H3K27M in Gliomas Causes a One-Step Decrease in H3K27 Methylation and Reduced Spreading within the Constraints of H3K36 Methylation.

Cell Line, Tumor Chromatin / genetics DNA Methylation / genetics Epigenomics Gene Expression / genetics Gene Expression Regulation, Neoplastic / genetics Glioma / genetics Histones / genetics Humans Lysine / metabolism Methionine / metabolism Methylation Mutation / genetics Polycomb Repressive Complex 2 / metabolism Protein Processing, Post-Translational
H3.3K27M computational modeling epigenomics histone methylation pediatric high-grade glioma

Journal

Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691

Informations de publication

Date de publication:
17 11 2020
Historique:
received: 29 04 2020
revised: 23 09 2020
accepted: 23 10 2020
entrez: 18 11 2020
pubmed: 19 11 2020
medline: 9 11 2021
Statut: ppublish

Résumé

The discovery of H3K27M mutations in pediatric gliomas marked a new chapter in cancer epigenomics. Numerous studies have investigated the effect of this mutation on H3K27 trimethylation, but only recently have we started to realize its additional effects on the epigenome. Here, we use isogenic glioma H3K27M

Identifiants

DOI: 10.1016/j.celrep.2020.108390 PMID: 33207202 PMC: PMC7703850
pubmed: 33207202
pii: S2211-1247(20)31379-6
doi: 10.1016/j.celrep.2020.108390
pmc: PMC7703850
mid: NIHMS1647627
pii:
doi:

Substances chimiques

Chromatin 0
Histones 0
Methionine AE28F7PNPL
Polycomb Repressive Complex 2 EC 2.1.1.43
Lysine K3Z4F929H6

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

108390

Subventions

Organisme : NCI NIH HHS
ID : P01 CA196539
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI118891
Pays : United States

Informations de copyright

Copyright © 2020 The Author(s). Published by Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Interests The authors declare no competing interests.

Références

Genes Dev. 2013 May 1;27(9):985-90
pubmed: 23603901
Mol Cell. 2011 May 6;42(3):330-41
pubmed: 21549310
J Biol Chem. 2011 Mar 11;286(10):7983-9
pubmed: 21239496
Elife. 2018 Jun 22;7:
pubmed: 29932419
Nat Commun. 2016 Apr 06;7:11185
pubmed: 27048880
Cancer Cell. 2017 May 8;31(5):635-652.e6
pubmed: 28434841
Nat Genet. 2012 Jan 29;44(3):251-3
pubmed: 22286216
Science. 2016 May 13;352(6287):844-9
pubmed: 27174990
Nature. 2012 Sep 6;489(7414):57-74
pubmed: 22955616
Nature. 2009 Oct 8;461(7265):762-7
pubmed: 19767730
Nat Biotechnol. 2011 Jan;29(1):24-6
pubmed: 21221095
Nat Rev Mol Cell Biol. 2012 Jan 23;13(2):115-26
pubmed: 22266761
Bioinformatics. 2010 Mar 15;26(6):841-2
pubmed: 20110278
Cell Rep. 2014 Nov 6;9(3):1163-70
pubmed: 25437568
Nat Rev Genet. 2014 Feb;15(2):93-106
pubmed: 24366184
Bioinformatics. 2009 Jul 15;25(14):1754-60
pubmed: 19451168
Acta Neuropathol. 2014 Nov;128(5):733-41
pubmed: 25200321
Acta Neuropathol. 2019 Apr;137(4):637-655
pubmed: 30770999
Bioinformatics. 2014 Apr 1;30(7):923-30
pubmed: 24227677
Mol Cell. 2014 Jan 9;53(1):49-62
pubmed: 24289921
Nucleic Acids Res. 2016 Jul 8;44(W1):W160-5
pubmed: 27079975
Nat Med. 2017 Apr;23(4):493-500
pubmed: 28263307
Science. 2013 May 17;340(6134):857-61
pubmed: 23539183
Methods Enzymol. 2016;574:3-29
pubmed: 27423855
Cell Rep. 2020 Jan 28;30(4):1223-1234.e8
pubmed: 31995760
Proc Natl Acad Sci U S A. 2019 Oct 29;116(44):22152-22157
pubmed: 31611394
Proc Natl Acad Sci U S A. 2012 Aug 21;109(34):13549-54
pubmed: 22869745
Nat Struct Mol Biol. 2018 Mar;25(3):225-232
pubmed: 29483650
Nature. 2019 Sep;573(7773):281-286
pubmed: 31485078
Nat Commun. 2016 Apr 28;7:11316
pubmed: 27121947
Mol Cell. 2018 Apr 19;70(2):371-379.e5
pubmed: 29606589
Cancer Cell. 2019 Jan 14;35(1):140-155.e7
pubmed: 30595505
Bioinformatics. 2013 Jan 1;29(1):15-21
pubmed: 23104886
Nature. 2017 Sep 14;549(7671):287-291
pubmed: 28869966
Nat Commun. 2019 Mar 19;10(1):1262
pubmed: 30890717
Acta Neuropathol. 2012 Sep;124(3):439-47
pubmed: 22661320
Sci Adv. 2018 Oct 31;4(10):eaau5935
pubmed: 30402543
Cancer Cell. 2013 Nov 11;24(5):660-72
pubmed: 24183680
Nat Med. 2017 Apr;23(4):483-492
pubmed: 28263309
Nature. 2015 Apr 9;520(7546):243-7
pubmed: 25607372
Nature. 2012 Jan 29;482(7384):226-31
pubmed: 22286061
Bioinformatics. 2009 Aug 15;25(16):2078-9
pubmed: 19505943
Cancer Cell. 2019 May 13;35(5):782-797.e8
pubmed: 31085178
Nat Protoc. 2013 Nov;8(11):2281-2308
pubmed: 24157548
Mol Cell. 2018 Jun 21;70(6):1149-1162.e5
pubmed: 29932905
Brief Bioinform. 2013 Mar;14(2):178-92
pubmed: 22517427
Cancer Cell. 2017 Nov 13;32(5):684-700.e9
pubmed: 29107533

