Relationship between cell number and clinical outcomes of autologous bone-marrow mononuclear cell implantation in critical limb ischemia.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
16 11 2020
16 11 2020
Historique:
received:
08
07
2020
accepted:
23
09
2020
entrez:
17
11
2020
pubmed:
18
11
2020
medline:
12
3
2021
Statut:
epublish
Résumé
Cell therapy using intramuscular injections of autologous bone-marrow mononuclear cells (BM-MNCs) improves clinical symptoms and can prevent limb amputation in atherosclerotic peripheral arterial disease (PAD) patients with critical limb ischemia (CLI). The purpose of this study was to evaluate the effects of the number of implanted BM-MNCs on clinical outcomes in atherosclerotic PAD patients with CLI who underwent cell therapy. This study was a retrospective observational study with median follow-up period of 13.5 years (range, 6.8-15.5 years) from BM-MNC implantation procedure. The mean number of implanted cells was 1.2 ± 0.7 × 10
Identifiants
pubmed: 33199760
doi: 10.1038/s41598-020-76886-6
pii: 10.1038/s41598-020-76886-6
pmc: PMC7669841
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
19891Références
Eur J Vasc Endovasc Surg. 2007;33 Suppl 1:S1-75
pubmed: 17140820
Helv Chir Acta. 1954 Dec;21(5-6):499-533
pubmed: 14366554
Stem Cells. 2018 Feb;36(2):161-171
pubmed: 29226477
Circ J. 2018 Mar 23;82(4):1168-1178
pubmed: 29386474
Cochrane Database Syst Rev. 2018 Aug 29;8:CD010747
pubmed: 30155883
Lancet. 2002 Aug 10;360(9331):427-35
pubmed: 12241713
Sci Rep. 2017 Jul 21;7(1):6095
pubmed: 28733607
J Vasc Surg. 2016 Jun;63(6):1541-5
pubmed: 27021379
Sci Rep. 2019 May 22;9(1):7711
pubmed: 31118440
J Vasc Surg. 2014 Jan;59(1):220-34.e1-2
pubmed: 24126108
Am Heart J. 2008 Nov;156(5):1010-8
pubmed: 19061721
J Vasc Surg. 2009 Dec;50(6):1378-90
pubmed: 19837539
J Vasc Surg. 1997 Sep;26(3):517-38
pubmed: 9308598
Lancet. 2013 Oct 19;382(9901):1329-40
pubmed: 23915883
Circ J. 2017 Oct 25;81(11):1713-1720
pubmed: 28603176
Circ Cardiovasc Interv. 2011 Feb 1;4(1):15-25
pubmed: 21205941
Atherosclerosis. 2010 Mar;209(1):10-7
pubmed: 19740466
J Am Heart Assoc. 2016 Feb 23;5(2):
pubmed: 26908409
Circ Res. 2017 Apr 14;120(8):1326-1340
pubmed: 28096194