Variance-based sensitivity analysis for uncertainties in proton therapy: A framework to assess the effect of simultaneous uncertainties in range, positioning, and RBE model predictions on RBE-weighted dose distributions.
proton therapy
range uncertainty
relative biological effectiveness
sensitivity analysis
uncertainty analysis
Journal
Medical physics
ISSN: 2473-4209
Titre abrégé: Med Phys
Pays: United States
ID NLM: 0425746
Informations de publication
Date de publication:
Feb 2021
Feb 2021
Historique:
received:
12
08
2019
revised:
20
10
2020
accepted:
11
11
2020
pubmed:
20
11
2020
medline:
15
5
2021
entrez:
19
11
2020
Statut:
ppublish
Résumé
Treatment plans in proton therapy are more sensitive to uncertainties than in conventional photon therapy. In addition to setup uncertainties, proton therapy is affected by uncertainties in proton range and relative biological effectiveness (RBE). While to date a constant RBE of 1.1 is commonly assumed, the actual RBE is known to increase toward the distal end of the spread-out Bragg peak. Several models for variable RBE predictions exist. We present a framework to evaluate the combined impact and interactions of setup, range, and RBE uncertainties in a comprehensive, variance-based sensitivity analysis (SA). The variance-based SA requires a large number (10 The approach is demonstrated for two representative brain tumor cases and a prostate case. The full SA including
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
805-818Subventions
Organisme : Deutsche Forschungsgemeinschaft (DFG)
ID : KA 4346/1-1
Organisme : Deutsche Forschungsgemeinschaft (DFG)
ID : DFG-MAP
Informations de copyright
© 2020 The Authors. Medical Physics published by Wiley Periodicals LLC on behalf of American Association of Physicists in Medicine.
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