Quantitative magnetization transfer imaging for non-contrast enhanced detection of myocardial fibrosis.
cardiac
fibrosis
gadolinium-free
magnetization transfer
quantitative mapping
Journal
Magnetic resonance in medicine
ISSN: 1522-2594
Titre abrégé: Magn Reson Med
Pays: United States
ID NLM: 8505245
Informations de publication
Date de publication:
04 2021
04 2021
Historique:
received:
06
02
2020
revised:
10
09
2020
accepted:
09
10
2020
pubmed:
18
11
2020
medline:
15
5
2021
entrez:
17
11
2020
Statut:
ppublish
Résumé
To develop a novel gadolinium-free model-based quantitative magnetization transfer (qMT) technique to assess macromolecular changes associated with myocardial fibrosis. The proposed sequence consists of a two-dimensional breath-held dual shot interleaved acquisition of five MT-weighted (MTw) spoiled gradient echo images, with variable MT flip angles (FAs) and off-resonance frequencies. A two-pool exchange model and dictionary matching were used to quantify the pool size ratio (PSR) and bound pool T2 relaxation ( PSR values in the BSA phantom were within the confidence interval of previously reported values (concentration 10% BSA = 5.9 ± 0.1%, 15% BSA = 9.4 ± 0.2%). PSR and In vivo model-based qMT mapping of the heart was performed for the first time, with promising results for non-contrast enhanced assessment of myocardial fibrosis.
Substances chimiques
Contrast Media
0
Gadolinium
AU0V1LM3JT
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2069-2083Subventions
Organisme : Medical Research Council
ID : MR/L009676/1
Pays : United Kingdom
Organisme : Department of Health
Pays : United Kingdom
Organisme : Wellcome Trust
ID : WT 203148/Z/16/Z
Pays : United Kingdom
Informations de copyright
© 2020 The Authors. Magnetic Resonance in Medicine published by Wiley Periodicals LLC on behalf of International Society for Magnetic Resonance in Medicine.
Références
Flett AS, Hasleton J, Cook C, et al. Evaluation of techniques for the quantification of myocardial scar of differing etiology using cardiac magnetic resonance. JACC Cardiovasc Imaging. 2011;4:150-156.
Mewton N, Liu CY, Croisille P, Bluemke D, Lima JA. Assessment of myocardial fibrosis with cardiovascular magnetic resonance. J Am Coll Cardiol. 2011;57:891-903.
Kellman P, Wilson JR, Xue H, Ugander M, Arai AE. Extracellular volume fraction mapping in the myocardium, part 1: Evaluation of an automated method. J Cardiovasc Magn Reson. 2012;14:63.
Bull S, White SK, Piechnik SK, et al. Human non-contrast T1 values and correlation with histology in diffuse fibrosis. Heart. 2013;99:932-937.
van Oorschot JW, Gho JM, van Hout GP, et al. Endogenous contrast MRI of cardiac fibrosis: Beyond late gadolinium enhancement. J Magn Reson Imaging. 2015;41:1181-1189.
Kuo PH, Kanal E, Abu-Alfa AK, Cowper SE. Gadolinium-based MR contrast agents and nephrogenic systemic fibrosis. Radiology. 2007;242:647-649.
Robert P, Fingerhut S, Factor C, et al. One-year retention of gadolinium in the brain: Comparison of gadodiamide and gadoterate meglumine in a rodent model. Radiology. 2018;288:424-433.
Phinikaridou A, Andia ME, Saha P, Modarai B, Smith A, Botnar RM. In vivo magnetization transfer and diffusion-weighted magnetic resonance imaging detects thrombus composition in a mouse model of deep vein thrombosis. Circ Cardiovasc Imaging. 2013;6:433-440.
Crooijmans HJ, Ruder TD, Zech WD, et al. Cardiovascular magnetization transfer ratio imaging compared with histology: A postmortem study. J Magn Reson Imaging. 2014;40:915-919.
Wolff SD, Balaban RS. Magnetization transfer contrast (MTC) and tissue water proton relaxation in vivo. Magn Reson Med. 1989;10:135-144.
Stromp TA, Leung SW, Andres KN, et al. Gadolinium free cardiovascular magnetic resonance with 2-point Cine balanced steady state free precession. J Cardiovasc Magn Reson. 2015;17:90.
Weber OM, Speier P, Scheffler K, Bieri O. Assessment of magnetization transfer effects in myocardial tissue using balanced steady-state free precession (bSSFP) cine MRI. Magn Reson Med. 2009;62:699-705.
Duan C, Zhu Y, Jang J, et al. Non-contrast myocardial infarct scar assessment using a hybrid native T1 and magnetization transfer imaging sequence at 1.5T. Magn Reson Med. 2019;81:3192-3201.
Vavasour IM, Laule C, Li DK, Traboulsee AL, MacKay AL. Is the magnetization transfer ratio a marker for myelin in multiple sclerosis? J Magn Reson Imaging. 2011;33:713-718.
Sled JG, Pike GB. Quantitative imaging of magnetization transfer exchange and relaxation properties in vivo using MRI. Magn Reson Med. 2001;46:923-931.
Henkelman RM, Huang X, Xiang QS, Stanisz GJ, Swanson SD, Bronskill MJ. Quantitative interpretation of magnetization transfer. Magn Reson Med. 1993;29:759-766.
