Understanding complex dynamics of behavioral, neurochemical and transcriptomic changes induced by prolonged chronic unpredictable stress in zebrafish.

Animals Antidepressive Agents / pharmacology Anxiety / drug therapy Behavior, Animal / drug effects Brain / drug effects Disease Models, Animal Female Fluoxetine / pharmacology Male Stress, Psychological / drug therapy Transcriptome / drug effects Zebrafish / physiology

Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
17 11 2020
Historique:
received: 21 05 2020
accepted: 12 10 2020
entrez: 18 11 2020
pubmed: 19 11 2020
medline: 15 1 2021
Statut: epublish

Résumé

Stress-related neuropsychiatric disorders are widespread, debilitating and often treatment-resistant illnesses that represent an urgent unmet biomedical problem. Animal models of these disorders are widely used to study stress pathogenesis. A more recent and historically less utilized model organism, the zebrafish (Danio rerio), is a valuable tool in stress neuroscience research. Utilizing the 5-week chronic unpredictable stress (CUS) model, here we examined brain transcriptomic profiles and complex dynamic behavioral stress responses, as well as neurochemical alterations in adult zebrafish and their correction by chronic antidepressant, fluoxetine, treatment. Overall, CUS induced complex neurochemical and behavioral alterations in zebrafish, including stable anxiety-like behaviors and serotonin metabolism deficits. Chronic fluoxetine (0.1 mg/L for 11 days) rescued most of the observed behavioral and neurochemical responses. Finally, whole-genome brain transcriptomic analyses revealed altered expression of various CNS genes (partially rescued by chronic fluoxetine), including inflammation-, ubiquitin- and arrestin-related genes. Collectively, this supports zebrafish as a valuable translational tool to study stress-related pathogenesis, whose anxiety and serotonergic deficits parallel rodent and clinical studies, and genomic analyses implicate neuroinflammation, structural neuronal remodeling and arrestin/ubiquitin pathways in both stress pathogenesis and its potential therapy.

Identifiants

DOI: 10.1038/s41598-020-75855-3 PMID: 33203921 PMC: PMC7673038
pubmed: 33203921
doi: 10.1038/s41598-020-75855-3
pii: 10.1038/s41598-020-75855-3
pmc: PMC7673038
doi:

Substances chimiques

Antidepressive Agents 0
Fluoxetine 01K63SUP8D

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

19981

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Auteurs

Konstantin A Demin (KA)

Institute of Translational Biomedicine, St. Petersburg State University, University Emb. 7-9, Saint-Petersburg, Russia. deminkasci@gmail.com.
Institute of Experimental Medicine, Almazov National Medical Research Centre, Ministry of Healthcare of Russian Federation, Saint-Petersburg, Russia. deminkasci@gmail.com.

Anton M Lakstygal (AM)

Institute of Translational Biomedicine, St. Petersburg State University, University Emb. 7-9, Saint-Petersburg, Russia.

Nataliya A Krotova (NA)

Institute of Translational Biomedicine, St. Petersburg State University, University Emb. 7-9, Saint-Petersburg, Russia.
Institute of Experimental Medicine, Almazov National Medical Research Centre, Ministry of Healthcare of Russian Federation, Saint-Petersburg, Russia.

Alexey Masharsky (A)

Core Facility Centre for Molecular and Cell Technologies, St. Petersburg State University, Saint-Petersburg, Russia.

Natsuki Tagawa (N)

Department of Biophysics and Biochemistry, Graduate School of Science, University of Tokyo, Tokyo, Japan.

Maria V Chernysh (MV)

Institute of Translational Biomedicine, St. Petersburg State University, University Emb. 7-9, Saint-Petersburg, Russia.

Nikita P Ilyin (NP)

Institute of Translational Biomedicine, St. Petersburg State University, University Emb. 7-9, Saint-Petersburg, Russia.

Alexander S Taranov (AS)

Institute of Translational Biomedicine, St. Petersburg State University, University Emb. 7-9, Saint-Petersburg, Russia.

