Cutaneous metastasis in a case of Wilm's tumor diagnosed on cytology - A rare case report.
Wilm's tumor
cutaneous metastasis
Journal
Diagnostic cytopathology
ISSN: 1097-0339
Titre abrégé: Diagn Cytopathol
Pays: United States
ID NLM: 8506895
Informations de publication
Date de publication:
Jun 2021
Jun 2021
Historique:
revised:
09
10
2020
received:
31
05
2020
accepted:
05
11
2020
pubmed:
19
11
2020
medline:
19
11
2021
entrez:
18
11
2020
Statut:
ppublish
Résumé
A 12-year-old male child presented with complaints of a slow growing swelling in the right parasternal region noticed since one month. On examination, the lump was 2 × 2 cm firm, mobile nontender located in the subcutaneous plane which was also confirmed radiologically. Fine needle aspiration cytology was attempted showed small to medium sized monotonous round cell morphology, nuclear molding and mitotic figures were frequent. Few cells exhibiting rosettoid arrangement. No definite epithelial or mesenchymal component was evident. No glio-fibrillary matrix or lymphoglandular bodies were evident in the smears. Based on morphology, a small round cell tumor was considered with possibilities of Wilm's tumor and Ewing's family of tumor. Based on morphological differentials ICC was requested, tumor cells were positive for strong nuclear WT1 staining while CK and FLI1 were negative. The cytomorphology along with the ICC confirmed the diagnosis of metastatic wilm's tumor. Seven years back, patient had a history of nephrectomy, which on histopathology was reported as triphasic Wilms tumor with favorable histology. Generally Wilm's tumor recurs within 2 years of diagnosis. Late recurrence in Wilm's tumor is rare with only a handful of case reports. Common sites for metastasis include lung, liver, contralateral kidney. Cutaneous metastasis is very uncommon, early detection of which with helps in therapeutic and prognostic decisions. The interesting aspect of this article is cytological detection of cutaneous metastasis of late recurrence Wilm's tumor, which is extremely rare to occur.
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
E190-E194Informations de copyright
© 2020 Wiley Periodicals LLC.
Références
Breslow N, Olshan A, Beckwith JB, Green DM. Epidemiology of Wilmstumor. Med Pediatriconcol. 1993;21(3):172-181.
Sauter ER, Schorin MA, Farr JG, Falterman KW, Arensman RM. Wilmstumor with metastasis to the left testis. Am Surg. 1990;56(4):260-262.
Radhakrishnan V, Mishra S, Raja A, Sundersingh S. Relapse of Wilms tumour after 20 years: a rare presentation and review of literature. Ediatric Hematol Oncol J. 2016;1(4):86-88.
Brownstein MH, Helwig EB. Patterns of cutaneous metastasis. Arch Dermatol. 1972;105(6):862-868.
Breslow NE, Norris R, Norkool PA, et al. Characteristics and outcomes of children with the Wilms tumor-Aniridia syndrome: a report from the National Wilms Tumor Study Group. J Clin Oncol. 2003;21:4579-4585.
Vujanić GM, Sandstedt B, Kelsey A, Sebire NJ. Central pathology review in multicenter trials and studies: lessons from the nephroblastoma trials. Cancer. 2009;115:1977-1983.
Nayak A, Iyer VK, Agarwala S. The cytomorphologic spectrum of Wilms tumour on fine needle aspiration: a single institutional experience of 110 cases. Cytopathology. 2011;22(1):50-59.
Schoenlaub P, Sarraux A, Grosshans E, Heide E, Cribier B. Survival after cutaneous metastasis: a study of 200 cases. Ann Dermatol Venereol. 2001;128(12):1310-1315.
Shet T, Viswanathan S. The cytological diagnosis of paediatric renal tumours. J Clin Pathol. 2009;62(11):961-969.
Bansal R, Patel T, Sarin J, Parikh B, Ohri A, Trivedi P. Cutaneous and subcutaneous metastasesfrom internal malignancies: an analysisof cases diagnosed by fine needle aspiration. DiagnCytopathol. 2011;39:882-887.
Aldret S, Cotton L. Skin as a site of metastasis. OsteopathFam Phys. 2012;4:13-17.
Looking bill DP, Spangler N, Sexton FM. Skin involvement as the presenting sign of internal carcinoma: a retrospective study of 7316 cancer patients. J Am Acad Dermatol. 1990;22(1):19-26.