iPSC-derived organ-on-a-chip models for personalized human genetics and pharmacogenomics studies.

Humans Induced Pluripotent Stem Cells Microphysiological Systems Pharmacogenetics Genome-Wide Association Study Human Genetics
iPSCs intestine-on-a-chip liver-on-a-chip organ-on-a-chip personalized medicine pharmacogenomics vessel-on-a-chip

Journal

Trends in genetics : TIG
ISSN: 0168-9525
Titre abrégé: Trends Genet
Pays: England
ID NLM: 8507085

Informations de publication

Date de publication:
04 2023
Historique:
received: 13 07 2022
revised: 24 11 2022
accepted: 12 01 2023
pubmed: 7 2 2023
medline: 24 3 2023
entrez: 6 2 2023
Statut: ppublish

Résumé

Genome-wide association studies (GWAS) have now correlated hundreds of genetic variants with complex genetic diseases and drug efficacy. Functional characterization of these factors remains challenging, particularly because of the lack of human model systems. Molecular and nanotechnological advances, in particular the ability to generate patient-specific PSC lines, differentiate them into diverse cell types, and seed and combine them on microfluidic chips, have led to the establishment of organ-on-a-chip (OoC) platforms that recapitulate organ biology. OoC technology thus provides unique personalized platforms for studying the effects of host genetics and environmental factors on organ physiology. In this review we describe the technology and provide examples of how OoCs may be used for disease modeling and pharmacogenetic research.

Identifiants

DOI: 10.1016/j.tig.2023.01.002 PMID: 36746737
pubmed: 36746737
pii: S0168-9525(23)00017-3
doi: 10.1016/j.tig.2023.01.002
pii:
doi:

Types de publication

Journal Article Review Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

268-284

Informations de copyright

Copyright © 2023. Published by Elsevier Ltd.

Déclaration de conflit d'intérêts

Declaration of interests No interests are declared.

Auteurs

Victoria E J M Palasantzas (VEJM)

Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands; Department of Pediatrics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

Isabel Tamargo-Rubio (I)

Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

Kieu Le (K)

Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

Jelle Slager (J)

Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

Cisca Wijmenga (C)

Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

Iris H Jonkers (IH)

Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

Vinod Kumar (V)

Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands; Department of Internal Medicine and Radboud Centre for Infectious Diseases, Radboud University Medical Center, Nijmegen, The Netherlands.

Jingyuan Fu (J)

Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands; Department of Pediatrics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

Sebo Withoff (S)

Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. Electronic address: s.withoff@umcg.nl.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › iPSC-derived organ-on-a-chip models for...
questionsmedicales.fr › Cellules › Cellules souches › Cellules souches pluripotentes › Cellules souches pluripotentes induites › iPSC-derived organ-on-a-chip models for...
questionsmedicales.fr › Équipement et fournitures › Équipement et fournitures électriques › Laboratoires sur puces › Systèmes microphysiologiques › iPSC-derived organ-on-a-chip models for...
questionsmedicales.fr › Professions de santé › Pharmacologie › Pharmacogénétique › iPSC-derived organ-on-a-chip models for...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Épidémiologie moléculaire › Étude d'association pangénomique › iPSC-derived organ-on-a-chip models for...
questionsmedicales.fr › Disciplines des sciences naturelles › Disciplines des sciences biologiques › Biologie › Génétique › Génétique humaine › iPSC-derived organ-on-a-chip models for...