Semisynthetic Vitamin E Derivatives as Potent Antibacterial Agents against Resistant Gram-Positive Pathogens.
Anti-Bacterial Agents
/ chemical synthesis
Dose-Response Relationship, Drug
Methicillin Resistance
/ drug effects
Microbial Sensitivity Tests
Molecular Structure
Staphylococcus aureus
/ drug effects
Staphylococcus epidermidis
/ drug effects
Structure-Activity Relationship
Vitamin E
/ analogs & derivatives
antibacterial agents
methicillin-resistant Staphylococcus aureus
natural products
semisynthesis
vitamin E
Journal
ChemMedChem
ISSN: 1860-7187
Titre abrégé: ChemMedChem
Pays: Germany
ID NLM: 101259013
Informations de publication
Date de publication:
03 03 2021
03 03 2021
Historique:
received:
09
10
2020
revised:
20
11
2020
pubmed:
22
11
2020
medline:
4
11
2021
entrez:
21
11
2020
Statut:
ppublish
Résumé
New 5-substituted vitamin E derivatives were semisynthesized, and their antibacterial activity against human Gram-positive and Gram-negative pathogens was evaluated. Several vitamin E analogues were active against methicillin-resistant Staphylococcus aureus (MRSA) and/or methicillin-resistant Staphylococcus epidermidis (MRSE); structure-activity relationships (SARs) are discussed. As a result, it is shown that the presence of a carboxylic acid function at the C-5 position and/or at the end of the side chain is crucial for the antibacterial activity. The bactericidal or bacteriostatic action of three compounds against MRSA and MRSE was confirmed in a time-kill kinetics study, and the cytotoxicity on human cells was evaluated. The preliminary mechanism study by confocal microscopy indicated that those vitamin E analogues led to bacterial cell death through membrane disruption.
Identifiants
pubmed: 33219748
doi: 10.1002/cmdc.202000792
doi:
Substances chimiques
Anti-Bacterial Agents
0
Vitamin E
1406-18-4
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
881-890Subventions
Organisme : Ministère de l'Enseignement Supérieur et de la Recherche
Organisme : Government of Syria
Informations de copyright
© 2020 Wiley-VCH GmbH.
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