Clinical manifestations of adult patients requiring influenza-associated hospitalization: A prospective multicenter cohort study in Japan via internet surveillance.

Adult Aged Hospital Mortality Hospitalization Humans Influenza, Human / drug therapy Internet Japan / epidemiology Prospective Studies Seasons
Elderly Hospitalization Influenza Internet-surveillance system Mortality

Journal

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy
ISSN: 1437-7780
Titre abrégé: J Infect Chemother
Pays: Netherlands
ID NLM: 9608375

Informations de publication

Date de publication:
Mar 2021
Historique:
received: 14 08 2020
revised: 10 10 2020
accepted: 18 10 2020
pubmed: 16 11 2020
medline: 25 6 2021
entrez: 15 11 2020
Statut: ppublish

Résumé

Influenza remains a clinically heavy burden worldwide. The objective of this study was to clarify clinical manifestations of severely ill patients infected with influenza. The clinical data for patients who were severely ill with influenza, and required hospitalization were gathered and analyzed between November 2014 and August 2019 (5 influenza seasons) using an internet-surveillance system. A total of 924 patients were enrolled and analyzed. The median age was 78 years (IQR, 67-84), and the patients in the 2015-2016 season were significantly younger than those in other seasons. Pneumonia was the most common disease indicated as a cause for hospitalization, followed by a poor general condition and exacerbation of underlying respiratory diseases. Antiviral drugs were administered in 97.0% of the patients with peramivir being the most-frequently use antiviral. In-hospital death was recorded for 44 patients (4.8%). Multivariate analysis indicated that nursing home resident (OR: 6.554) and obesity (OR: 24.343) were independent predictors of in-hospital mortality. Complications of influenza infection remain a heavy burden especially among the elderly. Continuous nationwide surveillance will be required to grasp the actual situation of influenza epidemics. (UMIN000015989).

Identifiants

DOI: 10.1016/j.jiac.2020.10.021 PMID: 33189538
pubmed: 33189538
pii: S1341-321X(20)30380-9
doi: 10.1016/j.jiac.2020.10.021
pii:
doi:

Types de publication

Journal Article Multicenter Study

Langues

eng

Sous-ensembles de citation

IM

Pagination

480-485

Informations de copyright

Copyright © 2020 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of competing interest Seki M received scholarship and honorarium from Shionogi Pharmaceutical Co., Ltd. and Daiichi Sankyo Co., Ltd. Fujita J received honorarium from Shionogi Pharmaceutical Co., Ltd. and Daiichi Sankyo Co., Ltd. Kadota J received scholarship from Daiichi Sankyo Co., Ltd. Izumikawa K received scholarship and honorarium from Shionogi Pharmaceutical Co., Ltd. and Daiichi Sankyo Co., Ltd. Kakeya H received scholarship and honorarium from Shionogi Pharmaceutical Co., Ltd. and Daiichi Sankyo Co., Ltd. Watanabe A received honorarium from Shionogi Pharmaceutical Co., Ltd., Daiichi Sankyo Co., Ltd., Taisyo Phar, Co., Ltd., Tanabe Mitsubishi Pharmaceutical Co., Ltd., MSD Co., Ltd., FUJIFILM Toyama Chemical Co., Ltd., and Pfizer Co., Ltd. He received scholarship from Astellas Pharmaceutical Co., Ltd. and Daiicgi Sankyo Co., Ltd. Ishida T, Oishi K, Tateda K, Kawana A, Kikuchi T, Ohmagari N, Yamada M, Maruyama T, Takazono T, Miki M, Miyazaki Y, Yamazaki Y, Ogawa K, Nagai H have no conflict of interest.

Auteurs

Tadashi Ishida (T)

Department of Respiratory Medicine, Ohara Healthcare Foundation, Kurashiki Central Hospital, 1-1-1, Kurashiki, Okayama, 710-8602, Japan. Electronic address: ishidat@kchnet.or.jp.

Masafumi Seki (M)

Department of Infectious Diseases, Tohoku Medical and Pharmaceutical University, 4-4-1, Komatsushima, Aobaku, Sendai, Miyagi, 981-8558, Japan.

Kazunori Oishi (K)

Toyama Institute of Health, 17-1, Nakataikouyama, Imizu, Toyama, 939-0363, Japan.

