COVID-19 outcomes in UK centre within highest health and wealth band: a prospective cohort study.


Journal

BMJ open
ISSN: 2044-6055
Titre abrégé: BMJ Open
Pays: England
ID NLM: 101552874

Informations de publication

Date de publication:
16 11 2020
Historique:
entrez: 17 11 2020
pubmed: 18 11 2020
medline: 15 12 2020
Statut: epublish

Résumé

To describe the characteristics and outcomes of hospitalised patients with COVID-19 from UK in the highest decile of health and gross regional products per capita. Prospective cohort study. Recruited all adult inpatients with laboratory-confirmed COVID-19 symptoms admitted to a single Surrey centre between March and April 2020. Extensive demographic details were documented. COVID-19 status of alive/dead and intensive care unit (ICU) status of yes/no. Patients with COVID-19 from Surrey centre UK (n=429). 429 adult inpatients (mean age 70±18 years; men 56.4%) were included in this study, of whom, 19.1% required admission to ICU and 31.9% died. Adverse outcomes were associated with age (OR with each decade of years: 1.78, 95% CI 1.53 to 2.11, p<0.001 for mortality); male gender (OR=1.08, 95% CI 0.72 to 1.63, p=0.72, present in 70.7%, of admissions to ICU versus 53% of other cases, p=0.004); cardiac disease (OR=3.43, 95% CI 2.10 to 5.63, p<0.001), diabetes mellitus (OR=2.37, 95% CI 1.09 to 5.17, p=0.028) and dementia (OR=5.06, 95% CI 2.79 to 9.44, p<0.001). There was no significant impact of ethnicity or body mass index on disease outcome. Despite reports of worse outcomes in deprived regions, we show similar complication and mortality rates due to COVID-19 in an affluent and high life expectancy region.

Identifiants

pubmed: 33199428
pii: bmjopen-2020-042090
doi: 10.1136/bmjopen-2020-042090
pmc: PMC7670555
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

e042090

Informations de copyright

© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

Déclaration de conflit d'intérêts

Competing interests: None declared.

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Auteurs

Gie Ken-Dror (G)

Institute of Cardiovascular Research, Royal Holloway University of London, Egham, UK.

Charles Wade (C)

Department of Clinical Neuroscience, Imperial College Healthcare NHS Trust, London, UK.

Shyam Sharma (S)

College of Medicine, University of Edinburgh, Edinburgh, Scotland.

Jessica Law (J)

Division of Medicine, Ashford and Saint Peter's Hospitals NHS Foundation Trust, Chertsey, Surrey, UK.

Cristina Russo (C)

Division of Medicine, Ashford and Saint Peter's Hospitals NHS Foundation Trust, Chertsey, Surrey, UK.

Aarti Sharma (A)

School of Medicine, Imperial College London, London, UK.

Elizabeth Joy (E)

Division of Medicine, Ashford and Saint Peter's Hospitals NHS Foundation Trust, Chertsey, Surrey, UK.

Joshua John (J)

School of Medicine, Kings College London, London, UK.

Jonathan Robin (J)

Division of Medicine, Ashford and Saint Peter's Hospitals NHS Foundation Trust, Chertsey, Surrey, UK.

Sarah John (S)

Murray Edwards College, University of Cambridge, Cambridge, UK.

Karim Mahana (K)

Division of Medicine, Ashford and Saint Peter's Hospitals NHS Foundation Trust, Chertsey, Surrey, UK.

David Fluck (D)

Division of Medicine, Ashford and Saint Peter's Hospitals NHS Foundation Trust, Chertsey, Surrey, UK.

Paul Bentley (P)

Department of Brain Sciences, Imperial College London, London, UK.

Pankaj Sharma (P)

Institute of Cardiovascular Research, Royal Holloway University of London, Egham, UK pankaj.sharma@rhul.ac.uk.
Department of Clinical Neuroscience, Imperial College Healthcare NHS Trust, London, UK.

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