The amygdala instructs insular feedback for affective learning.
affective learning
amygdala
cholinergic basal forebrain
hierarchical interaction
insular cortex
interoceptive value
mouse
neuroscience
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
20 11 2020
20 11 2020
Historique:
received:
23
06
2020
accepted:
04
11
2020
entrez:
20
11
2020
pubmed:
21
11
2020
medline:
23
3
2021
Statut:
epublish
Résumé
Affective responses depend on assigning value to environmental predictors of threat or reward. Neuroanatomically, this affective value is encoded at both cortical and subcortical levels. However, the purpose of this distributed representation across functional hierarchies remains unclear. Using fMRI in mice, we mapped a discrete cortico-limbic loop between insular cortex (IC), central amygdala (CE), and nucleus basalis of Meynert (NBM), which decomposes the affective value of a conditioned stimulus (CS) into its salience and valence components. In IC, learning integrated unconditioned stimulus (US)-evoked bodily states into CS valence. In turn, CS salience in the CE recruited these CS representations bottom-up via the cholinergic NBM. This way, the CE incorporated interoceptive feedback from IC to improve discrimination of CS valence. Consequently, opto-/chemogenetic uncoupling of hierarchical information flow disrupted affective learning and conditioned responding. Dysfunctional interactions in the IC↔CE/NBM network may underlie intolerance to uncertainty, observed in autism and related psychiatric conditions.
Identifiants
pubmed: 33216712
doi: 10.7554/eLife.60336
pii: 60336
pmc: PMC7679142
doi:
pii:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : European Commission
ID : 311701
Pays : International
Organisme : Austrian Research Promotion Agency
ID : 852936
Pays : International
Organisme : Austrian Research Promotion Agency
ID : 854174
Pays : International
Informations de copyright
© 2020, Kargl et al.
Déclaration de conflit d'intérêts
DK, JK, SU, FG, LP, JL, KB, WH No competing interests declared
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