Atypical parkinsonian syndromes in a North African tertiary referral center.
Parkinson's disease
atypical parkinsonism
epidemiology
Journal
Brain and behavior
ISSN: 2162-3279
Titre abrégé: Brain Behav
Pays: United States
ID NLM: 101570837
Informations de publication
Date de publication:
01 2021
01 2021
Historique:
received:
17
04
2020
revised:
06
09
2020
accepted:
14
10
2020
pubmed:
13
11
2020
medline:
1
7
2021
entrez:
12
11
2020
Statut:
ppublish
Résumé
Data on epidemiology of atypical parkinsonian syndromes (APS) in North African countries are limited. Our objective was to study the epidemiological features of APS in a Tunisian population. We conducted a 17-year retrospective cross-sectional descriptive study in the Department of Neurology at Razi University Hospital. We included all patients responding to consensus diagnosis criteria of APS. We recorded demographic and clinical data. Group differences were assessed with a post hoc ANOVA with a Bonferroni error correction. We included 464 APS patients. Hospital prevalence of APS among all parkinsonism cases was 20.6%. Mean annual increase of incidence defined as newly diagnosed APS cases per year reached 38.8%/year. APS were divided into 4 etiological subgroups: dementia with Lewy bodies (DLB; 56.7%); progressive supranuclear palsy(PSP; 16.2%); multiple system atrophy (MSA; 14.6%); and finally corticobasal syndrome (CBS; 12.5%). Sex-ratio was 1.2. This male predominance was found in all subgroups except MSA (p = .013). Mean age at onset was 68.5 years, most belated in DLB (69.7 years; p < .001). Young-onset parkinsonism (<40 years) was found only in MSA subgroup (p = .031). Parkinsonism was of late onset (>70 years) in 50.7% of patients and was significantly associated with DLB subgroup (p = .013). Inaugural parkinsonism was associated with CBS and MSA (p = .0497), and gait disorders at disease onset were associated with PSP and MSA (p = .0062). Cognitive and mood disorders were more marked in DLB and most preserved in MSA. Consanguinity was more marked in CBS (p = .037), and family history of dementia and psychiatric diseases was more common in DLB. Thirty-seven families with similar cases of APS were identified. This is the largest African epidemiological study on APS. In our population, APS were frequent and dominated by DLB. The age of onset of parkinsonism was the most decisive feature for differential diagnosis.
Identifiants
pubmed: 33179436
doi: 10.1002/brb3.1924
pmc: PMC7821582
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e01924Informations de copyright
© 2020 The Authors. Brain and Behavior published by Wiley Periodicals LLC.
Références
Neurology. 2013 Aug 27;81(9):833-40
pubmed: 23892702
Front Neurol. 2019 Jan 22;10:5
pubmed: 30723450
Parkinsonism Relat Disord. 2019 Nov;68:79-84
pubmed: 31621626
Brain Behav. 2021 Jan;11(1):e01924
pubmed: 33179436
Eur J Neurol. 2018 Jan;25(1):41-58
pubmed: 28803444
Int Psychogeriatr. 2002 Jun;14(2):211-8
pubmed: 12243211
Int Rev Neurobiol. 2019;149:1-34
pubmed: 31779810
Curr Opin Neurol. 2016 Aug;29(4):480-5
pubmed: 27272977
Neurol Sci. 2015 Jul;36(7):1303-5
pubmed: 25515788
Neurosciences (Riyadh). 2012 Jan;17(1):66-8
pubmed: 22246015
Neurology. 2017 Jul 4;89(1):88-100
pubmed: 28592453
Mov Disord. 2017 Jun;32(6):853-864
pubmed: 28467028
Dakar Med. 1988;33(1-4):30-5
pubmed: 3079273
Neuropsychiatr Dis Treat. 2018 Oct 09;14:2643-2656
pubmed: 30349262
Rev Neurol (Paris). 2013 Feb;169(2):121-5
pubmed: 22763206
Rev Neurol (Paris). 2016 Nov;172(11):709-714
pubmed: 27344208
BMC Neurol. 2010 Jan 05;10:1
pubmed: 20051133
Brain Pathol. 2013 Jan;23(1):28-33
pubmed: 22702335
Parkinsonism Relat Disord. 2019 Feb;59:82-92
pubmed: 30409560
Neurology. 2008 Aug 26;71(9):670-6
pubmed: 18725592
Ageing Int. 2017;42(3):274-289
pubmed: 28890585
Int J Mol Sci. 2015 Oct 16;16(10):24629-55
pubmed: 26501269
Neurology. 2013 Jan 29;80(5):496-503
pubmed: 23359374
J Neurol. 2018 Feb;265(2):439-445
pubmed: 29063240
BMC Public Health. 2014 Jun 26;14:653
pubmed: 24969686
Neurol Sci. 2015 Sep;36(9):1651-7
pubmed: 25917399
Lancet. 2000 Feb 5;355(9202):495-6
pubmed: 10841152
Afr J Psychiatry (Johannesbg). 2011 Nov;14(5):377-82
pubmed: 22183468
Neurology. 2007 Jan 30;68(5):384-6
pubmed: 17082464
Acta Neurol Scand. 2018 Nov;138(5):425-431
pubmed: 29989150
Int Rev Neurobiol. 2019;149:327-351
pubmed: 31779819
West Afr J Med. 1993 Jul-Sep;12(3):175-6
pubmed: 8312218
JAMA Neurol. 2013 Jul;70(7):859-66
pubmed: 23689920
Neurol Clin. 2001 Aug;19(3):607-27, vi
pubmed: 11532646
Neurology. 2014 Sep 2;83(10):948
pubmed: 25179998
Mov Disord. 2013 Aug;28(9):1184-99
pubmed: 23720239
Neuroepidemiology. 1988;7(3):159-64
pubmed: 3405368
Ann Afr Med. 2013 Jan-Mar;12(1):46-8
pubmed: 23480996
JAMA Neurol. 2020 Mar 1;77(3):377-387
pubmed: 31860007