Pre-clinical and Clinical Implications of "Inside-Out" vs. "Outside-In" Paradigms in Multiple Sclerosis Etiopathogenesis.
animal models
autoimmunity
demyelination
etiopathogenesis
multiple sclerosis
Journal
Frontiers in cellular neuroscience
ISSN: 1662-5102
Titre abrégé: Front Cell Neurosci
Pays: Switzerland
ID NLM: 101477935
Informations de publication
Date de publication:
2020
2020
Historique:
received:
27
08
2020
accepted:
06
10
2020
entrez:
16
11
2020
pubmed:
17
11
2020
medline:
17
11
2020
Statut:
epublish
Résumé
Multiple Sclerosis (MS) is an immune-mediated neurological disorder, characterized by central nervous system (CNS) inflammation, oligodendrocyte loss, demyelination, and axonal degeneration. Although autoimmunity, inflammatory demyelination and neurodegeneration underlie MS, the initiating event has yet to be clarified. Effective disease modifying therapies need to both regulate the immune system and promote restoration of neuronal function, including remyelination. The challenge in developing an effective long-lived therapy for MS requires that three disease-associated targets be addressed: (1) self-tolerance must be re-established to specifically inhibit the underlying myelin-directed autoimmune pathogenic mechanisms; (2) neurons must be protected from inflammatory injury and degeneration; (3) myelin repair must be engendered by stimulating oligodendrocyte progenitors to remyelinate CNS neuronal axons. The combined use of chronic and relapsing remitting experimental autoimmune encephalomyelitis (C-EAE, R-EAE) ("outside-in") as well as progressive diphtheria toxin A chain (
Identifiants
pubmed: 33192332
doi: 10.3389/fncel.2020.599717
pmc: PMC7654287
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
599717Subventions
Organisme : NINDS NIH HHS
ID : R01 NS062365
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS034939
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS109372
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS099334
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS067550
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI142059
Pays : United States
Informations de copyright
Copyright © 2020 Titus, Chen, Podojil, Robinson, Balabanov, Popko and Miller.
Références
Immunol Today. 1993 May;14(5):203-8
pubmed: 7686009
mBio. 2015 Jun 16;6(3):e02513
pubmed: 26081637
Neurosci Lett. 2011 Jul 25;499(3):143-8
pubmed: 21669255
Brain Res Bull. 2007 Oct 19;74(5):307-16
pubmed: 17845905
Brain. 1997 Mar;120 ( Pt 3):393-9
pubmed: 9126051
J Clin Invest. 2007 Feb;117(2):448-56
pubmed: 17273557
Ann Neurol. 2009 Mar;65(3):239-48
pubmed: 19334069
Nat Commun. 2015 Mar 13;6:6532
pubmed: 25766071
Mult Scler. 2014 Apr;20(4):471-80
pubmed: 23950550
Proc Natl Acad Sci U S A. 2006 Mar 21;103(12):4422-7
pubmed: 16537438
J Immunol. 2011 Sep 1;187(5):2405-17
pubmed: 21821796
Neurology. 2014 Dec 9;83(24):2227-31
pubmed: 25378668
J Head Trauma Rehabil. 2009 Nov-Dec;24(6):439-51
pubmed: 19940677
J Clin Invest. 1994 Jul;94(1):146-54
pubmed: 7518827
Neurology. 1992 Feb;42(2):367-70
pubmed: 1736167
Nat Neurosci. 2012 Feb 26;15(4):543-50
pubmed: 22366759
