Centrosomes in disease: how the same music can sound so different?
Journal
Current opinion in structural biology
ISSN: 1879-033X
Titre abrégé: Curr Opin Struct Biol
Pays: England
ID NLM: 9107784
Informations de publication
Date de publication:
02 2021
02 2021
Historique:
received:
17
08
2020
revised:
22
09
2020
accepted:
23
09
2020
pubmed:
14
11
2020
medline:
16
10
2021
entrez:
13
11
2020
Statut:
ppublish
Résumé
Centrosomes are the major microtubule organizing center of animal cells. Centrosomes contribute to timely bipolar spindle assembly during mitosis and participate in the regulation of other processes such as polarity establishment and cell migration. Centrosome numbers are tightly controlled during the cell cycle to ensure that mitosis is initiated with only two centrosomes. Deviations in centrosome number or structure are known to impact cell or tissue homeostasis and can impact different processes as diverse as proliferation, death or disease. Interestingly, defects in centrosome number seem to culminate with common responses, which depend on p53 activation even in different contexts such as development or cancer. p53 is a tumor suppressor gene with essential roles in the maintenance of genetic stability normally stimulated by various cellular stresses. Here, we review current knowledge and discuss how defects in centrosome structure and number can lead to different human pathologies.
Identifiants
pubmed: 33186811
pii: S0959-440X(20)30163-9
doi: 10.1016/j.sbi.2020.09.011
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
74-82Informations de copyright
Copyright © 2020. Published by Elsevier Ltd.