Crystal structure of a guanine nucleotide exchange factor encoded by the scrub typhus pathogen
Bacterial Proteins
/ chemistry
Binding Sites
Crystallography, X-Ray
Guanine Nucleotide Exchange Factors
/ chemistry
Models, Molecular
Multiprotein Complexes
Orientia tsutsugamushi
/ metabolism
Protein Binding
Protein Conformation
Protein Interaction Domains and Motifs
Scrub Typhus
/ microbiology
rac1 GTP-Binding Protein
/ chemistry
rho GTP-Binding Proteins
/ chemistry
Orientia tsutsugamushi
Rac1
X-ray crystallography
guanine nucleotide exchange factor
scrub typhus
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
01 12 2020
01 12 2020
Historique:
pubmed:
14
11
2020
medline:
26
1
2021
entrez:
13
11
2020
Statut:
ppublish
Résumé
Rho family GTPases regulate an array of cellular processes and are often modulated by pathogens to promote infection. Here, we identify a cryptic guanine nucleotide exchange factor (GEF) domain in the OtDUB protein encoded by the pathogenic bacterium
Identifiants
pubmed: 33184172
pii: 2018163117
doi: 10.1073/pnas.2018163117
pmc: PMC7720168
doi:
Substances chimiques
Bacterial Proteins
0
Guanine Nucleotide Exchange Factors
0
Multiprotein Complexes
0
rac1 GTP-Binding Protein
EC 3.6.5.2
rho GTP-Binding Proteins
EC 3.6.5.2
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
30380-30390Subventions
Organisme : NINDS NIH HHS
ID : R21 NS112121
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH115939
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM136325
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI116313
Pays : United States
Organisme : NINDS NIH HHS
ID : F31 NS113511
Pays : United States
Organisme : NIGMS NIH HHS
ID : P30 GM124165
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS105640
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM046904
Pays : United States
Déclaration de conflit d'intérêts
The authors declare no competing interest.
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