Raynaud's phenomenon.
Raynaud's phenomenon
digital ulcers
systemic sclerosis
Journal
Clinical medicine (London, England)
ISSN: 1473-4893
Titre abrégé: Clin Med (Lond)
Pays: England
ID NLM: 101092853
Informations de publication
Date de publication:
11 2020
11 2020
Historique:
entrez:
17
11
2020
pubmed:
18
11
2020
medline:
13
5
2021
Statut:
ppublish
Résumé
Raynaud's phenomenon (RP) is a common vasospastic condition which affects ~5% of the general population. The majority of individuals have primary RP; however, Raynaud's can also occur secondary to a broad range of underlying medical conditions and drug therapies. RP is a cardinal feature in patients with systemic sclerosis and is often the earliest symptom of the disease. Unlike primary RP, patients with secondary RP can develop persistent digital ischaemia, including ulcers and gangrene. Patients require a comprehensive clinical assessment and investigation, in particular, the detection of autoantibodies and nailfold capillaroscopic abnormalities. Non-pharmacological management is indicated in all patients. There are a wide range of available drug therapies to treat RP, including when complicated by digital ulceration, and surgical intervention is sometimes required. Future research is needed to understand the complex pathogenesis of RP and to measure the impact and severity of RP to develop optimised approaches to management.
Identifiants
pubmed: 33199324
pii: 20/6/580
doi: 10.7861/clinmed.2020-0754
pmc: PMC7687329
doi:
Substances chimiques
Autoantibodies
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
580-587Informations de copyright
© Royal College of Physicians 2020. All rights reserved.
Références
J Am Acad Dermatol. 2011 Sep;65(3):e102-e104
pubmed: 21839301
Pharmaceutics. 2019 Nov 09;11(11):
pubmed: 31717566
PLoS One. 2018 Apr 26;13(4):e0196279
pubmed: 29698501
J Rheumatol. 2010 Apr;37(4):783-6
pubmed: 20194444
J Scleroderma Relat Disord. 2018 Oct;3(3):249-252
pubmed: 30705970
Rheumatology (Oxford). 2015 Aug;54(8):1443-7
pubmed: 25752312
J Mal Vasc. 2006 Feb;31(1):10-5
pubmed: 16609626
Arthritis Rheum. 1973 Sep-Oct;16(5):619-28
pubmed: 4742842
Rheumatology (Oxford). 2011 Apr;50(4):762-7
pubmed: 21149249
Rheumatol Int. 2011 Nov;31(11):1409-17
pubmed: 21800117
Clin Exp Rheumatol. 1992 Sep-Oct;10(5):485-8
pubmed: 1458701
Arthritis Rheumatol. 2018 Jun;70(6):903-911
pubmed: 29457381
Clin Rheumatol. 2020 Sep;39(9):2823-2824
pubmed: 32385759
Circulation. 1995 Sep 15;92(6):1448-51
pubmed: 7664425
Arthritis Rheum. 2008 Dec;58(12):3902-12
pubmed: 19035499
Rheumatology (Oxford). 2005 May;44(5):587-96
pubmed: 15741200
Pol Arch Intern Med. 2019 Nov 29;129(11):798-808
pubmed: 31577265
J Rheumatol. 1988 Feb;15(2):202-5
pubmed: 3361530
Br J Hosp Med (Lond). 2019 Nov 2;80(11):658-664
pubmed: 31707892
Rheumatology (Oxford). 2015 Nov;54(11):2015-24
pubmed: 26116156
Arthritis Care Res (Hoboken). 2020 May;72(5):723-733
pubmed: 31841265
Arthritis Care Res (Hoboken). 2018 Sep;70(9):1373-1384
pubmed: 29473715
Ann Rheum Dis. 2019 Mar;78(3):439-441
pubmed: 30309971
Circ Res. 2004 May 28;94(10):1367-74
pubmed: 15087420
Ann Pharmacother. 2016 Dec;50(12):1060-1067
pubmed: 27465880
Semin Arthritis Rheum. 2020 Oct;50(5):1114-1130
pubmed: 32920325
J Am Acad Dermatol. 2018 Jun;78(6):1110-1118.e3
pubmed: 29408338
Ann Plast Surg. 2015 Dec;75(6):637-43
pubmed: 26418780
Arthritis Rheumatol. 2018 Nov;70(11):1820-1828
pubmed: 29781586
Vasa. 2017 Oct;46(6):413-423
pubmed: 28895508
Clin Rheumatol. 2019 Dec;38(12):3669-3676
pubmed: 31482318
Curr Treatm Opt Rheumatol. 2018 Sep;4(3):235-254
pubmed: 31538045
Nat Rev Rheumatol. 2020 Apr;16(4):208-221
pubmed: 32099191
Autoimmun Rev. 2020 Mar;19(3):102458
pubmed: 31927087
Arthritis Rheumatol. 2016 Oct;68(10):2527-39
pubmed: 27111549
Adv Clin Exp Med. 2018 Nov;27(11):1587-1592
pubmed: 29558039
Eur J Rheumatol. 2020 Jun 08;:
pubmed: 32525479
Blood Coagul Fibrinolysis. 2007 Jun;18(4):297-302
pubmed: 17473568
Br J Rheumatol. 1997 Oct;36(10):1045-50
pubmed: 9374919
JAMA. 2016 May 10;315(18):1975-88
pubmed: 27163986
J Autoimmun. 2014 Feb-Mar;48-49:60-5
pubmed: 24491823
Microvasc Res. 2017 May;111:32-36
pubmed: 28027937
Autoimmun Rev. 2019 Nov;18(11):102394
pubmed: 31520797
BMJ Open. 2015 Mar 16;5(3):e006389
pubmed: 25776043
Clin Rheumatol. 2019 Dec;38(12):3317-3330
pubmed: 31420815
J Psychosom Res. 2019 Jan;116:6-9
pubmed: 30654995
Rev Assoc Med Bras (1992). 2019 Nov 07;65(10):1314-1320
pubmed: 31721965
Clin Exp Med. 2019 Aug;19(3):357-366
pubmed: 30989453
Ann Rheum Dis. 2012 Aug;71(8):1355-60
pubmed: 22615460
Rheumatology (Oxford). 2020 Mar 1;59(3):464-466
pubmed: 31670800
Rheumatology (Oxford). 2015 Aug;54(8):1435-42
pubmed: 25749623
Clin Rheumatol. 2020 Aug;39(8):2363-2367
pubmed: 32152916
Nat Rev Rheumatol. 2012 Aug;8(8):469-79
pubmed: 22782008
Semin Arthritis Rheum. 2016 Oct;46(2):209-216
pubmed: 27318627
Arthritis Rheumatol. 2017 Aug;69(8):1661-1669
pubmed: 28426903
Lancet. 1990 Dec 22-29;336(8730):1530-3
pubmed: 1979366
J Rheumatol. 2013 Dec;40(12):2023-8
pubmed: 24128778
Rheumatology (Oxford). 2016 Oct;55(10):1906-10
pubmed: 27284161
Clin Rheumatol. 2007 Aug;26(8):1268-74
pubmed: 17160528
Circulation. 1988 May;77(5):988-96
pubmed: 3359596
BMJ. 2018 Mar 14;360:j5492
pubmed: 29540357
Ann Rheum Dis. 2016 Jun;75(6):1009-15
pubmed: 25995322
Ann Rheum Dis. 2011 Jan;70(1):32-8
pubmed: 20805294
Best Pract Res Clin Rheumatol. 2020 Feb;34(1):101474
pubmed: 32007400
Rheumatology (Oxford). 2007 Mar;46(3):533-8
pubmed: 17018538