Sebo Withoff

Affiliations

Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

ORCID: https://orcid.org/0000-0001-7704-3437

Publications (24)

Potential impact of celiac disease genetic risk factors on T cell receptor signaling in gluten-specific CD4+ T cells.

Scientific reports

Avec: Olivier B Bakker , Aarón D Ramírez-Sánchez , Zuzanna A Borek , Niek de Klein , Yang Li , Rutger Modderman , Yvonne Kooy-Winkelaar , Marie K Johannesen , Filomena Matarese , Joost H A Martens , Vinod Kumar , Jeroen van Bergen , Shuo-Wang Qiao , Knut E A Lundin , Ludvig M Sollid , Frits Koning , Cisca Wijmenga , Sebo Withoff , Iris H Jonkers

Inflammatory Protein Profiles in Plasma of Candidaemia Patients and the Contribution of Host Genetics to Their Variability.

Frontiers in immunology

Avec: Vasiliki Matzaraki , Kieu T T Le , Martin Jaeger , Raúl Aguirre-Gamboa , Melissa D Johnson , Serena Sanna , Diletta Rosati , Lude Franke , Alexandra Zhernakova , Jingyuan Fu , Sebo Withoff , Iris Jonkers , Yang Li , Leo A B Joosten , Mihai G Netea , Cisca Wijmenga , Vinod Kumar

Single-Cell RNA Sequencing of Peripheral Blood Mononuclear Cells From Pediatric Coeliac Disease Patients Suggests Potential Pre-Seroconversion Markers.

Frontiers in immunology

Avec: Aarón D Ramírez-Sánchez , Xiaojing Chu , Rutger Modderman , Yvonne Kooy-Winkelaar , Sibylle Koletzko , Ilma R Korponay-Szabó , Riccardo Troncone , Cisca Wijmenga , Luisa Mearin , Sebo Withoff , Iris H Jonkers , Yang Li

iPSC-derived organ-on-a-chip models for personalized human genetics and pharmacogenomics studies.

Trends in genetics : TIG

Avec: Victoria E J M Palasantzas , Isabel Tamargo-Rubio , Kieu Le , Jelle Slager , Cisca Wijmenga , Iris H Jonkers , Vinod Kumar , Jingyuan Fu , Sebo Withoff

A Genome-Wide Functional Genomics Approach Identifies Susceptibility Pathways to Fungal Bloodstream Infection in Humans.

The Journal of infectious diseases

Avec: Martin Jaeger , Vasiliki Matzaraki , Raúl Aguirre-Gamboa , Mark S Gresnigt , Xiaojing Chu , Melissa D Johnson , Marije Oosting , Sanne P Smeekens , Sebo Withoff , Iris Jonkers , John R Perfect , Frank L van de Veerdonk , Bart-Jan Kullberg , Leo A B Joosten , Yang Li , Cisca Wijmenga , Mihai G Netea , Vinod Kumar

Leukocyte-Released Mediators in Response to Both Bacterial and Fungal Infections Trigger IFN Pathways, Independent of IL-1 and TNF-α, in Endothelial Cells.

Frontiers in immunology

Avec: Kieu T T Le , Xiaojing Chu , Martin Jaeger , Josée A Plantinga , Vasiliki Matzaraki , Sebo Withoff , Leo A B Joosten , Mihai G Netea , Cisca Wijmenga , Yang Li , Jill Moser , Vinod Kumar

Circulating miRNAs as Potential Biomarkers for Celiac Disease Development.

Frontiers in immunology

Avec: Ineke L Tan , Rodrigo Coutinho de Almeida , Rutger Modderman , Anna Stachurska , Jackie Dekens , Donatella Barisani , Caroline R Meijer , María Roca , Eva Martinez-Ojinaga , Raanan Shamir , Renata Auricchio , Ilma R Korponay-Szabó , Gemma Castillejo , Hania Szajewska , Sibylle Koletzko , Alexandra Zhernakova , Vinod Kumar , Yang Li , Marijn C Visschedijk , Rinse K Weersma , Riccardo Troncone , M Luisa Mearin , Cisca Wijmenga , Iris Jonkers , Sebo Withoff

An iPSC-derived small intestine-on-chip with self-organizing epithelial, mesenchymal, and neural cells.

