Torque Teno Virus Viral Load as a Marker of Immune Function in Allogeneic Haematopoietic Stem Cell Transplantation Recipients.
Adult
Biomarkers
/ blood
Cell Proliferation
DNA Virus Infections
/ blood
Female
Hematopoietic Stem Cell Transplantation
Humans
Immunosuppression Therapy
Leukocytes, Mononuclear
/ metabolism
Lymphocyte Count
Male
Middle Aged
Prospective Studies
Torque teno virus
/ growth & development
Viral Load
Viremia
/ blood
allogeneic haematopoietic stem cell transplantation (allo-HSCT)
biomarker
immune functional assay
immunocompetence
torque teno virus (TTV)
Journal
Viruses
ISSN: 1999-4915
Titre abrégé: Viruses
Pays: Switzerland
ID NLM: 101509722
Informations de publication
Date de publication:
11 11 2020
11 11 2020
Historique:
received:
12
10
2020
revised:
05
11
2020
accepted:
09
11
2020
entrez:
14
11
2020
pubmed:
15
11
2020
medline:
2
3
2021
Statut:
epublish
Résumé
Torque teno virus (TTV) has been proposed as a surrogate biomarker of T-cell function in allogeneic-haematopoietic-stem-cell transplantation (allo-HSCT). Conflicting data exists regarding the value of TTV to assess the degree of immunosuppression. The aim of the present study was to investigate the correlation between TTV viral load and immune function. Using samples from a prospective cohort composed of healthy-volunteers (HV) and allo-HSCT recipients at 6 months post-transplantation, we assessed the correlation between TTV viraemia and immune cell counts or T-cell proliferation capacity post-phytohaemagglutinin stimulation. TTV viraemia was detected in 68% of HV (
Identifiants
pubmed: 33187285
pii: v12111292
doi: 10.3390/v12111292
pmc: PMC7696489
pii:
doi:
Substances chimiques
Biomarkers
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Références
Med Microbiol Immunol. 2019 Apr;208(2):253-258
pubmed: 30852649
J Gen Virol. 2015 Jan;96(Pt 1):115-117
pubmed: 25304651
Biol Blood Marrow Transplant. 2018 Jan;24(1):194-199
pubmed: 29032273
Biol Blood Marrow Transplant. 2018 Jul;24(7):1341-1349
pubmed: 29530767
Front Immunol. 2016 Nov 17;7:507
pubmed: 27909435
Am J Transplant. 2020 Aug;20(8):2081-2090
pubmed: 32034850
Am J Transplant. 2020 Aug;20(8):1963-1964
pubmed: 32189426
J Infect Chemother. 2016 Aug;22(8):505-14
pubmed: 27344206
J Clin Virol. 2017 Sep;94:22-28
pubmed: 28710997
J Leukoc Biol. 2010 Jan;87(1):107-16
pubmed: 19880576
Bone Marrow Transplant. 2016 Mar;51(3):440-2
pubmed: 26551776
Clin Transl Immunology. 2018 Oct 05;7(10):e1040
pubmed: 30323928
Curr Opin Hematol. 2012 Jul;19(4):324-35
pubmed: 22517587
Aging (Albany NY). 2019 Dec 20;11(24):12685-12707
pubmed: 31857499
Virol J. 2013 Jun 11;10:191
pubmed: 23758761
J Clin Virol. 2010 Feb;47(2):189-92
pubmed: 20034850
Front Immunol. 2020 May 27;11:998
pubmed: 32536920
Clin Microbiol Infect. 2016 Jul;22(7):589-93
pubmed: 27093875
Cell. 2013 Nov 21;155(5):1178-87
pubmed: 24267896
Hematol Oncol Clin North Am. 2011 Feb;25(1):151-69
pubmed: 21236396
Biol Blood Marrow Transplant. 2020 Apr;26(4):643-650
pubmed: 31712192
J Clin Virol. 2018 Aug;105:118-127
pubmed: 29957546
Transplantation. 2019 Apr;103(4):660-661
pubmed: 30907854
Clin Microbiol Infect. 2020 Oct;26(10):1406-1410
pubmed: 31972321
Med Microbiol Immunol. 2017 Oct;206(5):355-362
pubmed: 28702856
Front Microbiol. 2018 Nov 29;9:2956
pubmed: 30555452
J Immunol Methods. 2014 Dec 15;415:71-9
pubmed: 25450005
BMJ Open. 2019 Feb 15;9(2):e026093
pubmed: 30772864
Lancet Infect Dis. 2019 Jun;19(6):e200-e212
pubmed: 30744963
J Infect Dis. 2016 Mar 1;213(5):848-55
pubmed: 26410591