Ventricular assist device for a coronavirus disease 2019-affected heart.
COVID-19
Electron microscopy
Light sheet microscopy
SARS-CoV-2
Journal
ESC heart failure
ISSN: 2055-5822
Titre abrégé: ESC Heart Fail
Pays: England
ID NLM: 101669191
Informations de publication
Date de publication:
02 2021
02 2021
Historique:
received:
12
08
2020
revised:
06
10
2020
accepted:
02
11
2020
pubmed:
22
11
2020
medline:
6
3
2021
entrez:
21
11
2020
Statut:
ppublish
Résumé
Coronavirus disease 2019 (COVID-19) is challenging the care for cardiovascular patients, resulting in serious consequences with increasing mortality in pre-diseased heart failure patients. In the current state of the pandemic, the physiopathology of COVID-19 affecting pre-diseased hearts and the management of terminal heart failure in COVID-19 patients remain unclear. We outline the findings of a young COVID-19 patient suffering from idiopathic cardiomyopathy who was treated for acute multi-organ failure and required cardiac surgery with implantation of a temporary right ventricular and durable left ventricular assist device (LVAD). For deeper translational insights, we used in-depth tissue analysis by electron and light sheet fluorescence microscopy revealing evidence for spatial distribution of severe acute respiratory syndrome coronavirus 2 in the heart. This indicates that in-depth analysis may represent a valuable tool in understanding indistinct clinical cases. We conclude that COVID-19 directly affects pre-diseased hearts, but the consequences can be treated successfully with LVAD implantation.
Identifiants
pubmed: 33219613
doi: 10.1002/ehf2.13120
pmc: PMC7753611
doi:
Types de publication
Case Reports
Langues
eng
Sous-ensembles de citation
IM
Pagination
162-166Informations de copyright
© 2020 The Authors. ESC Heart Failure published by John Wiley & Sons Ltd on behalf of European Society of Cardiology.
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