Curr Neurol Neurosci Rep. 2013 Nov;13(11):394
pubmed: 24061646
Nat Rev Immunol. 2002 Feb;2(2):85-95
pubmed: 11910899
ASN Neuro. 2011 Apr 07;3(2):
pubmed: 21382015
Brain. 2019 Feb 1;142(2):344-361
pubmed: 30657878
J Pharmacol Exp Ther. 2003 Apr;305(1):70-7
pubmed: 12649354
Acta Neuropathol. 2017 Feb;133(2):223-244
pubmed: 27766432
Annu Rev Biomed Eng. 2016 Jul 11;18:181-205
pubmed: 26928211
J Cell Biol. 2005 May 23;169(4):603-12
pubmed: 15911877
Neuropathol Appl Neurobiol. 1987 Nov-Dec;13(6):451-65
pubmed: 3328828
Immunity. 2007 Aug;27(2):203-13
pubmed: 17707129
J Steroid Biochem Mol Biol. 2017 May;169:29-38
pubmed: 26921765
Am J Pathol. 2008 Nov;173(5):1508-17
pubmed: 18818381
Immunol Rev. 2009 May;229(1):337-55
pubmed: 19426232
Cell. 2010 Mar 19;140(6):918-34
pubmed: 20303880
Nat Med. 2018 Dec;24(12):1837-1844
pubmed: 30420755
Nat Genet. 2013 Nov;45(11):1353-60
pubmed: 24076602
Immunology. 2010 Feb;129(2):154-69
pubmed: 20561356
Genesis. 2003 Jan;35(1):63-72
pubmed: 12481300
J Neurosci. 2012 Jun 13;32(24):8317-30
pubmed: 22699912
Proc Natl Acad Sci U S A. 1996 Mar 19;93(6):2499-504
pubmed: 8637903
Cells. 2019 Oct 24;8(11):
pubmed: 31653054
Nanomedicine. 2017 Jan;13(1):191-200
pubmed: 27720992
J Immunol Methods. 1979;28(3-4):361-8
pubmed: 479609
Front Cell Neurosci. 2020 Mar 10;14:43
pubmed: 32210765
J Clin Med. 2018 Oct 11;7(10):
pubmed: 30314286
Ann Neurol. 2006 May;59(5):743-7
pubmed: 16634029
J Neurol Sci. 2010 Mar 15;290(1-2):70-4
pubmed: 19945717
Pediatr Neurol. 1996 Sep;15(2):103-7
pubmed: 8888042
Neurology. 2019 Mar 5;92(10):469-480
pubmed: 30770422
Neurol Ther. 2020 Jun;9(1):55-66
pubmed: 32297127
Ann Neurol. 2005 Sep;58(3):470-3
pubmed: 16130097
Arch Pharm Res. 2010 Oct;33(10):1567-74
pubmed: 21052934
Nat Rev Immunol. 2009 Jun;9(6):440-7
pubmed: 19444308
Curr Opin Neurol. 2011 Jun;24(3):224-9
pubmed: 21455066
Handb Clin Neurol. 2014;122:173-89
pubmed: 24507518
J Vet Diagn Invest. 2004 Sep;16(5):403-11
pubmed: 15460322
Nat Rev Drug Discov. 2010 Nov;9(11):883-97
pubmed: 21031003
Cell Microbiol. 2015 Mar;17(3):369-88
pubmed: 25287162
Int J Mol Sci. 2015 Jun 17;16(6):13885-907
pubmed: 26090715
J Neuroimmunol. 2014 Aug 15;273(1-2):85-95
pubmed: 24907905
Immunity. 2008 Jan;28(1):122-33
pubmed: 18164221
Mult Scler. 2019 Apr;25(5):653-660
pubmed: 29681209
Proc Natl Acad Sci U S A. 2019 May 7;116(19):9671-9676
pubmed: 31004050
Ann Neurol. 2004 Apr;55(4):458-68
pubmed: 15048884
J Neurotrauma. 2018 Mar 1;35(5):739-749
pubmed: 29228858
J Neuropathol Exp Neurol. 1992 Nov;51(6):630-43
pubmed: 1362438
J Exp Med. 1995 Dec 1;182(6):1985-96
pubmed: 7500044
Brain Pathol. 2001 Jan;11(1):107-16
pubmed: 11145196
Lancet Neurol. 2017 Nov;16(11):925-933
pubmed: 28969984
Nat Med. 1997 Oct;3(10):1133-6
pubmed: 9334726
J Cereb Blood Flow Metab. 2014 Apr;34(4):715-23
pubmed: 24473478
Toxins (Basel). 2020 Jan 06;12(1):
pubmed: 31935961
J Neurotrauma. 2018 Apr 15;35(8):1015-1020
pubmed: 29239261
Rev Neurosci. 2013;24(1):71-88
pubmed: 23152401
J Comp Neurol. 2005 Jun 6;486(3):243-53
pubmed: 15844172
Nat Rev Endocrinol. 2016 Oct;12(10):606-15
pubmed: 27312864
Nat Rev Immunol. 2009 Apr;9(4):246-58
pubmed: 19319143
Immunol Rev. 1995 Apr;144:225-44
pubmed: 7590815
J Neurosci. 2013 Apr 3;33(14):5980-91
pubmed: 23554479
Annu Rev Neurosci. 2002;25:491-505
pubmed: 12052918
Trends Mol Med. 2010 Aug;16(8):379-86
pubmed: 20591737
Neurotherapeutics. 2017 Oct;14(4):859-873
pubmed: 28812220
Neuron. 2009 Oct 15;64(1):123-32
pubmed: 19840554
J Exp Med. 1940 Jun 30;72(1):79-90
pubmed: 19871009
J Virol. 2013 Jan;87(1):512-23
pubmed: 23097433
Annu Rev Immunol. 2005;23:683-747
pubmed: 15771584
Nat Rev Neurosci. 2008 Nov;9(11):839-55
pubmed: 18931697
Ann Neurol. 2012 Jul;72(1):18-31
pubmed: 22829266
Vet Microbiol. 2008 Sep 18;131(1-2):14-25
pubmed: 18406080
Neurology. 2019 Mar 5;92(10):e1016-e1028
pubmed: 30770432
Rev Diabet Stud. 2012 Winter;9(4):319-27
pubmed: 23804269
Neuropharmacology. 2016 Nov;110(Pt B):654-659
pubmed: 25963414
Nature. 1992 Jul 9;358(6382):155-7
pubmed: 1377368
J Neuroimmunol. 2007 Jan;182(1-2):5-12
pubmed: 17125847
Immunol Rev. 1998 Aug;164:53-61
pubmed: 9795763
J Vet Diagn Invest. 2008 May;20(3):253-65
pubmed: 18460610
J Biol Chem. 2002 Jun 14;277(24):21453-7
pubmed: 11967257
Nanomedicine. 2019 Jun;18:282-291
pubmed: 30352312
J Proteomics. 2018 Sep 15;187:212-222
pubmed: 30086402
Proc Natl Acad Sci U S A. 1991 Mar 15;88(6):2466-70
pubmed: 1706524
Acta Neuropathol. 2015 Aug;130(2):279-95
pubmed: 25920452
J Inherit Metab Dis. 1992;15(4):645-64
pubmed: 1528023
Eur J Immunol. 2010 Oct;40(10):2942-56
pubmed: 20812237
Proc Natl Acad Sci U S A. 2018 Sep 25;115(39):9773-9778
pubmed: 30194232
Nat Rev Neurosci. 2012 Jun 20;13(7):507-14
pubmed: 22714021
Neurosci Biobehav Rev. 2019 Dec;107:23-46
pubmed: 31442519
Front Neurol. 2018 Jan 23;9:5
pubmed: 29410647
Brain. 2017 Jul 1;140(7):1900-1913
pubmed: 28541408
PLoS One. 2013 Oct 16;8(10):e76359
pubmed: 24146858
Neurology. 2019 Mar 5;92(10):e1029-e1040
pubmed: 30770430
Neurology. 2019 Oct 8;93(15):e1452-e1462
pubmed: 31515290
Neurol Clin Pract. 2018 Apr;8(2):156-158
pubmed: 29708222
Lancet Neurol. 2020 Apr;19(4):336-347
pubmed: 32059809
Ann Neurol. 1996 Jul;40(1):18-24
pubmed: 8687186
Autoimmun Rev. 2002 Oct;1(5):251-60
pubmed: 12848977
Exp Neurol. 2016 Jan;275 Pt 3:328-333
pubmed: 25697845
CNS Neurosci Ther. 2018 May;24(5):412-419
pubmed: 29316271
Toxicon. 2001 Nov;39(11):1793-803
pubmed: 11595641
J Exp Med. 1995 Jul 1;182(1):75-85
pubmed: 7540658
Expert Opin Drug Saf. 2017 Aug;16(8):963-972
pubmed: 28641055
Biochemistry. 1999 May 11;38(19):6157-63
pubmed: 10320343
J Mol Med (Berl). 2019 Apr;97(4):463-472
pubmed: 30820593
J Neuroimmunol. 2013 Oct 15;263(1-2):13-9
pubmed: 23916696
J Clin Invest. 1995 Sep;96(3):1455-63
pubmed: 7657817
Front Cell Neurosci. 2017 Feb 13;11:24
pubmed: 28243193
ACS Nano. 2014 Mar 25;8(3):2148-60
pubmed: 24559284
J Clin Invest. 2001 Jul;108(2):311-8
pubmed: 11457884
AJNR Am J Neuroradiol. 2008 Oct;29(9):1730-5
pubmed: 18617586
Nat Neurosci. 2016 Jan;19(1):65-74
pubmed: 26656646
J Lipid Res. 2009 Jan;50(1):135-47
pubmed: 18723473
Nature. 2010 Nov 11;468(7321):244-52
pubmed: 21068833
Brain. 2010 Oct;133(10):3017-29
pubmed: 20851998
Aust Vet J. 2003 Apr;81(4):219-21
pubmed: 15080445
Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2014 May-Jun;6(3):298-315
pubmed: 24616452
Ann Neurol. 2001 Nov;50(5):646-57
pubmed: 11706971
Annu Rev Neurosci. 2008;31:247-69
pubmed: 18558855
PLoS One. 2015 Jun 08;10(6):e0129217
pubmed: 26053248
Infect Immun. 2003 Sep;71(9):5371-5
pubmed: 12933886
J Clin Neurosci. 2019 Mar;61:112-113
pubmed: 30396814
J Struct Biol. 2000 Feb;129(1):80-95
pubmed: 10675299
Lancet Neurol. 2007 Oct;6(10):903-12
pubmed: 17884680
Neurochem Res. 2006 Aug;31(8):1045-54
pubmed: 16871440
Nat Commun. 2014 Dec 01;5:5472
pubmed: 25434649
Nat Immunol. 2007 Sep;8(9):913-9
pubmed: 17712344
J Chem Biol. 2015 Jun 12;9(1):9-18
pubmed: 26855677
Neuroscientist. 2014 Jan 6;20(4):343-358
pubmed: 24395337
Proc Natl Acad Sci U S A. 2018 May 22;115(21):5528-5533
pubmed: 29728463
Proc Natl Acad Sci U S A. 2011 Jan 11;108(2):751-6
pubmed: 21177428
Nat Clin Pract Neurol. 2007 Mar;3(3):140-51
pubmed: 17342190
PLoS Pathog. 2015 May 20;11(5):e1004896
pubmed: 25993478
J Neurosci. 2007 Feb 21;27(8):2013-24
pubmed: 17314297
Dev Neurobiol. 2009 Jan;69(1):60-72
pubmed: 19025930
Nat Med. 2005 Mar;11(3):335-9
pubmed: 15735651
Brain. 2011 Mar;134(Pt 3):678-92
pubmed: 21354971
Discov Med. 2013 Aug;16(86):53-63
pubmed: 23911232
Nat Biotechnol. 2012 Dec;30(12):1217-24
pubmed: 23159881
Nat Rev Neurol. 2017 Nov;13(11):640
pubmed: 28914886
Science. 2019 Sep 27;365(6460):
pubmed: 31604244
J Neuroimmunol. 1991 Jul;33(1):55-62
pubmed: 1711538
Bioessays. 2003 Nov;25(11):1106-18
pubmed: 14579251
Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):3143-8
pubmed: 23382229
Sci Transl Med. 2013 Jun 5;5(188):188ra75
pubmed: 23740901
Science. 2002 Apr 12;296(5566):346-9
pubmed: 11923495
J Exp Med. 1989 Nov 1;170(5):1671-80
pubmed: 2478653
Adv Drug Deliv Rev. 2017 May 15;114:240-255
pubmed: 28414079
J Neuroimmunol. 2003 Nov;144(1-2):68-79
pubmed: 14597100
Neurobiol Dis. 2015 Apr;76:57-66
pubmed: 25680941
J Immunol. 2013 Dec 1;191(11):5341-6
pubmed: 24244028
FEBS J. 2011 Dec;278(23):4602-15
pubmed: 21535407
J Comp Pathol. 1984 Jul;94(3):445-52
pubmed: 6088599
Neurology. 1993 Feb;43(2):403-7
pubmed: 7679782
Brain Pathol. 2010 Jul;20(4):817-30
pubmed: 20626743
PLoS One. 2015 Mar 23;10(3):e0121541
pubmed: 25798924
J Neuropathol Exp Neurol. 2001 Oct;60(10):1004-19
pubmed: 11589421
PLoS One. 2011;6(7):e22735
pubmed: 21818378
Can J Comp Med. 1983 Apr;47(2):127-32
pubmed: 6309346
Neurochem Res. 2007 Feb;32(2):251-6
pubmed: 17031564
Cell Rep. 2019 Oct 29;29(5):1178-1191.e6
pubmed: 31665632
Scand J Immunol. 1993 Mar;37(3):355-68
pubmed: 7680141
J Neuroimmunol. 1991 Dec;35(1-3):227-36
pubmed: 1720135
J Neuropathol Exp Neurol. 2015 Mar;74(3):218-32
pubmed: 25668562
J Immunol. 1991 Mar 1;146(5):1490-5
pubmed: 1899688
J Exp Neurosci. 2018 Nov 14;12:1179069518810004
pubmed: 30479489
J Neuroimmunol. 2016 Feb 15;291:1-10
pubmed: 26857488
Ann Neurol. 2011 Sep;70(3):362-73
pubmed: 21674589
Med Hypotheses. 1986 Jan;19(1):27-39
pubmed: 2871478
Nat Immunol. 2007 Feb;8(2):172-80
pubmed: 17206145
PLoS One. 2010 Sep 30;5(9):
pubmed: 20941361
Ann Neurol. 2020 Mar;87(3):442-455
pubmed: 31925846
Methods Mol Biol. 2016;1304:145-60
pubmed: 25005074