Resveratrol and artemisinin eudragit-coated liposomes: A strategy to tackle intestinal tumors.

Artemisinins Humans Intestinal Neoplasms Liposomes Polymethacrylic Acids Resveratrol
Antitumor Artemisinin Eudragit Intestinal delivery Liposomes Resveratrol

Journal

International journal of pharmaceutics
ISSN: 1873-3476
Titre abrégé: Int J Pharm
Pays: Netherlands
ID NLM: 7804127

Informations de publication

Date de publication:
05 Jan 2021
Historique:
received: 15 09 2020
revised: 06 11 2020
accepted: 08 11 2020
pubmed: 17 11 2020
medline: 22 6 2021
entrez: 16 11 2020
Statut: ppublish

Résumé

Resveratrol and artemisinin, two naturally occurring compounds with a wide range of biological activities, have been reported to exert antitumor effects against several types of cancer. In this work, Eudragit-coated liposomes were developed to safely transport resveratrol and artemisinin through the gastrointestinal tract and target the intestine. The physico-chemical properties of the Eudragit-coated liposomes were assessed by light scattering and cryogenic transmission electron microscopy. Nanosized (around 100 nm), spherical or elongated, unilamellar vesicles were produced. The protective effect of the Eudragit coating was confirmed by assessing the physical stability of the vesicles in fluids mimicking the gastrointestinal environment. Furthermore, the vesicles were found to exert a pro-oxidant activity in intestinal adenocarcinoma cells, which resulted in a marked mortality due to the generation of reactive oxygen species (ROS). A time- and dose-dependent cell growth inhibitory effect was detected, with elevated ROS levels when resveratrol and artemisinin were combined. Therefore, the proposed formulations may represent a valuable means to counteract intestinal tumor growth.

Identifiants

DOI: 10.1016/j.ijpharm.2020.120083 PMID: 33197563
pubmed: 33197563
pii: S0378-5173(20)31068-1
doi: 10.1016/j.ijpharm.2020.120083
pii:
doi:

Substances chimiques

Artemisinins 0
Liposomes 0
Polymethacrylic Acids 0
methylmethacrylate-methacrylic acid copolymer 25086-15-1
Resveratrol Q369O8926L

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

120083

Informations de copyright

Copyright © 2020 Elsevier B.V. All rights reserved.

Auteurs

Carla Caddeo (C)

Dept. of Scienze della Vita e dell'Ambiente, Sezione di Scienze del Farmaco, University of Cagliari, Via Ospedale 72, 09124 Cagliari, Italy. Electronic address: caddeoc@unica.it.

Morena Gabriele (M)

Institute of Agricultural Biology and Biotechnology, CNR Pisa, Via Moruzzi 1, 56124 Pisa, Italy.

Amparo Nácher (A)

Dept. of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of Valencia, Vicente Andrés Estellés s/n, 46100 Valencia, Spain; Instituto Interuniversitario de Investigación de Reconocimiento Molecular y Desarrollo Tecnológico (IDM), Universitat Politècnica de València, Universitat de València, Valencia, Spain.

Xavier Fernàndez-Busquets (X)

Nanomalaria Group, Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute of Science and Technology, Baldiri Reixac 10-12, Barcelona E08028, Spain; Barcelona Institute for Global Health (ISGlobal), Hospital Clínic-Universitat de Barcelona, Rosselló 149-153, Barcelona E08036, Spain.

Donatella Valenti (D)

Dept. of Scienze della Vita e dell'Ambiente, Sezione di Scienze del Farmaco, University of Cagliari, Via Ospedale 72, 09124 Cagliari, Italy.

Anna Maria Fadda (A)

Dept. of Scienze della Vita e dell'Ambiente, Sezione di Scienze del Farmaco, University of Cagliari, Via Ospedale 72, 09124 Cagliari, Italy.

Laura Pucci (L)

Institute of Agricultural Biology and Biotechnology, CNR Pisa, Via Moruzzi 1, 56124 Pisa, Italy. Electronic address: laura.pucci@ibba.cnr.it.

Maria Manconi (M)

Dept. of Scienze della Vita e dell'Ambiente, Sezione di Scienze del Farmaco, University of Cagliari, Via Ospedale 72, 09124 Cagliari, Italy.

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Classifications MeSH

questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Terpènes › Sesquiterpènes › Artémisinines › Resveratrol and artemisinin eudragit-coated...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Resveratrol and artemisinin eudragit-coated...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies gastro-intestinales › Maladies intestinales › Tumeurs de l'intestin › Resveratrol and artemisinin eudragit-coated...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Matériaux biomimétiques › Membrane artificielle › Liposomes › Resveratrol and artemisinin eudragit-coated...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Matériaux biomédicaux et dentaires › Polymères › Matières plastiques › Résines synthétiques › Résines acryliques › Poly(acides méthacryliques) › Resveratrol and artemisinin eudragit-coated...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures cycliques › Hydrocarbures aromatiques › Dérivés du benzène › Phénols › Polyphénols › Resvératrol › Resveratrol and artemisinin eudragit-coated...