Cell reports

Avec: Renée Moerkens , Joram Mooiweer , Aarón D Ramírez-Sánchez , Roy Oelen , Lude Franke , Cisca Wijmenga , Robert J Barrett , Iris H Jonkers , Sebo Withoff

Long Non-Coding RNAs Involved in Progression of Non-Alcoholic Fatty Liver Disease to Steatohepatitis.

Cells

Avec: Biljana Atanasovska , Sander S Rensen , Glenn Marsman , Ronit Shiri-Sverdlov , Sebo Withoff , Folkert Kuipers , Cisca Wijmenga , Bart van de Sluis , Jingyuan Fu

Gut mucosa dissociation protocols influence cell type proportions and single-cell gene expression levels.

Scientific reports

Avec: Werna T C Uniken Venema , Aarón D Ramírez-Sánchez , Emilia Bigaeva , Sebo Withoff , Iris Jonkers , Rebecca E McIntyre , Mennatallah Ghouraba , Tim Raine , Rinse K Weersma , Lude Franke , Eleonora A M Festen , Monique G P van der Wijst

Genetic mapping across autoimmune diseases reveals shared associations and mechanisms.

Nature genetics

Avec: Matthew R Lincoln , Noah Connally , Pierre-Paul Axisa , Christiane Gasperi , Mitja Mitrovic , David van Heel , Cisca Wijmenga , Sebo Withoff , Iris H Jonkers , Leonid Padyukov , Auteur inconnu , Stephen S Rich , Robert R Graham , Patrick M Gaffney , Carl D Langefeld , Timothy J Vyse , David A Hafler , Sung Chun , Shamil R Sunyaev , Chris Cotsapas

Potential biomarkers for multiple sclerosis stage from targeted proteomics and microRNA sequencing.

Brain communications

Avec: Ineke L Tan , Rutger Modderman , Anna Stachurska , Rodrigo Almeida , Riemer de Vries , Dorothea J Heersema , Ranko Gacesa , Cisca Wijmenga , Iris H Jonkers , Jan F Meilof , Sebo Withoff

Human organoids and organ-on-chips in coeliac disease research.

Trends in molecular medicine

Avec: Hanna L Simpson , Eline Smits , Renée Moerkens , Cisca Wijmenga , Joram Mooiweer , Iris H Jonkers , Sebo Withoff

Deconvolution of bulk blood eQTL effects into immune cell subpopulations.

BMC bioinformatics

Avec: Raúl Aguirre-Gamboa , Niek de Klein , Jennifer di Tommaso , Annique Claringbould , Monique Gp van der Wijst , Dylan de Vries , Harm Brugge , Roy Oelen , Urmo Võsa , Maria M Zorro , Xiaojin Chu , Olivier B Bakker , Zuzanna Borek , Isis Ricaño-Ponce , Patrick Deelen , Cheng-Jiang Xu , Morris Swertz , Iris Jonkers , Sebo Withoff , Irma Joosten , Serena Sanna , Vinod Kumar , Hans J P M Koenen , Leo A B Joosten , Mihai G Netea , Cisca Wijmenga , Auteur inconnu , Lude Franke , Yang Li

Non-classical clinical presentation at diagnosis by male celiac disease patients of older age.

European journal of internal medicine

Avec: Ineke L Tan , Sebo Withoff , Jeroen J Kolkman , Cisca Wijmenga , Rinse K Weersma , Marijn C Visschedijk

Systematic Prioritization of Candidate Genes in Disease Loci Identifies

Frontiers in genetics

Avec: Adriaan van der Graaf , Maria M Zorro , Annique Claringbould , Urmo Võsa , Raúl Aguirre-Gamboa , Chan Li , Joram Mooiweer , Isis Ricaño-Ponce , Zuzanna Borek , Frits Koning , Yvonne Kooy-Winkelaar , Ludvig M Sollid , Shuo-Wang Qiao , Vinod Kumar , Yang Li , Lude Franke , Sebo Withoff , Cisca Wijmenga , Serena Sanna , Iris Jonkers , Auteur inconnu

Phage display sequencing reveals that genetic, environmental, and intrinsic factors influence variation of human antibody epitope repertoire.

