Molecular Biomarkers for Celiac Disease: Past, Present and Future.
celiac disease
diagnosis
follow-up
new biomarkers
non-invasive
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
12 Nov 2020
12 Nov 2020
Historique:
received:
21
10
2020
accepted:
10
11
2020
entrez:
17
11
2020
pubmed:
18
11
2020
medline:
7
4
2021
Statut:
epublish
Résumé
Celiac disease (CeD) is a complex immune-mediated disorder that is triggered by dietary gluten in genetically predisposed individuals. CeD is characterized by inflammation and villous atrophy of the small intestine, which can lead to gastrointestinal complaints, malnutrition, and malignancies. Currently, diagnosis of CeD relies on serology (antibodies against transglutaminase and endomysium) and small-intestinal biopsies. Since small-intestinal biopsies require invasive upper-endoscopy, and serology cannot predict CeD in an early stage or be used for monitoring disease after initiation of a gluten-free diet, the search for non-invasive biomarkers is ongoing. Here, we summarize current and up-and-coming non-invasive biomarkers that may be able to predict, diagnose, and monitor the progression of CeD. We further discuss how current and emerging techniques, such as (single-cell) transcriptomics and genomics, can be used to uncover the pathophysiology of CeD and identify non-invasive biomarkers.
Identifiants
pubmed: 33198309
pii: ijms21228528
doi: 10.3390/ijms21228528
pmc: PMC7697360
pii:
doi:
Substances chimiques
Biomarkers
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : CONACyT-I2T2
ID : 459192
Organisme : Netherlands Organization for Scientific Research (NWO) VIDI
ID : no. 016.171.047
Organisme : Netherlands Organ-on-Chip Initiative, an NWO Gravitation project
ID : 024.003.001
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