Auteurs

Ashot S Harutyunyan (AS)

Department of Human Genetics, McGill University, Montreal, QC H3A 1B1, Canada; Department of Pediatrics, McGill University, Montreal, QC H4A 3J1, Canada; The Research Institute of the McGill University Health Centre, Montreal, QC H4A 3J1, Canada.

Haifen Chen (H)

Department of Human Genetics, McGill University, Montreal, QC H3A 1B1, Canada.

Tianyuan Lu (T)

Department of Human Genetics, McGill University, Montreal, QC H3A 1B1, Canada; Quantitative Life Sciences Program, McGill University, Montreal, QC H3A 2A7, Canada.

Cynthia Horth (C)

Department of Human Genetics, McGill University, Montreal, QC H3A 1B1, Canada.

Hamid Nikbakht (H)

Department of Human Genetics, McGill University, Montreal, QC H3A 1B1, Canada.

Brian Krug (B)

Department of Human Genetics, McGill University, Montreal, QC H3A 1B1, Canada.

Caterina Russo (C)

Department of Pediatrics, McGill University, Montreal, QC H4A 3J1, Canada; The Research Institute of the McGill University Health Centre, Montreal, QC H4A 3J1, Canada.

Eric Bareke (E)

Department of Human Genetics, McGill University, Montreal, QC H3A 1B1, Canada.

Dylan M Marchione (DM)

Department of Biochemistry and Biophysics and the Penn Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

Mariel Coradin (M)

Department of Biochemistry and Biophysics and the Penn Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

Benjamin A Garcia (BA)

Department of Biochemistry and Biophysics and the Penn Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

Nada Jabado (N)

Department of Human Genetics, McGill University, Montreal, QC H3A 1B1, Canada; Department of Pediatrics, McGill University, Montreal, QC H4A 3J1, Canada; The Research Institute of the McGill University Health Centre, Montreal, QC H4A 3J1, Canada. Electronic address: nada.jabado@mcgill.ca.

Jacek Majewski (J)

Department of Human Genetics, McGill University, Montreal, QC H3A 1B1, Canada; McGill Genome Centre, Montreal, QC H3A 0G1, Canada. Electronic address: jacek.majewski@mcgill.ca.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › H3K27M in Gliomas Causes a One-Step Decrease...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Structures de chromosome › Chromatine › H3K27M in Gliomas Causes a One-Step Decrease...
questionsmedicales.fr › Phénomènes génétiques › Méthylation de l'ADN › H3K27M in Gliomas Causes a One-Step Decrease...
questionsmedicales.fr › Disciplines des sciences naturelles › Disciplines des sciences biologiques › Biologie › Génétique › Génomique › Épigénomique › H3K27M in Gliomas Causes a One-Step Decrease...
questionsmedicales.fr › Phénomènes génétiques › Expression des gènes › H3K27M in Gliomas Causes a One-Step Decrease...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Régulation de l'expression des gènes tumoraux › H3K27M in Gliomas Causes a One-Step Decrease...
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs du tissu nerveux › Tumeurs neuroectodermiques › Tumeurs neuroépitheliales › Gliome › H3K27M in Gliomas Causes a One-Step Decrease...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Nucléoprotéines › Histone › H3K27M in Gliomas Causes a One-Step Decrease...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › H3K27M in Gliomas Causes a One-Step Decrease...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Acides aminés essentiels › Lysine › H3K27M in Gliomas Causes a One-Step Decrease...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Acides aminés soufrés › Méthionine › H3K27M in Gliomas Causes a One-Step Decrease...
questionsmedicales.fr › Métabolisme › Alkylation › Méthylation › H3K27M in Gliomas Causes a One-Step Decrease...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › H3K27M in Gliomas Causes a One-Step Decrease...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Protéines de répression › Protéines du groupe Polycomb › Complexe répresseur Polycomb-2 › H3K27M in Gliomas Causes a One-Step Decrease...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Modification traductionnelle des protéines › Maturation post-traductionnelle des protéines › H3K27M in Gliomas Causes a One-Step Decrease...