Immunity

Avec: Sergio Andreu-Sánchez , Arno R Bourgonje , Thomas Vogl , Alexander Kurilshikov , Sigal Leviatan , Angel J Ruiz-Moreno , Shixian Hu , Trishla Sinha , Arnau Vich Vila , Shelley Klompus , Iris N Kalka , Karina de Leeuw , Suzanne Arends , Iris Jonkers , Sebo Withoff , Auteur inconnu , Elisabeth Brouwer , Adina Weinberger , Cisca Wijmenga , Eran Segal , Rinse K Weersma , Jingyuan Fu , Alexandra Zhernakova

Standardizing designed and emergent quantitative features in microphysiological systems.

Nature biomedical engineering

Avec: Dennis M Nahon , Renée Moerkens , Hande Aydogmus , Bas Lendemeijer , Adriana Martínez-Silgado , Jeroen M Stein , Milica Dostanić , Jean-Philippe Frimat , Cristina Gontan , Mees N S de Graaf , Michel Hu , Dhanesh G Kasi , Lena S Koch , Kieu T T Le , Sangho Lim , Heleen H T Middelkamp , Joram Mooiweer , Paul Motreuil-Ragot , Eva Niggl , Cayetano Pleguezuelos-Manzano , Jens Puschhof , Nele Revyn , José M Rivera-Arbelaez , Jelle Slager , Laura M Windt , Mariia Zakharova , Berend J van Meer , Valeria V Orlova , Femke M S de Vrij , Sebo Withoff , Massimo Mastrangeli , Andries D van der Meer , Christine L Mummery

Tissue alarmins and adaptive cytokine induce dynamic and distinct transcriptional responses in tissue-resident intraepithelial cytotoxic T lymphocytes.

Journal of autoimmunity

Avec: Maria Magdalena Zorro , Raul Aguirre-Gamboa , Toufic Mayassi , Cezary Ciszewski , Donatella Barisani , Shixian Hu , Rinse K Weersma , Sebo Withoff , Yang Li , Cisca Wijmenga , Bana Jabri , Iris H Jonkers

Celiac disease-on-chip: Modeling a multifactorial disease in vitro.

United European gastroenterology journal

Avec: Renée Moerkens , Joram Mooiweer , Sebo Withoff , Cisca Wijmenga

Intestinal Barrier Function in Gluten-Related Disorders.

Nutrients

Avec: Danielle Cardoso-Silva , Deborah Delbue , Alice Itzlinger , Renée Moerkens , Sebo Withoff , Federica Branchi , Michael Schumann

A Combined mRNA- and miRNA-Sequencing Approach Reveals miRNAs as Potential Regulators of the Small Intestinal Transcriptome in Celiac Disease.

International journal of molecular sciences

Avec: Ineke Luise Tan , Donatella Barisani , Roberto Panceri , Rutger Modderman , Marijn Visschedijk , Rinse K Weersma , Cisca Wijmenga , Iris Jonkers , Rodrigo Coutinho de Almeida , Sebo Withoff

Molecular Biomarkers for Celiac Disease: Past, Present and Future.

International journal of molecular sciences

Avec: Aarón D Ramírez-Sánchez , Ineke L Tan , B C Gonera-de Jong , Marijn C Visschedijk , Iris Jonkers , Sebo Withoff

Integration of metabolomics, genomics, and immune phenotypes reveals the causal roles of metabolites in disease.

Genome biology

Avec: Xiaojing Chu , Martin Jaeger , Joep Beumer , Olivier B Bakker , Raul Aguirre-Gamboa , Marije Oosting , Sanne P Smeekens , Simone Moorlag , Vera P Mourits , Valerie A C M Koeken , Charlotte de Bree , Trees Jansen , Ian T Mathews , Khoi Dao , Mahan Najhawan , Jeramie D Watrous , Irma Joosten , Sonia Sharma , Hans J P M Koenen , Sebo Withoff , Iris H Jonkers , Romana T Netea-Maier , Ramnik J Xavier , Lude Franke , Cheng-Jian Xu , Leo A B Joosten , Serena Sanna , Mohit Jain , Vinod Kumar , Hans Clevers , Cisca Wijmenga , Mihai G Netea , Yang Li

