A Rapid Mercury Droplet Electrode Polarography Method for Determination of Blood Lead Level in Lead Poisoned People.
Journal
Drug research
ISSN: 2194-9387
Titre abrégé: Drug Res (Stuttg)
Pays: Germany
ID NLM: 101602406
Informations de publication
Date de publication:
Apr 2021
Apr 2021
Historique:
pubmed:
14
11
2020
medline:
9
11
2021
entrez:
13
11
2020
Statut:
ppublish
Résumé
Lead is a hazardous heavy metal, which causes many problems in the human body. Unfortunately, recent reports showed that smugglers and opium sellers add lead to drugs during the production procedure in order to increase its weight and cost. The aim of this study was development of a rapid and accurate method for measurement of blood lead levels (BLL) in the oral and inhaled opiate abuser people. BLL in samples obtained from the oral and inhaled opium addicted patients referring to Sina Hospital in Tabriz, Iran, during 2017 was compared with healthy control group (N=15). The wet digestion method was used to prepare whole blood and Mercury Droplet Electrode Polarography (MDEP) method was utilized for measurement of the lead content of digested samples. Results showed that there were significant differences between the BLL of samples obtained from oral (17.12±74.61 μg/dL, p<0.0003) and inhaled (19.33±2.257 μg/dL, p<0.0001) opium addicted groups in comparison with healthy control group (4.669±0.3367 μg/dL). Based on the results of this study it was observed that BLL in opium addicted people needs to be measured as soon as possible. Furthermore, screening of blood lead concentrations in opium-addicted people with a rapid and accurate MDEP method is very necessary and important.
Sections du résumé
BACKGROUND
BACKGROUND
Lead is a hazardous heavy metal, which causes many problems in the human body. Unfortunately, recent reports showed that smugglers and opium sellers add lead to drugs during the production procedure in order to increase its weight and cost.
PURPOSE
OBJECTIVE
The aim of this study was development of a rapid and accurate method for measurement of blood lead levels (BLL) in the oral and inhaled opiate abuser people.
METHODS
METHODS
BLL in samples obtained from the oral and inhaled opium addicted patients referring to Sina Hospital in Tabriz, Iran, during 2017 was compared with healthy control group (N=15). The wet digestion method was used to prepare whole blood and Mercury Droplet Electrode Polarography (MDEP) method was utilized for measurement of the lead content of digested samples.
RESULTS
RESULTS
Results showed that there were significant differences between the BLL of samples obtained from oral (17.12±74.61 μg/dL, p<0.0003) and inhaled (19.33±2.257 μg/dL, p<0.0001) opium addicted groups in comparison with healthy control group (4.669±0.3367 μg/dL).
CONCLUSION
CONCLUSIONS
Based on the results of this study it was observed that BLL in opium addicted people needs to be measured as soon as possible. Furthermore, screening of blood lead concentrations in opium-addicted people with a rapid and accurate MDEP method is very necessary and important.
Substances chimiques
Lead
2P299V784P
Opium
8008-60-4
Mercury
FXS1BY2PGL
Types de publication
Journal Article
Observational Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
193-198Informations de copyright
Thieme. All rights reserved.
Déclaration de conflit d'intérêts
The authors have no conflict of interest to declare.