Beyond diagnosis: Cross-diagnostic features in canonical resting-state networks in children with neurodevelopmental disorders.
ADHD
Autism
Neurodevelopmental disorder
OCD
Resting-state functional connectivity
Journal
NeuroImage. Clinical
ISSN: 2213-1582
Titre abrégé: Neuroimage Clin
Pays: Netherlands
ID NLM: 101597070
Informations de publication
Date de publication:
2020
2020
Historique:
received:
27
02
2020
revised:
15
10
2020
accepted:
17
10
2020
pubmed:
18
11
2020
medline:
29
6
2021
entrez:
17
11
2020
Statut:
ppublish
Résumé
Children with neurodevelopmental disorders (NDDs) share common behavioural manifestations despite distinct categorical diagnostic criteria. Here, we examined canonical resting-state network connectivity in three diagnostic groups (autism spectrum disorder, attention-deficit/hyperactivity disorder and paediatric obsessive-compulsive disorder) and typically developing controls (TD) in a large single-site sample (N = 407), applying diagnosis-based and dimensional approaches to understand underlying neurobiology across NDDs. Each participant's functional network graphs were computed using five graph metrics. In diagnosis-based comparisons, an analysis of covariance was performed to compare all NDDs to TD, followed by pairwise comparisons between NDDs. In the dimensional approach, participants' functional network graphs were correlated with continuous behavioural measures, and a data-driven k-means clustering analysis was applied to determine if subgroups of participants were seen, without diagnostic information having been included. In the diagnosis-based comparisons, children with NDDs did not differ significantly from the TD group and the NDD categorical groups also did not differ significantly from each other, across all graph metrics. In the dimensional, diagnostic-independent approach, however, subcortical functional connectivity was significantly correlated with participants' general adaptive functioning across all participants. The clustering analysis identified an optimal solution of two clusters, and participants assigned in the same data-driven cluster were highly heterogeneous in diagnosis. Neither cluster exclusively contained a specific diagnostic group, nor did NDDs separate cleanly from TDs. Each participant's distance ratio between the two clusters was significantly correlated with general adaptive functioning, social deficits and attentional problems. Our results suggest the neurobiological similarity and dissimilarity between NDDs need to be investigated beyond DSM/ICD-based, behaviourally-defined diagnostic categories.
Identifiants
pubmed: 33201803
pii: S2213-1582(20)30313-2
doi: 10.1016/j.nicl.2020.102476
pmc: PMC7649647
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
102476Informations de copyright
Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.
Références
Psychol Med. 2018 Nov;48(15):2515-2521
pubmed: 29415788
Front Neurosci. 2019 Jan 10;12:1018
pubmed: 30686984
Nat Rev Neurosci. 2006 Jun;7(6):464-76
pubmed: 16715055
Mol Autism. 2019 Jun 24;10:27
pubmed: 31285817
J Autism Dev Disord. 1994 Oct;24(5):659-85
pubmed: 7814313
Am J Psychiatry. 2018 Apr 1;175(4):359-369
pubmed: 29145754
Front Syst Neurosci. 2012 Sep 05;6:62
pubmed: 22973200
JAMA Psychiatry. 2015 Aug;72(8):767-77
pubmed: 26061743
Biol Psychiatry. 2013 Oct 15;74(8):623-32
pubmed: 23541632
Neuroimage Clin. 2015 Apr 09;8:238-45
pubmed: 26106547
Neuroimage. 2015 Nov 15;122:222-32
pubmed: 26241683
Hum Brain Mapp. 2014 Dec;35(12):6032-48
