Clonal Architecture of
Adult
Aged
Aged, 80 and over
Biomarkers, Tumor
/ antagonists & inhibitors
Carcinoma, Non-Small-Cell Lung
/ diagnosis
Circulating Tumor DNA
/ genetics
Drug Resistance, Neoplasm
/ genetics
ErbB Receptors
/ antagonists & inhibitors
Female
Humans
Lung Neoplasms
/ diagnosis
Male
Middle Aged
Mutation
Neoplasm Staging
Prognosis
Progression-Free Survival
Prospective Studies
Protein Kinase Inhibitors
/ pharmacology
Risk Assessment
/ methods
Journal
Clinical cancer research : an official journal of the American Association for Cancer Research
ISSN: 1557-3265
Titre abrégé: Clin Cancer Res
Pays: United States
ID NLM: 9502500
Informations de publication
Date de publication:
01 02 2021
01 02 2021
Historique:
received:
05
08
2020
revised:
04
10
2020
accepted:
09
11
2020
pubmed:
15
11
2020
medline:
19
1
2022
entrez:
14
11
2020
Statut:
ppublish
Résumé
Clonal architecture is fundamental for the understanding of cancer biology and therapy; however, multiregional sampling in advanced-stage cancers is not always applicable. This prospective clinical trial was to investigate whether paired tissue and circulating tumor DNA (ctDNA) could describe the clonal architecture of advanced non-small cell lung cancer (NSCLC) and its association with clinical outcome (NCT03059641). Paired tumor and plasma ctDNA samples were sequenced by target-capture deep sequencing of 1,021 genes. Clonal dominance analysis was performed on the basis of PyClone. Overall, 300 treatment-naïve patients with stage IIIB-IV NSCLC were recruited from 14 centers. Of the 94 patients with available ctDNA data for Paired tissue and ctDNA could be analyzed for clonal architecture in advanced cancer.
Identifiants
pubmed: 33188140
pii: 1078-0432.CCR-20-3063
doi: 10.1158/1078-0432.CCR-20-3063
doi:
Substances chimiques
Biomarkers, Tumor
0
Circulating Tumor DNA
0
Protein Kinase Inhibitors
0
EGFR protein, human
EC 2.7.10.1
ErbB Receptors
EC 2.7.10.1
Banques de données
ClinicalTrials.gov
['NCT03059641']
Types de publication
Journal Article
Multicenter Study
Observational Study
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
704-712Informations de copyright
©2020 American Association for Cancer Research.
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