Seasonal variation in biopsy-proven giant cell arteritis in Eastern Denmark from 1990-2018.


Journal

Acta ophthalmologica
ISSN: 1755-3768
Titre abrégé: Acta Ophthalmol
Pays: England
ID NLM: 101468102

Informations de publication

Date de publication:
Aug 2021
Historique:
revised: 01 10 2020
received: 08 05 2020
accepted: 11 10 2020
pubmed: 20 11 2020
medline: 15 12 2021
entrez: 19 11 2020
Statut: ppublish

Résumé

The purpose of this study was to investigate seasonal variation in cases of biopsy-proven GCA in eastern Denmark in a 29-year period. Pathology records of all temporal artery biopsies in eastern Denmark between 1990 and 2018 were reviewed. For each patient, data were collected which included age, sex, date of birth and biopsy result. Seasonality was evaluated using logistic regression and Poisson regression analysis. Lastly, an explorative pilot study was conducted to investigate a possible association between three weather parameters (average temperature, amount of rain and hours of sunshine) and the biopsy outcome. One thousand three hundred twenty-three biopsies were included of which 336 fulfilled objective criteria for GCA diagnosis. Mean age at diagnosis was 75.6 years (range 52-94 years). Among the biopsy-proven cases of GCA, there were 223 women (66.3%, mean age 76.2 years) and 113 men (33.7%, mean age 74.4 years) giving a female to male ratio of 1.97:1. The peak occurrence of GCA was in the 70-79 years age group. Statistical analysis of seasonal variation showed an increased risk of a positive biopsy during summer compared to autumn (p = 0.037). No association between the three weather parameters and the biopsy outcome was found. In this study of biopsy-proven GCA in a large Danish patient cohort, the occurrence of GCA showed seasonal variation with higher occurrence in the summer months when compared to autumn. Future studies pooling all cases of GCA worldwide are needed to determine seasonality in the occurrence of GCA.

Identifiants

pubmed: 33211398
doi: 10.1111/aos.14675
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

527-532

Informations de copyright

© 2020 Acta Ophthalmologica Scandinavica Foundation. Published by John Wiley & Sons Ltd.

Références

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Auteurs

Elisabeth Bay Kønig (EB)

Eye Pathology Section, Department of Pathology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.

Michael Stormly Hansen (M)

Department of Ophthalmology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.

Jonathan Foldager (J)

Department of Applied Mathematics and Computer Science, Technical University of Denmark, Copenhagen, Denmark.

Volkert Siersma (V)

The Research Unit for General Practice and Section of General Practice, Department of Public Health, University of Copenhagen, Copenhagen, Denmark.

Annika Loft (A)

Department of Clinical Physiology, Nuclear Medicine and PET, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.

Lene Terslev (L)

Department of Clinical Medicine, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark.

Uffe Møller Døhn (U)

Center for Rheumatology and Spine Diseases, Rigshospitalet, Copenhagen, Denmark.

Mads Radmer Jensen (M)

Department of Clinical Physiology and Nuclear Medicine, Bispebjerg Hospital, Copenhagen, Denmark.

Anne Katrine Wiencke (AK)

Department of Clinical Medicine Rigshospitalet, Copenhagen, Denmark.

Carsten Faber (C)

Department of Ophthalmology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.

Steffen Hamann (S)

Department of Ophthalmology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.

Steffen Heegaard (S)

Eye Pathology Section, Department of Pathology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Department of Ophthalmology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.

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