Réseau de co-auteurs

Cisca Wijmenga 20 collaborations

Yang Li 10 collaborations

Vinod Kumar 9 collaborations

Iris H Jonkers 9 collaborations

Iris Jonkers 9 collaborations

Lude Franke 6 collaborations

Rinse K Weersma 6 collaborations

Aarón D Ramírez-Sánchez 5 collaborations

Rutger Modderman 5 collaborations

Leo A B Joosten 5 collaborations

Mihai G Netea 5 collaborations

Renée Moerkens 5 collaborations

Joram Mooiweer 5 collaborations

Martin Jaeger 4 collaborations

Raúl Aguirre-Gamboa 4 collaborations

Serena Sanna 4 collaborations

Jingyuan Fu 4 collaborations

Xiaojing Chu 4 collaborations

Ineke L Tan 4 collaborations

None None 4 collaborations

Olivier B Bakker 3 collaborations

Yvonne Kooy-Winkelaar 3 collaborations

Vasiliki Matzaraki 3 collaborations

Kieu T T Le 3 collaborations

Alexandra Zhernakova 3 collaborations

Donatella Barisani 3 collaborations

Marijn C Visschedijk 3 collaborations

Niek de Klein 2 collaborations

Shuo-Wang Qiao 2 collaborations

Ludvig M Sollid 2 collaborations

Frits Koning 2 collaborations

Melissa D Johnson 2 collaborations

Sibylle Koletzko 2 collaborations

Ilma R Korponay-Szabó 2 collaborations

Riccardo Troncone 2 collaborations

Jelle Slager 2 collaborations

Marije Oosting 2 collaborations

Sanne P Smeekens 2 collaborations

Rodrigo Coutinho de Almeida 2 collaborations

Anna Stachurska 2 collaborations

Roy Oelen 2 collaborations

Annique Claringbould 2 collaborations

Urmo Võsa 2 collaborations

Maria M Zorro 2 collaborations

Zuzanna Borek 2 collaborations

Isis Ricaño-Ponce 2 collaborations

Irma Joosten 2 collaborations

Hans J P M Koenen 2 collaborations

Shixian Hu 2 collaborations

Raul Aguirre-Gamboa 2 collaborations

Zuzanna A Borek 1 collaboration

Marie K Johannesen 1 collaboration

Filomena Matarese 1 collaboration

Joost H A Martens 1 collaboration

Jeroen van Bergen 1 collaboration

Knut E A Lundin 1 collaboration

Diletta Rosati 1 collaboration

Luisa Mearin 1 collaboration

Victoria E J M Palasantzas 1 collaboration

Isabel Tamargo-Rubio 1 collaboration

Kieu Le 1 collaboration

Mark S Gresnigt 1 collaboration

John R Perfect 1 collaboration

Frank L van de Veerdonk 1 collaboration

Bart-Jan Kullberg 1 collaboration

Josée A Plantinga 1 collaboration

Jill Moser 1 collaboration

Jackie Dekens 1 collaboration

Caroline R Meijer 1 collaboration

María Roca 1 collaboration

Eva Martinez-Ojinaga 1 collaboration

Raanan Shamir 1 collaboration

Renata Auricchio 1 collaboration

Gemma Castillejo 1 collaboration

Hania Szajewska 1 collaboration

M Luisa Mearin 1 collaboration

Robert J Barrett 1 collaboration

Biljana Atanasovska 1 collaboration

Sander S Rensen 1 collaboration

Glenn Marsman 1 collaboration

Ronit Shiri-Sverdlov 1 collaboration

Folkert Kuipers 1 collaboration

Bart van de Sluis 1 collaboration

Werna T C Uniken Venema 1 collaboration

Emilia Bigaeva 1 collaboration

Rebecca E McIntyre 1 collaboration

Mennatallah Ghouraba 1 collaboration

Tim Raine 1 collaboration

Eleonora A M Festen 1 collaboration

Monique G P van der Wijst 1 collaboration

Matthew R Lincoln 1 collaboration

Noah Connally 1 collaboration

Pierre-Paul Axisa 1 collaboration

Christiane Gasperi 1 collaboration

Mitja Mitrovic 1 collaboration

David van Heel 1 collaboration

Leonid Padyukov 1 collaboration

