18776898
Curr Biol. 2001 Feb 20;11(4):242-51
pubmed: 11250152
Curr Opin Struct Biol. 2002 Dec;12(6):754-60
pubmed: 12504680
J Biol Chem. 2002 Jun 14;277(24):21111-4
pubmed: 11964392
Nature. 2019 Jul;571(7766):580-583
pubmed: 31316210
J Biol Chem. 2001 Mar 9;276(10):7526-33
pubmed: 11099504
Biochemistry. 2007 Dec 4;46(48):13787-99
pubmed: 17988154
Mol Pharmacol. 2014 Mar;85(3):420-8
pubmed: 24366667
Sci Adv. 2017 Aug 09;3(8):e1701440
pubmed: 28808685
Mol Microbiol. 2007 Jul;65(2):250-7
pubmed: 17578454
Elife. 2017 Dec 29;6:
pubmed: 29286281
Proc Natl Acad Sci U S A. 2001 Jun 19;98(13):7431-6
pubmed: 11381133
Protein Eng Des Sel. 2010 May;23(5):375-84
pubmed: 20150177
FASEB J. 2009 May;23(5):1287-302
pubmed: 19174475
J Biol Chem. 2000 Apr 28;275(17):13098-108
pubmed: 10777615
Elife. 2016 Dec 09;5:
pubmed: 27935481
Science. 2019 Feb 15;363(6428):753-756
pubmed: 30765569
Nat Struct Mol Biol. 2012 Mar 25;19(4):395-402
pubmed: 22447242
Philos Trans R Soc Lond B Biol Sci. 2009 Jan 27;364(1514):239-45
pubmed: 18957379
Elife. 2017 Oct 24;6:
pubmed: 29035201
Protein Sci. 2014 Jan;23(1):34-46
pubmed: 24155053
Biochemistry. 2008 May 27;47(21):5699-708
pubmed: 18452308
Science. 2002 May 10;296(5570):1091-8
pubmed: 12004122
Sci Rep. 2019 May 23;9(1):7761
pubmed: 31123301
J Biol Chem. 2013 Jun 28;288(26):19211-20
pubmed: 23658020
Nat Commun. 2014 Nov 07;5:5419
pubmed: 25377891
Proc Natl Acad Sci U S A. 2010 Feb 2;107(5):2355-60
pubmed: 20133880
Elife. 2017 Jan 04;6:
pubmed: 28051765
J Am Chem Soc. 2018 Apr 4;140(13):4543-4551
pubmed: 29547697
Nat Commun. 2019 May 21;10(1):2260
pubmed: 31113958
Proc Natl Acad Sci U S A. 2014 Mar 18;111(11):4049-54
pubmed: 24591620
J Biol Chem. 2006 Sep 15;281(37):27471-80
pubmed: 16864587
Chem Rev. 2015 Feb 25;115(4):1702-24
pubmed: 25607981