Kazuhiro Tateda (K)

Department of Microbiology and Infectious Diseases, Toho University, 5-21-6, Omorinishi, Ota-ku, Tokyo, 143-8540, Japan.

Jiro Fujita (J)

Department of Infectious, Respiratory, and Digestive Medicine, University of the Ryukyus, 207 Azaujihara, Nisiharacho, Nakatou, Okinawa, 903-0215, Japan.

Jun-Ichi Kadota (JI)

Nagasaki City Hospital Organization, Nagasaki Harbor Medical Center, 6-39, Shinchicho, Nagasaki, 850-8555, Japan.

Akihiko Kawana (A)

Division of Infectious Diseases and Respiratory Medicine, National Defense Medical College, Namiki, Tokorozawa, Saitama, 359-8513, Japan.

Koichi Izumikawa (K)

Department of Infectious Diseases, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1, Sakamoto, Nagasaki, 852-8501, Japan.

Toshiaki Kikuchi (T)

Department of Respiratory Medicine and Infectious Diseases, Niigata University Graduate School of Medical and Dental Sciences, 751, Ichibancho, Asahimachi-dori, Chuo-ku, Niigata, 951-8510, Japan.

Norio Ohmagari (N)

Disease Control and Prevention Center, National Center for Global Health and Medicine, 1-21-1, Toyama, Shinjuku-ku, Tokyo, 162-8655, Japan.

Mitsuhiro Yamada (M)

Department of Respiratory Medicine, Tohoku University Graduate School of Medicine, 1-1, Seiryocho, Aoba-ku, Sendai, Miyagi, 980-8574, Japan.

Takaya Maruyama (T)

Department of Respiratory Medicine, National Hospital Organization Mie National Hospital, 357, Kubotacho, Osato, Tsu, Mie, 514-0125, Japan.

Takahiro Takazono (T)

Department of Infectious Diseases, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1, Sakamoto, Nagasaki, 852-8501, Japan.

Makoto Miki (M)

Department of Pulmonary and Respiratory Medicine, Japanese Red Cross Sendai Hospital, 2-43-3, Yamamotocho, Yagi, Taihaku-ku, Sendai, 982-8501, Japan.

Yoshitsugu Miyazaki (Y)

Department of Chemotherapy and Mycoses, Leprosy Research Center, National Institute of Infectious Diseases, 1-23-1, Toyama, Shinjuku-ku, Tokyo, 162-8640, Japan.

Yoshitaka Yamazaki (Y)

Division of Infectious Diseases, Shinsyu Medical Center, 1332, Suzaka, Nagano, 382-0091, Japan.

Hiroshi Kakeya (H)

Department of Infectious Control Science, Osaka City University Graduate School of Medicine, 1-4-3, Asahimachi, Abeno-ku, Osaka, 545-8585, Japan.

Kenji Ogawa (K)

Department of Respiratory Medicine, National Hospital Organization Higashinagoya National Hospital, 5-101, Umemorizaka, Higashi-ku, Nagoya, Aichi, 465-8620, Japan.

Hideaki Nagai (H)

Department of Infectious Diseases, National Hospital Organization, Tokyo National Hospital, 3-1-1, Takeoka, Kiyose, Tokyo, 204-8585, Japan.

Akira Watanabe (A)

Division for Development of Anti-infective Agents, Faculty of Medical Science and Welfare, Tohoku Bunka Gakuen University, 6-45-1, Kunimi, Aoba-ku, Sendai, 981-8551, Japan.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Clinical manifestations of adult patients...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Clinical manifestations of adult patients...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Collecte de données › Registre civil › Mortalité › Mortalité hospitalière › Clinical manifestations of adult patients...
questionsmedicales.fr › Établissements, main d'oeuvre et services de soins de santé › Services de santé › Soins aux patients › Hospitalisation › Clinical manifestations of adult patients...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Clinical manifestations of adult patients...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Infections de l'appareil respiratoire › Grippe humaine › Clinical manifestations of adult patients...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Systèmes informatiques › Réseaux de communication entre ordinateurs › Internet › Clinical manifestations of adult patients...
questionsmedicales.fr › Régions géographiques › Iles › Japon › Clinical manifestations of adult patients...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études prospectives › Clinical manifestations of adult patients...
questionsmedicales.fr › Environnement et santé publique › Environnement › Concepts météorologiques › Atmosphère › Climat › Saisons › Clinical manifestations of adult patients...