Stephen S Rich 1 collaboration

Robert R Graham 1 collaboration

Patrick M Gaffney 1 collaboration

Carl D Langefeld 1 collaboration

Timothy J Vyse 1 collaboration

David A Hafler 1 collaboration

Sung Chun 1 collaboration

Shamil R Sunyaev 1 collaboration

Chris Cotsapas 1 collaboration

Rodrigo Almeida 1 collaboration

Riemer de Vries 1 collaboration

Dorothea J Heersema 1 collaboration

Ranko Gacesa 1 collaboration

Jan F Meilof 1 collaboration

Hanna L Simpson 1 collaboration

Eline Smits 1 collaboration

Jennifer di Tommaso 1 collaboration

Monique Gp van der Wijst 1 collaboration

Dylan de Vries 1 collaboration

Harm Brugge 1 collaboration

Xiaojin Chu 1 collaboration

Patrick Deelen 1 collaboration

Cheng-Jiang Xu 1 collaboration

Morris Swertz 1 collaboration

Jeroen J Kolkman 1 collaboration

Adriaan van der Graaf 1 collaboration

Chan Li 1 collaboration

Sergio Andreu-Sánchez 1 collaboration

Arno R Bourgonje 1 collaboration

Thomas Vogl 1 collaboration

Alexander Kurilshikov 1 collaboration

Sigal Leviatan 1 collaboration

Angel J Ruiz-Moreno 1 collaboration

Trishla Sinha 1 collaboration

Arnau Vich Vila 1 collaboration

Shelley Klompus 1 collaboration

Iris N Kalka 1 collaboration

Karina de Leeuw 1 collaboration

Suzanne Arends 1 collaboration

Elisabeth Brouwer 1 collaboration

Adina Weinberger 1 collaboration

Eran Segal 1 collaboration

Dennis M Nahon 1 collaboration

Hande Aydogmus 1 collaboration

Bas Lendemeijer 1 collaboration

Adriana Martínez-Silgado 1 collaboration

Jeroen M Stein 1 collaboration

Milica Dostanić 1 collaboration

Jean-Philippe Frimat 1 collaboration

Cristina Gontan 1 collaboration

Mees N S de Graaf 1 collaboration

Michel Hu 1 collaboration

Dhanesh G Kasi 1 collaboration

Lena S Koch 1 collaboration

Sangho Lim 1 collaboration

Heleen H T Middelkamp 1 collaboration

Paul Motreuil-Ragot 1 collaboration

Eva Niggl 1 collaboration

Cayetano Pleguezuelos-Manzano 1 collaboration

Jens Puschhof 1 collaboration

Nele Revyn 1 collaboration

José M Rivera-Arbelaez 1 collaboration

Laura M Windt 1 collaboration

Mariia Zakharova 1 collaboration

Berend J van Meer 1 collaboration

Valeria V Orlova 1 collaboration

Femke M S de Vrij 1 collaboration

Massimo Mastrangeli 1 collaboration

Andries D van der Meer 1 collaboration

Christine L Mummery 1 collaboration

Maria Magdalena Zorro 1 collaboration

Toufic Mayassi 1 collaboration

Cezary Ciszewski 1 collaboration

Bana Jabri 1 collaboration

Danielle Cardoso-Silva 1 collaboration

Deborah Delbue 1 collaboration

Alice Itzlinger 1 collaboration

Federica Branchi 1 collaboration

Michael Schumann 1 collaboration

Ineke Luise Tan 1 collaboration

Roberto Panceri 1 collaboration

Marijn Visschedijk 1 collaboration

B C Gonera-de Jong 1 collaboration

Joep Beumer 1 collaboration

Simone Moorlag 1 collaboration

Vera P Mourits 1 collaboration

Valerie A C M Koeken 1 collaboration

Charlotte de Bree 1 collaboration

Trees Jansen 1 collaboration

Ian T Mathews 1 collaboration

Khoi Dao 1 collaboration

Mahan Najhawan 1 collaboration

Jeramie D Watrous 1 collaboration

Sonia Sharma 1 collaboration

Romana T Netea-Maier 1 collaboration

Ramnik J Xavier 1 collaboration

Cheng-Jian Xu 1 collaboration

Mohit Jain 1 collaboration

Hans Clevers 1 collaboration