Galectin-1 Expression in CD8
Journal
The Journal of investigative dermatology
ISSN: 1523-1747
Titre abrégé: J Invest Dermatol
Pays: United States
ID NLM: 0426720
Informations de publication
Date de publication:
06 2021
06 2021
Historique:
received:
26
03
2020
revised:
05
10
2020
accepted:
14
10
2020
pubmed:
13
11
2020
medline:
20
11
2021
entrez:
12
11
2020
Statut:
ppublish
Résumé
Allergic contact dermatitis, also known as contact hypersensitivity, is a frequent T-cell‒mediated inflammatory skin disease characterized by red, itchy, swollen, and cracked skin. It is caused by the direct contact with an allergen and/or irritant hapten. Galectin-1 (Gal-1) is a β-galactoside‒binding lectin, which is highly expressed in several types of immune cells. The role of endogenous Gal-1 in contact hypersensitivity is not known. We found that Gal-1‒deficient mice display more sustained and prolonged skin inflammation than wild-type mice after oxazolone treatment. Gal-1‒deficient mice have increased CD8
Identifiants
pubmed: 33181141
pii: S0022-202X(20)32281-8
doi: 10.1016/j.jid.2020.10.020
pii:
doi:
Substances chimiques
Galectin 1
0
Lgals1 protein, mouse
0
Oxazolone
15646-46-5
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1522-1532.e3Informations de copyright
Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.