NT-proBNP and metabolic risk factors in a bi-ethnic cohort: the Ambulatory Blood Pressure in African prospective cohort study.
Adult
Biomarkers
/ blood
Black People
Blood Pressure
Blood Pressure Monitoring, Ambulatory
Cardiometabolic Risk Factors
Cross-Sectional Studies
Female
Humans
Incidence
Male
Metabolic Syndrome
/ blood
Middle Aged
Natriuretic Peptide, Brain
/ blood
Peptide Fragments
/ blood
Prevalence
Prospective Studies
Race Factors
Risk Assessment
South Africa
/ epidemiology
White People
Young Adult
Africans
Caucasians
NT‐proBNP
bi‐ethnic
metabolic
Journal
Cardiovascular journal of Africa
ISSN: 1680-0745
Titre abrégé: Cardiovasc J Afr
Pays: South Africa
ID NLM: 101313864
Informations de publication
Date de publication:
Historique:
received:
21
01
2019
accepted:
16
06
2020
pubmed:
13
11
2020
medline:
14
7
2021
entrez:
12
11
2020
Statut:
ppublish
Résumé
We explored the association of N-terminal probrain natriuretic peptide (NT-proBNP) with metabolic traits in a bi-ethnic African-Caucasian cohort. Baseline examinations of the Sympathetic activity and Ambulatory Blood Pressure in African (SABPA) prospective cohort study were performed between 2008 and 2009, and re-examination after a three-year follow up in South African teachers (black African, Each one standard deviation increment of NT-proBNP was significantly inversely associated with body mass index ( β -1.01), glycated haemoglobin ( β -0.14 %), waist circumference (β -1.82), HOMA-IR (β -0.47), insulin (β -1.66) and triglyceride levels (β -0.04). Each one standard deviation increment of NT-proBNP was also associated with reduced odds of incident diabetes, and subjects within the highest quartile of NT-proBNP were at lowest risk (OR: 0.24; 95% CI: 0.06-0.96; In the SABPA cohort, Africans and Caucasians had similar NT-proBNP levels; however, the associations for Africans were stronger. Those findings suggest that BNP may affect the propensity for metabolic disturbances differently in Africans and Caucasians.
Sections du résumé
BACKGROUND
We explored the association of N-terminal probrain natriuretic peptide (NT-proBNP) with metabolic traits in a bi-ethnic African-Caucasian cohort.
METHODS
Baseline examinations of the Sympathetic activity and Ambulatory Blood Pressure in African (SABPA) prospective cohort study were performed between 2008 and 2009, and re-examination after a three-year follow up in South African teachers (black African,
RESULTS
Each one standard deviation increment of NT-proBNP was significantly inversely associated with body mass index ( β -1.01), glycated haemoglobin ( β -0.14 %), waist circumference (β -1.82), HOMA-IR (β -0.47), insulin (β -1.66) and triglyceride levels (β -0.04). Each one standard deviation increment of NT-proBNP was also associated with reduced odds of incident diabetes, and subjects within the highest quartile of NT-proBNP were at lowest risk (OR: 0.24; 95% CI: 0.06-0.96;
CONCLUSIONS
In the SABPA cohort, Africans and Caucasians had similar NT-proBNP levels; however, the associations for Africans were stronger. Those findings suggest that BNP may affect the propensity for metabolic disturbances differently in Africans and Caucasians.
Identifiants
pubmed: 33180090
doi: 10.5830/CVJA-2020-017
doi:
Substances chimiques
Biomarkers
0
Peptide Fragments
0
pro-brain natriuretic peptide (1-76)
0
Natriuretic Peptide, Brain
114471-18-0
Types de publication
Comparative Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM