A Layer 3→5 Circuit in Auditory Cortex That Contributes to Pre-pulse Inhibition of the Acoustic Startle Response.
auditory cortex
canonical microcircuit
gap detection
layer 3
startle response modulation
Journal
Frontiers in neural circuits
ISSN: 1662-5110
Titre abrégé: Front Neural Circuits
Pays: Switzerland
ID NLM: 101477940
Informations de publication
Date de publication:
2020
2020
Historique:
received:
17
04
2020
accepted:
28
09
2020
entrez:
16
11
2020
pubmed:
17
11
2020
medline:
5
10
2021
Statut:
epublish
Résumé
While connectivity within sensory cortical circuits has been studied extensively, how these connections contribute to perception and behavior is not well understood. Here we tested the role of a circuit between layers 3 and 5 of auditory cortex in sound detection. We measured sound detection using a common variant of pre-pulse inhibition of the acoustic startle response, in which a silent gap in background noise acts as a cue that attenuates startle. We used the Nr5a-Cre driver line, which we found drove expression in the auditory cortex restricted predominantly to layer 3. Photoactivation of these cells evoked short-latency, highly reliable spiking in downstream layer 5 neurons, and attenuated startle responses similarly to gaps in noise. Photosuppression of these cells did not affect behavioral gap detection. Our data provide the first demonstration that direct activation of auditory cortical neurons is sufficient to attenuate the acoustic startle response, similar to the detection of a sound.
Identifiants
pubmed: 33192336
doi: 10.3389/fncir.2020.553208
pmc: PMC7661757
doi:
Substances chimiques
Steroidogenic Factor 1
0
steroidogenic factor 1, mouse
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
553208Subventions
Organisme : NIDCD NIH HHS
ID : R01 DC015828
Pays : United States
Informations de copyright
Copyright © 2020 Weible, Yavorska, Kayal, Duckler and Wehr.
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