Predictors of neonatal adiposity and associations by fetal sex in women with gestational diabetes mellitus and normal glucose-tolerant women.
Adiposity
/ physiology
Adolescent
Adult
Belgium
/ epidemiology
Birth Weight
/ physiology
C-Peptide
/ analysis
Cohort Studies
Diabetes, Gestational
/ blood
Female
Fetal Blood
/ chemistry
Fetal Macrosomia
/ blood
Fetus
/ metabolism
Humans
Infant, Newborn
Leptin
/ analysis
Lipids
/ analysis
Male
Middle Aged
Pregnancy
Pregnancy Outcome
Prognosis
Prospective Studies
Sex Characteristics
Skinfold Thickness
Young Adult
Cord blood
Fetal sex
Gestational diabetes mellitus
Neonatal adiposity
Overweight
Journal
Acta diabetologica
ISSN: 1432-5233
Titre abrégé: Acta Diabetol
Pays: Germany
ID NLM: 9200299
Informations de publication
Date de publication:
Mar 2021
Mar 2021
Historique:
received:
13
08
2020
accepted:
09
10
2020
pubmed:
21
11
2020
medline:
2
4
2021
entrez:
20
11
2020
Statut:
ppublish
Résumé
To determine predictors of neonatal adiposity and differences in associations by fetal sex in women with gestational diabetes mellitus (GDM), normal-weight and overweight (BMI ≥ 25 kg/m Skinfold thickness was measured in 576 newborns, and cord blood leptin, c-peptide and lipids in 327 newborns in a multi-centric prospective cohort study. Compared to neonates of normal-weight NGT women (327), neonates of women with GDM (97) were more often large-for-gestational age (LGA) (16.5% vs 8.6%, p = 0.024) ,but the macrosomia rate (8.2% vs 5.8%, p = 0.388), sum of skinfolds (13.9 mm ± 2.9 vs 13.3 mm ± 2.6, p = 0.067), neonatal fat mass (1333.0 g ± 166.8 vs 1307.3 g ± 160.9, p = 0.356), and cord blood biomarkers were not significantly different. Compared to neonates of normal-weight NGT women, neonates of overweight NGT women (152) had higher rates of macrosomia (12.5% vs 5.8%, p = 0.012), LGA (17.1% vs 8.6%, p = 0.006), higher sum of skinfolds (14.3 mm ± 2.6 vs 13.2 mm ± 2.6, p < 0.001), neonatal fat mass (1386.0 g ± 168.6 vs 1307.3 g ± 160.9, p < 0.001), % neonatal fat mass > 90th percentile (15.2% vs 7.1%, p < 0.001), without significant differences in cord blood biomarkers. Maternal BMI, fasting glycemia, triglycerides, gestational weight gain, cord blood leptin ,and cord blood triglycerides were independent predictors for neonatal adiposity. Gestational weight gain was positively associated with adiposity in boys only. Compared to neonates of normal-weight NGT women, neonates of GDM women have higher LGA rates but similar adiposity, while neonates of overweight NGT women have increased adiposity. Limiting gestational weight gain might be especially important in the male fetus to reduce neonatal adiposity.
Identifiants
pubmed: 33216207
doi: 10.1007/s00592-020-01619-0
pii: 10.1007/s00592-020-01619-0
doi:
Substances chimiques
C-Peptide
0
Leptin
0
Lipids
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
341-354Références
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