Imidazole propionate is increased in diabetes and associated with dietary patterns and altered microbial ecology.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
18 11 2020
18 11 2020
Historique:
received:
02
09
2019
accepted:
22
10
2020
entrez:
19
11
2020
pubmed:
20
11
2020
medline:
15
12
2020
Statut:
epublish
Résumé
Microbiota-host-diet interactions contribute to the development of metabolic diseases. Imidazole propionate is a novel microbially produced metabolite from histidine, which impairs glucose metabolism. Here, we show that subjects with prediabetes and diabetes in the MetaCardis cohort from three European countries have elevated serum imidazole propionate levels. Furthermore, imidazole propionate levels were increased in subjects with low bacterial gene richness and Bacteroides 2 enterotype, which have previously been associated with obesity. The Bacteroides 2 enterotype was also associated with increased abundance of the genes involved in imidazole propionate biosynthesis from dietary histidine. Since patients and controls did not differ in their histidine dietary intake, the elevated levels of imidazole propionate in type 2 diabetes likely reflects altered microbial metabolism of histidine, rather than histidine intake per se. Thus the microbiota may contribute to type 2 diabetes by generating imidazole propionate that can modulate host inflammation and metabolism.
Identifiants
pubmed: 33208748
doi: 10.1038/s41467-020-19589-w
pii: 10.1038/s41467-020-19589-w
pmc: PMC7676231
doi:
Substances chimiques
Imidazoles
0
5-imidazolepropionic acid
1074-59-5
Histidine
4QD397987E
Types de publication
Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
5881Subventions
Organisme : Department of Health
Pays : United Kingdom
Investigateurs
Renato Alves
(R)
Chloe Amouyal
(C)
Ehm Astrid Andersson Galijatovic
(EAA)
Olivier Barthelemy
(O)
Jean-Paul Batisse
(JP)
Magalie Berland
(M)
Randa Bittar
(R)
Hervé Blottière
(H)
Frederic Bosquet
(F)
Rachid Boubrit
(R)
Olivier Bourron
(O)
Mickael Camus
(M)
Dominique Cassuto
(D)
Julien Chilloux
(J)
Cecile Ciangura
(C)
Luis Pedro Coelho
(LP)
Jean-Philippe Collet
(JP)
Maria-Carlota Dao
(MC)
Morad Djebbar
(M)
Angélique Doré
(A)
Line Engelbrechtsen
(L)
Soraya Fellahi
(S)
Leopold Fezeu
(L)
Sebastien Fromentin
(S)
Philippe Giral
(P)
Jens Peter Gøtze
(JP)
Agnes Hartemann
(A)
Jens Juul Holst
(JJ)
Serge Hercberg
(S)
Gerard Helft
(G)
Malene Hornbak
(M)
Jean-Sebastien Hulot
(JS)
Richard Isnard
(R)
Sophie Jaqueminet
(S)
Niklas Rye Jørgensen
(NR)
Hanna Julienne
(H)
Johanne Justesen
(J)
Judith Kammer
(J)
Nikolaj Krarup
(N)
Mathieu Kerneis
(M)
Jean Khemis
(J)
Nadja Buus Kristensen
(NB)
Michael Kuhn
(M)
Véronique Lejard
(V)
Florence Levenez
(F)
Lea Lucas-Martini
(L)
Robin Massey
(R)
Nicolas Maziers
(N)
Jonathan Medina-Stamminger
(J)
Gilles Montalescot
(G)
Sandrine Moutel
(S)
Laetitia Pasero Le Pavin
(LP)
Christine Poitou
(C)
Francoise Pousset
(F)
Laurence Pouzoulet
(L)
Sebastien Schmidt
(S)
Lucas Moitinho-Silva
(L)
Johanne Silvain
(J)
Nataliya Sokolovska
(N)
Sothea Touch
(S)
Mathilde Svendstrup
(M)
Timothy Swartz
(T)
Thierry Vanduyvenboden
(T)
Camille Vatier
(C)
Stefanie Walther
(S)
Commentaires et corrections
Type : ErratumIn
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