Impact of genetic polymorphisms in kinetochore and spindle assembly genes on chromosomal aberration frequency in healthy humans.
Adult
Cells, Cultured
Chromosomal Proteins, Non-Histone
/ genetics
Chromosome Aberrations
Cohort Studies
Cyclin B1
/ genetics
Cyclin-Dependent Kinases
/ genetics
Female
Gene Frequency
Humans
Kinetochores
/ metabolism
Linear Models
M Phase Cell Cycle Checkpoints
/ genetics
Male
Odds Ratio
Polymorphism, Single Nucleotide
Transcription Factors
/ genetics
Cyclin-Dependent Kinase-Activating Kinase
Chromosomal aberration
Environmental toxicology
GWAS
Genetic Polymorphism
Kinetochore Function
Mitotic checkpoint
Journal
Mutation research. Genetic toxicology and environmental mutagenesis
ISSN: 1879-3592
Titre abrégé: Mutat Res Genet Toxicol Environ Mutagen
Pays: Netherlands
ID NLM: 101632149
Informations de publication
Date de publication:
Historique:
received:
17
06
2020
revised:
24
08
2020
accepted:
10
09
2020
entrez:
17
11
2020
pubmed:
18
11
2020
medline:
2
3
2021
Statut:
ppublish
Résumé
Genomic instability is a characteristic of a majority of human malignancies. Chromosomal instability is a common form of genomic instability that can be caused by defects in mitotic checkpoint genes. Chromosomal aberrations in peripheral blood are also indicative of genotoxic exposure and potential cancer risk. We evaluated associations between inherited genetic variants in 33 mitotic checkpoint genes and the frequency of chromosomal aberrations (CAs) in the presence and absence of environmental genotoxic exposure. Associations with both chromosome and chromatid type of aberrations were evaluated in two cohorts of healthy individuals, namely an exposed and a reference group consisting of 607 and 866 individuals, respectively. Binary logistic and linear regression analyses were performed for the association studies. Bonferroni-corrected significant p-value was 5 × 10
Identifiants
pubmed: 33198934
pii: S1383-5718(20)30123-6
doi: 10.1016/j.mrgentox.2020.503253
pii:
doi:
Substances chimiques
CCNB1 protein, human
0
CENPH protein, human
0
Chromosomal Proteins, Non-Histone
0
Cyclin B1
0
TEX14 protein, human
0
Transcription Factors
0
Cyclin-Dependent Kinases
EC 2.7.11.22
Cyclin-Dependent Kinase-Activating Kinase
EC 2.7.11.22
Types de publication
Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
503253Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.