Malik SJ, Teixeira R, Hajnal JV. Extended phase graph formalism for systems with magnetization transfer and exchange. Magn Reson Med. 2018;80:767-779.
Weigel M. Extended phase graphs: dephasing, RF pulses, and echoes - Pure and simple. J Magn Reson Imaging. 2015;41:266-295.
Graham SJ, Henkelman RM. Understanding pulsed magnetization transfer. J Magn Reson Imaging. 1997;7:903-912.
Morrison C, Stanisz G, Henkelman RM. Modeling magnetization transfer for biological-like systems using a semi-solid pool with a super-Lorentzian lineshape and dipolar reservoir. J Magn Reson B. 1995;108:103-113.
Ramani A, Dalton C, Miller DH, Tofts PS, Barker GJ. Precise estimate of fundamental in-vivo MT parameters in human brain in clinically feasible times. Magn Reson Imaging. 2002;20:721-731.
Griswold MA, Jakob PM, Heidemann RM, et al. Generalized autocalibrating partially parallel acquisitions (GRAPPA). Magn Reson Med. 2002;47:1202-1210.
Bustin A, Lima da Cruz G, Jaubert O, Lopez K, Botnar RM, Prieto C. High-dimensionality undersampled patch-based reconstruction (HD-PROST) for accelerated multi-contrast MRI. Magn Reson Med. 2019;81:3705-3719.
Modat M, Ridgway GR, Taylor ZA, et al. Fast free-form deformation using graphics processing units. Comput Methods Programs Biomed. 2010;98:278-284.
Koenig SH, Brown RD 3rd, Ugolini R. Magnetization transfer in cross-linked bovine serum albumin solutions at 200 MHz: A model for tissue. Magn Reson Med. 1993;29:311-316.
Lopez K, Neji R, Mukherjee RK, et al. Contrast-free high-resolution 3D magnetization transfer imaging for simultaneous myocardial scar and cardiac vein visualization. MAGMA. 2020;33:627-640.
Giri S, Chung YC, Merchant A, et al. T2 quantification for improved detection of myocardial edema. J Cardiovasc Magn Reson. 2009;11:56.
Huang TY, Liu YJ, Stemmer A, Poncelet BP. T2 measurement of the human myocardium using a T2-prepared transient-state TrueFISP sequence. Magn Reson Med. 2007;57:960-966.
Dabir D, Child N, Kalra A, et al. Reference values for healthy human myocardium using a T1 mapping methodology: Results from the International T1 Multicenter cardiovascular magnetic resonance study. J Cardiovasc Magn Reson. 2014;16:69.
Cerqueira MD, Weissman NJ, Dilsizian V, et al. American heart association writing group on myocardial S, registration for cardiac I. Standardized myocardial segmentation and nomenclature for tomographic imaging of the heart. A statement for healthcare professionals from the cardiac imaging committee of the council on clinical cardiology of the American heart association. Circulation. 2002;105:539-542.
Dortch RD, Li K, Gochberg DF, et al. Quantitative magnetization transfer imaging in human brain at 3 T via selective inversion recovery. Magn Reson Med. 2011;66:1346-1352.
Gochberg DF, Gore JC. Quantitative magnetization transfer imaging via selective inversion recovery with short repetition times. Magn Reson Med. 2007;57:437-441.
Li K, Dortch RD, Kroop SF, et al. A rapid approach for quantitative magnetization transfer imaging in thigh muscles using the pulsed saturation method. Magn Reson Imaging. 2015;33:709-717.
Sinclair CD, Samson RS, Thomas DL, et al. Quantitative magnetization transfer in in vivo healthy human skeletal muscle at 3 T. Magn Reson Med. 2010;64:1739-1748.
Scholz TD, Hoyt RF, DeLeonardis JR, Ceckler TL, Balaban RS. Water-macromolecular proton magnetization transfer in infarcted myocardium: A method to enhance magnetic resonance image contrast. Magn Reson Med. 1995;33:178-184.
Stromp TA, Spear TJ, Holtkamp RM, et al. Quantitative gadolinium-free cardiac fibrosis imaging in end stage renal disease patients reveals a longitudinal correlation with structural and functional decline. Sci Rep. 2018;8:16972.
Ward K, Schussheim AE, Balaban RS. Contribution of mitochondria to cardiac muscle water/macromolecule proton magnetization transfer. Magn Reson Med. 2003;50:1312-1316.
Witschey WR, Zsido GA, Koomalsingh K, et al. In vivo chronic myocardial infarction characterization by spin locked cardiovascular magnetic resonance. J Cardiovasc Magn Reson. 2012;14:37.
van Oorschot JW, Guclu F, de Jong S, et al. Endogenous assessment of diffuse myocardial fibrosis in patients with T1rho -mapping. J Magn Reson Imaging. 2017;45:132-138.
Chow K, Paterson I, Thompson R. Radiofrequency (B1) field mapping in the heart and lungs using a HASTE double angle method. Proc Intl Soc Mag Reson Med. 2008;16:1244.
Kennan RP, Richardson KA, Zhong J, Maryanski MJ, Gore JC. The effects of cross-link density and chemical exchange on magnetization transfer in polyacrylamide gels. J Magn Reson B. 1996;110:267-277.