Pivotal Role of Fatty Acid Synthase in c-MYC Driven Hepatocarcinogenesis.
Animals
Apoptosis
/ genetics
Carcinogenesis
/ genetics
Carcinoma, Hepatocellular
/ genetics
Cell Line, Tumor
Cell Proliferation
/ genetics
Fatty Acid Synthase, Type I
/ genetics
Genes, myc
/ genetics
Humans
Lipogenesis
/ genetics
Liver Neoplasms
/ genetics
Mechanistic Target of Rapamycin Complex 1
/ metabolism
Mice
Mice, Inbred C57BL
Mice, Knockout
Myeloid Cell Leukemia Sequence 1 Protein
/ metabolism
Proto-Oncogene Proteins c-myc
/ genetics
RNA, Messenger
/ genetics
Transcription, Genetic
/ genetics
Up-Regulation
/ genetics
FASN
c-Myc
hepatocellular carcinoma
lipogenesis
mouse models
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
11 Nov 2020
11 Nov 2020
Historique:
received:
29
06
2020
revised:
08
11
2020
accepted:
08
11
2020
entrez:
14
11
2020
pubmed:
15
11
2020
medline:
4
3
2021
Statut:
epublish
Résumé
Hepatocellular carcinoma (HCC) is a deadly form of liver malignancy with limited treatment options. Amplification and/or overexpression of
Identifiants
pubmed: 33187130
pii: ijms21228467
doi: 10.3390/ijms21228467
pmc: PMC7696085
pii:
doi:
Substances chimiques
MYC protein, human
0
Myeloid Cell Leukemia Sequence 1 Protein
0
Proto-Oncogene Proteins c-myc
0
RNA, Messenger
0
FASN protein, human
EC 2.3.1.85
Fatty Acid Synthase, Type I
EC 2.3.1.85
Mechanistic Target of Rapamycin Complex 1
EC 2.7.11.1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIDDK NIH HHS
ID : P30 DK026743
Pays : United States
Organisme : Foundation for the National Institutes of Health
ID : R01CA221916
Organisme : Liver Center, University of California, San Francisco
ID : P30DK026743
Organisme : Associazione Italiana per la Ricerca sul Cancro
ID : IG19175
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