Biophysical and morphological changes in inner hair cells and their efferent innervation in the ageing mouse cochlea.
C3H/HeJ mice
C57BL/6 mice
auditory brainstem responses
cadherin 23
cochlea
hair cells
hearing loss
mechanoelectrical transduction
olivocochlear efferent fibres
potassium currents
Journal
The Journal of physiology
ISSN: 1469-7793
Titre abrégé: J Physiol
Pays: England
ID NLM: 0266262
Informations de publication
Date de publication:
01 2021
01 2021
Historique:
received:
28
05
2020
accepted:
01
10
2020
pubmed:
13
11
2020
medline:
13
4
2021
entrez:
12
11
2020
Statut:
ppublish
Résumé
Age-related hearing loss is a progressive hearing loss involving environmental and genetic factors, leading to a decrease in hearing sensitivity, threshold and speech discrimination. We compared age-related changes in inner hair cells (IHCs) between four mouse strains with different levels of progressive hearing loss. The surface area of apical coil IHCs (9-12 kHz cochlear region) decreases by about 30-40% with age. The number of BK channels progressively decreases with age in the IHCs from most mouse strains, but the basolateral membrane current profile remains unchanged. The mechanoelectrical transducer current is smaller in mice harbouring the hypomorphic Cdh23 allele Cdh23 Inner hair cells (IHCs) are the primary sensory receptors of the mammalian cochlea, transducing acoustic information into electrical signals that are relayed to the afferent neurons. Functional changes in IHCs are a potential cause of age-related hearing loss. Here, we have investigated the functional characteristics of IHCs from early-onset hearing loss mice harbouring the allele Cdh23
Identifiants
pubmed: 33179774
doi: 10.1113/JP280256
pmc: PMC7612127
mid: EMS140586
doi:
Substances chimiques
Cadherins
0
Cdh23 protein, mouse
0
Large-Conductance Calcium-Activated Potassium Channels
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
269-287Subventions
Organisme : Wellcome Trust
ID : 102892
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UP_1503/2
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 102892/Z/13/Z
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/T004991/1
Pays : United Kingdom
Informations de copyright
© 2020 The Authors. The Journal of Physiology published by John Wiley & Sons Ltd on behalf of The Physiological Society.
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