David S Galstyan (DS)

Institute of Translational Biomedicine, St. Petersburg State University, University Emb. 7-9, Saint-Petersburg, Russia.
Laboratory of Preclinical Bioscreening, Granov Russian Research Center of Radiology and Surgical Technologies, Ministry of Healthcare of Russian Federation, Pesochny, Russia.

Ksenia A Derzhavina (KA)

Institute of Experimental Medicine, Almazov National Medical Research Centre, Ministry of Healthcare of Russian Federation, Saint-Petersburg, Russia.

Nataliia A Levchenko (NA)

Institute of Translational Biomedicine, St. Petersburg State University, University Emb. 7-9, Saint-Petersburg, Russia.

Tatiana O Kolesnikova (TO)

Institute of Translational Biomedicine, St. Petersburg State University, University Emb. 7-9, Saint-Petersburg, Russia.

Mikael S Mor (MS)

Institute of Translational Biomedicine, St. Petersburg State University, University Emb. 7-9, Saint-Petersburg, Russia.

Marina L Vasyutina (ML)

Institute of Experimental Medicine, Almazov National Medical Research Centre, Ministry of Healthcare of Russian Federation, Saint-Petersburg, Russia.

Evgeniya V Efimova (EV)

Institute of Translational Biomedicine, St. Petersburg State University, University Emb. 7-9, Saint-Petersburg, Russia.

Nataliia Katolikova (N)

Institute of Translational Biomedicine, St. Petersburg State University, University Emb. 7-9, Saint-Petersburg, Russia.
Institute of Cytology RAS, Saint-Petersburg, Russia.

Andrey D Prjibelski (AD)

Center for Algorithmic Biotechnology, Institute of Translational Biomedicine, St. Petersburg State University, Saint-Petersburg, Russia.

Raul R Gainetdinov (RR)

Institute of Translational Biomedicine, St. Petersburg State University, University Emb. 7-9, Saint-Petersburg, Russia.

Murilo S de Abreu (MS)

University of Passo Fundo, Passo Fundo, Brazil.

Tamara G Amstislavskaya (TG)

Laboratory of Biopsychiatry, Scientific Research Institute of Physiology and Basic Medicine, Novosibirsk, Russia.
School of Medicine and Psychology, Novosibirsk State University, Novosibirsk, Russia.

Tatyana Strekalova (T)

Department of Psychiatry and Neuropsychology, Maastricht University, Maastricht, The Netherlands.
Laboratory of Psychiatric Neurobiology, Institute of Molecular Medicine, I.M. Sechenov First Moscow State Medical University, Moscow, Russia.
Division of Molecular Psychiatry, Centre of Mental Health, University of Würzburg, Würzburg, Germany.

Allan V Kalueff (AV)

School of Pharmacy, Southwest University, Chongqing, China. avkalueff@gmail.com.
Ural Federal University, Ekaterinburg, Russia. avkalueff@gmail.com.
Laboratory of Cell and Molecular Biology and Neurobiology, Moscow Institute of Physics and Technology, Dolgoprudny, Russia. avkalueff@gmail.com.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Understanding complex dynamics of behavioral,...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents du système nerveux central › Psychoanaleptiques › Antidépresseurs › Understanding complex dynamics of behavioral,...
questionsmedicales.fr › Comportement et mécanismes comportementaux › Émotions › Anxiété › Understanding complex dynamics of behavioral,...
questionsmedicales.fr › Comportement et mécanismes comportementaux › Comportement › Comportement animal › Understanding complex dynamics of behavioral,...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Understanding complex dynamics of behavioral,...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Understanding complex dynamics of behavioral,...
questionsmedicales.fr › Composés chimiques organiques › Amines › Propylamines › Fluoxétine › Understanding complex dynamics of behavioral,...
questionsmedicales.fr › Phénomènes psychologiques › Stress psychologique › Understanding complex dynamics of behavioral,...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Transcriptome › Understanding complex dynamics of behavioral,...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Poissons › Cypriniformes › Cyprinidae › Danio zébré › Understanding complex dynamics of behavioral,...