Deletion of the transcription factor Prox-1 specifically in the renal distal convoluted tubule causes hypomagnesemia via reduced expression of TRPM6 and NCC.
Animals
Aquaporin 2
/ genetics
Gene Deletion
Gene Expression Regulation
/ physiology
Homeodomain Proteins
/ genetics
Kidney Tubules, Distal
/ cytology
Magnesium
/ metabolism
Mice
Potassium
/ metabolism
Sodium
/ metabolism
Solute Carrier Family 12, Member 1
/ genetics
Solute Carrier Family 12, Member 3
/ genetics
TRPM Cation Channels
/ genetics
Tumor Suppressor Proteins
/ genetics
DCT adaptation
Kidney
NaCl cotransporter (NCC)
Renal distal convoluted tubule (DCT)
Transcription factor Prox-1
Transient receptor potential cation channel subfamily M member 6 (TRPM6)
Journal
Pflugers Archiv : European journal of physiology
ISSN: 1432-2013
Titre abrégé: Pflugers Arch
Pays: Germany
ID NLM: 0154720
Informations de publication
Date de publication:
01 2021
01 2021
Historique:
received:
14
08
2020
accepted:
05
11
2020
revised:
25
10
2020
pubmed:
18
11
2020
medline:
15
12
2021
entrez:
17
11
2020
Statut:
ppublish
Résumé
The renal distal convoluted tubule (DCT) is critical for the fine-tuning of urinary ion excretion and the control of blood pressure. Ion transport along the DCT is tightly controlled by posttranscriptional mechanisms including a complex interplay of kinases, phosphatases, and ubiquitin ligases. Previous work identified the transcription factor Prox-1 as a gene significantly enriched in the DCT of adult mice. To test if Prox-1 contributes to the transcriptional regulation of DCT function and structure, we developed a novel mouse model (NCC
Identifiants
pubmed: 33200256
doi: 10.1007/s00424-020-02491-1
pii: 10.1007/s00424-020-02491-1
pmc: PMC7782375
doi:
Substances chimiques
Aqp2 protein, mouse
0
Aquaporin 2
0
Homeodomain Proteins
0
Slc12a1 protein, mouse
0
Slc12a3 protein, mouse
0
Solute Carrier Family 12, Member 1
0
Solute Carrier Family 12, Member 3
0
TRPM Cation Channels
0
Trpm6 protein, mouse
0
Tumor Suppressor Proteins
0
prospero-related homeobox 1 protein
0
Sodium
9NEZ333N27
Magnesium
I38ZP9992A
Potassium
RWP5GA015D
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
79-93Subventions
Organisme : Swiss National Science Foundation
ID : 310030_173276/1
Pays : Switzerland
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