Receptor dynamics regulates actin polymerization state through phosphorylation of cofilin in mast cells.
Cofilin
F-actin
Hapten
Mast cell
Receptor dynamics
Journal
Biochemical and biophysical research communications
ISSN: 1090-2104
Titre abrégé: Biochem Biophys Res Commun
Pays: United States
ID NLM: 0372516
Informations de publication
Date de publication:
01 01 2021
01 01 2021
Historique:
received:
02
10
2020
accepted:
04
11
2020
pubmed:
22
11
2020
medline:
15
4
2021
entrez:
21
11
2020
Statut:
ppublish
Résumé
Aggregation of IgE bound to the high-affinity IgE receptor (FcεRI) by a multivalent antigen induces mast cell activation, while disaggregation of aggregated FcεRI by monomer hapten immediately terminates degranulation mediated by dephosphorylation of Syk and mediates a decrease in intracellular Ca
Identifiants
pubmed: 33218687
pii: S0006-291X(20)32056-8
doi: 10.1016/j.bbrc.2020.11.012
pii:
doi:
Substances chimiques
Actin Depolymerizing Factors
0
Actins
0
FCER1A protein, rat
0
Receptors, IgE
0
Rhodamines
0
trinitrophenyl-ovalbumin
0
Phalloidine
17466-45-4
Cytochalasin D
22144-77-0
Ovalbumin
9006-59-1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
714-719Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare that they have no conflicts of interest.