Systematic Prioritization of Candidate Genes in Disease Loci Identifies
TRAFD1
celiac disease
expression quantitative trait locus (eQTL)
gene prioritization
trans regulation
Journal
Frontiers in genetics
ISSN: 1664-8021
Titre abrégé: Front Genet
Pays: Switzerland
ID NLM: 101560621
Informations de publication
Date de publication:
2020
2020
Historique:
received:
10
07
2020
accepted:
16
12
2020
entrez:
11
2
2021
pubmed:
12
2
2021
medline:
12
2
2021
Statut:
epublish
Résumé
Celiac disease (CeD) is a complex T cell-mediated enteropathy induced by gluten. Although genome-wide association studies have identified numerous genomic regions associated with CeD, it is difficult to accurately pinpoint which genes in these loci are most likely to cause CeD. We used four different
Identifiants
pubmed: 33569077
doi: 10.3389/fgene.2020.562434
pmc: PMC7868554
doi:
Types de publication
Journal Article
Langues
eng
Pagination
562434Informations de copyright
Copyright © 2021 van der Graaf, Zorro, Claringbould, Võsa, Aguirre-Gamboa, Li, Mooiweer, Ricaño-Ponce, Borek, Koning, Kooy-Winkelaar, Sollid, Qiao, Kumar, Li, Franke, Withoff, Wijmenga, Sanna, Jonkers and BIOS Consortium.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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