pubmed: 25116862
JAMA Netw Open. 2018 Nov 2;1(7):e184777
pubmed: 30646371
Am J Psychiatry. 2016 Sep 9;174(1):60-69
pubmed: 27609241
PLoS One. 2012;7(5):e36356
pubmed: 22570705
Neuroscience. 2017 Mar 14;345:243-255
pubmed: 27491478
Biol Psychiatry. 2021 Jan 15;89(2):172-183
pubmed: 32709415
Transl Psychiatry. 2019 Nov 26;9(1):318
pubmed: 31772171
Trends Cogn Sci. 2012 Jan;16(1):17-26
pubmed: 22169776
Neuroimage Clin. 2017 Apr 19;15:181-193
pubmed: 28529874
J Autism Dev Disord. 2000 Jun;30(3):205-23
pubmed: 11055457
Biol Psychiatry. 2019 Aug 15;86(4):315-326
pubmed: 31010580
Front Hum Neurosci. 2019 Feb 11;13:42
pubmed: 30804772
Biol Psychiatry Cogn Neurosci Neuroimaging. 2016 May;1(3):253-261
pubmed: 27713929
Proc Natl Acad Sci U S A. 2001 Sep 25;98(20):11680-5
pubmed: 11562488
Netw Neurosci. 2019 Feb 01;3(2):344-362
pubmed: 30793086
Lancet Psychiatry. 2019 Oct;6(10):819-829
pubmed: 31447415
Biol Psychiatry. 2017 Apr 15;81(8):708-717
pubmed: 27769568
Cereb Cortex. 2021 Jan 1;31(1):547-561
pubmed: 32909037
Brain Connect. 2019 Nov;9(9):673-691
pubmed: 31631690
Dev Cogn Neurosci. 2019 Apr;36:100630
pubmed: 30878549
Front Hum Neurosci. 2019 Feb 01;13:6
pubmed: 30774589
Mol Psychiatry. 2020 Dec;25(12):3178-3185
pubmed: 32355335
Diagnostics (Basel). 2019 Mar 21;9(1):
pubmed: 30901848
Hum Brain Mapp. 2014 Jun;35(6):2852-60
pubmed: 24123377
Br J Psychiatry. 2019 Jun;214(6):339-344
pubmed: 31088591
PLoS One. 2018 Apr 17;13(4):e0194856
pubmed: 29664902
J Am Acad Child Adolesc Psychiatry. 2014 Jul;53(7):761-70.e26
pubmed: 24954825
Nat Rev Neurosci. 2009 Mar;10(3):186-98
pubmed: 19190637
J Int Neuropsychol Soc. 2010 Nov;16(6):1064-76
pubmed: 20719043
Autism Res. 2019 Mar;12(3):384-400
pubmed: 30624021
J Am Acad Child Adolesc Psychiatry. 2016 Apr;55(4):310-318.e4
pubmed: 27015722
Neurosci Biobehav Rev. 2018 Apr;87:151-160
pubmed: 29410103
Transl Psychiatry. 2018 Jul 17;8(1):133
pubmed: 30018328
Psychol Med. 2019 Oct;49(13):2247-2255
pubmed: 30362446
Mol Psychiatry. 2014 Jun;19(6):659-67
pubmed: 23774715
NPJ Genom Med. 2019 Oct 7;4:26
pubmed: 31602316
Hum Mol Genet. 2014 May 15;23(10):2752-68
pubmed: 24381304
J Am Acad Child Adolesc Psychiatry. 2015 Jun;54(6):479-86.e1
pubmed: 26004663
Hum Brain Mapp. 2018 Aug;39(8):3127-3142
pubmed: 29602272
Front Neurosci. 2018 Nov 27;12:869
pubmed: 30542259
Can J Psychiatry. 2006 Apr;51(5):325-8
pubmed: 16986822
Dialogues Clin Neurosci. 2018 Jun;20(2):133-140
pubmed: 30250390
Mol Psychiatry. 2019 Oct;24(10):1435-1450
pubmed: 30617272
Sci Rep. 2019 Jun 21;9(1):9043
pubmed: 31227769
J Psychiatr Res. 2012 Sep;46(9):1146-52
pubmed: 22647523
Neuroimage Clin. 2018 Apr 13;19:320-330
pubmed: 30013915
Brain Res. 2019 Mar 1;1706:157-165
pubmed: 30392771
Toxics. 2015 Mar 23;3(1):89-129
pubmed: 29056653
J Child Psychol Psychiatry. 2001 Feb;42(2):241-51
pubmed: 11280420
J Psychiatr Res. 2016 Dec;83:37-46
pubmed: 27552532
J Am Acad Child Adolesc Psychiatry. 1997 Jun;36(6):844-52
pubmed: 9183141
Cereb Cortex. 2010 Dec;20(12):2852-62
pubmed: 20237243
Perspect Biol Med. 1969 Winter;12(2):298-312
pubmed: 4304823
Neuroimage. 2012 Feb 1;59(3):2142-54
pubmed: 22019881
Neuroimage. 2014 Apr 15;90:449-68
pubmed: 24389422
J Autism Dev Disord. 2015 Jan;45(1):192-202
pubmed: 25149176
Nat Rev Neurosci. 2013 Apr;14(4):278-91
pubmed: 23511908
J Neurophysiol. 2011 Sep;106(3):1125-65
pubmed: 21653723
Psychol Med. 2020 Oct;50(13):2240-2253
pubmed: 31530292
Cortex. 2012 Feb;48(2):194-215
pubmed: 21575934
Am J Psychiatry. 2016 Dec 1;173(12):1213-1222
pubmed: 27363509