The role of cytochrome P450 (CYP) enzymes in hyperoxic lung injury.
CYP1A enzyme
CYP1B enzyme
CYP2A enzyme
CYP2E1 enzyme
CYP2J2 enzyme
CYP4A enzyme
CYP4F enzyme
cytochrome P450 (CYP) enzymes
hyperoxic lung injury
oxidative stress
Journal
Expert opinion on drug metabolism & toxicology
ISSN: 1744-7607
Titre abrégé: Expert Opin Drug Metab Toxicol
Pays: England
ID NLM: 101228422
Informations de publication
Date de publication:
Feb 2021
Feb 2021
Historique:
pubmed:
21
11
2020
medline:
16
4
2021
entrez:
20
11
2020
Statut:
ppublish
Résumé
Hyperoxic lung injury is a condition that can occur in patients in need of supplemental oxygen, such as premature infants with bronchopulmonary dysplasia or adults with acute respiratory distress syndrome. Cytochrome P450 (CYP) enzymes play critical roles in the metabolism of endogenous and exogenous compounds. Through their complex pathways, some subfamilies of these enzymes may contribute to or protect against hyperoxic lung injury. Oxidative stress from reactive oxygen species (ROS) production is most likely a major contributor of hyperoxic lung injury. CYP1A enzymes have been shown to protect against hyperoxic lung injury while CYP1B enzymes seem to contribute to it. CYP2J2 enzymes help protect against hyperoxic lung injury by triggering EET production, thereby, increasing antioxidant enzymes. The metabolism of arachidonic acid to ω-terminal hydroxyeicosatetraenoic acid (20-HETEs) by CYP4A and CYP4F enzymes could impact hyperoxic lung injury via the vasodilating effects of 20-HETE. CYP2E1 and CYP2A enzymes may contribute to the oxidative stress in the lungs caused by ethanol- and nicotine-metabolism, respectively. Overall, the CYP enzymes, depending upon the isoform, play a contributory or protective role in hyperoxic lung injury, and are, therefore, ideal candidates for developing drugs that can treat oxygen-mediated lung injury.
Identifiants
pubmed: 33215946
doi: 10.1080/17425255.2021.1853705
pmc: PMC7864879
mid: NIHMS1650217
doi:
Substances chimiques
Cytochrome P-450 Enzyme System
9035-51-2
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
171-178Subventions
Organisme : NIEHS NIH HHS
ID : R01 ES009132
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES019689
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL129794
Pays : United States
Organisme : NIEHS NIH HHS
ID : P42 ES027725
Pays : United States
Organisme : NIEHS NIH HHS
ID : P30 ES030285
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL144775
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES029382
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL070921
Pays : United States
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