Piezo1 Inactivation in Chondrocytes Impairs Trabecular Bone Formation.
CHONDROCYTE
ENDOCHONDRAL OSSIFICATION
MECHANOSENSATION
OSTEOBLAST
PIEZO1
Journal
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
ISSN: 1523-4681
Titre abrégé: J Bone Miner Res
Pays: United States
ID NLM: 8610640
Informations de publication
Date de publication:
02 2021
02 2021
Historique:
received:
08
05
2020
revised:
21
09
2020
accepted:
11
10
2020
pubmed:
13
11
2020
medline:
10
8
2021
entrez:
12
11
2020
Statut:
ppublish
Résumé
The skeleton is a dynamic tissue continuously adapting to mechanical stimuli. Although matrix-embedded osteocytes are considered as the key mechanoresponsive bone cells, all other skeletal cell types are principally exposed to macroenvironmental and microenvironmental mechanical influences that could potentially affect their activities. It was recently reported that Piezo1, one of the two mechanically activated ion channels of the Piezo family, functions as a mechanosensor in osteoblasts and osteocytes. Here we show that Piezo1 additionally plays a critical role in the process of endochondral bone formation. More specifically, by targeted deletion of Piezo1 or Piezo2 in either osteoblast (Runx2Cre) or osteoclast lineage cells (Lyz2Cre), we observed severe osteoporosis with numerous spontaneous fractures specifically in Piezo1
Substances chimiques
Ion Channels
0
Piezo1 protein, mouse
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
369-384Subventions
Organisme : Wellcome Trust
ID : 110044/Z/15/Z
Pays : United Kingdom
Informations de copyright
© 2020 The Authors. Journal of Bone and Mineral Research published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research (ASBMR).
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