IMT504 Provides Analgesia by Modulating Cell Infiltrate and Inflammatory Milieu in a Chronic Pain Model.
Complete Freund’s adjuvant (CFA)
Cytokines
IMT504
Lymphocytes
Oligonucleotide
Pain
Journal
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology
ISSN: 1557-1904
Titre abrégé: J Neuroimmune Pharmacol
Pays: United States
ID NLM: 101256586
Informations de publication
Date de publication:
09 2021
09 2021
Historique:
received:
02
09
2020
accepted:
11
11
2020
pubmed:
23
11
2020
medline:
18
1
2022
entrez:
22
11
2020
Statut:
ppublish
Résumé
IMT504 is a non-CPG, non-coding synthetic oligodeoxinucleotide (ODN) with immunomodulatory properties and a novel inhibitory role in pain transmission, exerting long-lasting analgesic effects upon multiple systemic administrations. However, its mechanisms of anti-nociceptive action are still poorly understood. In the present study in male adult rats undergoing complete Freund's adjuvant-induced hindpaw inflammation, we focused in the analysis of the immunomodulatory role of IMT504 over the cellular infiltrate, the impact on the inflammatory milieu, and the correlation with its anti-allodynic role. By means of behavioral analysis, we determined that a single subcutaneous administration of 6 mg/kg of IMT504 is sufficient to exert a 6-week-long full reversal of mechanical and cold allodynia, compromising neither acute pain perception nor locomotor activity. Importantly, we found that the anti-nociceptive effects of systemic IMT504, plus quick reductions in hindpaw edema, were associated with a modulatory action upon cellular infiltrate of B-cells, macrophages and CD8
Identifiants
pubmed: 33221983
doi: 10.1007/s11481-020-09971-2
pii: 10.1007/s11481-020-09971-2
doi:
Substances chimiques
IMT504
0
Oligodeoxyribonucleotides
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
651-666Informations de copyright
© 2020. Springer Science+Business Media, LLC, part of Springer Nature.
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