Recovery of Human Embryonic Stem Cells-Derived Neural Progenitors Exposed to Hypoxic-Ischemic-Reperfusion Injury by Indirect Exposure to Wharton's Jelly Mesenchymal Stem Cells Through Phosphatidyl-inositol-3-Kinase Pathway.
Glial progenitor population
In vitro HIE model
Intracellular calcium
Migration potential
Oxidative stress susceptibility
Oxygen glucose deprivation and reperfusion
PSA-NCAM
Proliferation
Umbilical cord-derived MSCs
Journal
Cellular and molecular neurobiology
ISSN: 1573-6830
Titre abrégé: Cell Mol Neurobiol
Pays: United States
ID NLM: 8200709
Informations de publication
Date de publication:
May 2022
May 2022
Historique:
received:
04
08
2020
accepted:
11
11
2020
pubmed:
19
11
2020
medline:
2
4
2022
entrez:
18
11
2020
Statut:
ppublish
Résumé
Increasing evidence suggests that mesenchymal stem cells(MSCs) have beneficial effects in hypoxic ischemic reperfusion injury, but the underlying mechanisms are unclear. Here, we first examined the effect of OGD reperfusion injury on the vulnerability of human NPs derived from human embryonic stem cells (hESCs) with regard to cell survival and oxidative stress. Cellular deregulation was assessed by measuring glutathione levels, basal calcium and intracellular calcium [Ca
Identifiants
pubmed: 33206286
doi: 10.1007/s10571-020-01007-w
pii: 10.1007/s10571-020-01007-w
doi:
Substances chimiques
Inositol
4L6452S749
Phosphatidylinositol 3-Kinase
EC 2.7.1.137
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1167-1188Subventions
Organisme : Council for Science and Industrial Research
ID : 37/(1614)/13/EMR-II
Informations de copyright
© 2020. Springer Science+Business Media, LLC, part of Springer Nature.
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