Urinary cadmium concentrations and risk of primary ovarian insufficiency in women: a case-control study.
Adult
Anti-Mullerian Hormone
/ blood
Biomarkers
/ urine
Cadmium
/ toxicity
Case-Control Studies
China
Environmental Exposure
/ adverse effects
Estradiol
/ blood
Female
Follicle Stimulating Hormone
/ blood
Humans
Luteinizing Hormone
/ blood
Middle Aged
Primary Ovarian Insufficiency
/ blood
Risk Factors
Young Adult
Cadmium
Female reproductive health
Heavy metal
Primary ovarian insufficiency
Reproductive hormones
Journal
Environmental geochemistry and health
ISSN: 1573-2983
Titre abrégé: Environ Geochem Health
Pays: Netherlands
ID NLM: 8903118
Informations de publication
Date de publication:
May 2021
May 2021
Historique:
received:
27
11
2019
accepted:
04
11
2020
pubmed:
23
11
2020
medline:
11
5
2021
entrez:
22
11
2020
Statut:
ppublish
Résumé
Cadmium, a toxic heavy metal that occurs in the environment in large quantities through human activities, has been shown to have adverse effects on female reproductive health. However, the association between cadmium exposure and primary ovarian insufficiency (POI), one of the most prevalent ovarian diseases in women, has not been examined yet. This case-control study involving 169 POI cases and 209 healthy controls was conducted in Zhejiang Province, China. The urinary concentrations of cadmium were determined by inductively coupled plasma mass spectrometry (ICP-MS). In addition, serum levels of reproductive hormones, including follicle-stimulating hormone (FSH), luteinizing hormone (LH), anti-Mullerian hormone (AMH) and estradiol, were measured. The median concentration of urinary cadmium in POI cases (0.43 μg/L, 0.58 μg/g for creatinine adjustment) was significantly higher than that of controls (0.29 μg/L, 0.43 μg/g for creatinine adjustment). The results of binary logistic regression models showed that the concentrations of urinary cadmium were positively significantly correlated with the odds ratio (ORs) of POI before the adjustment of confounders. After the adjustment, a significantly positive association was still present between the increased concentrations of cadmium and the ORs of POI (2.50, 95% CIs: 1.34-4.65 for the third tertile, p for trend = 0.001). The serum levels of FSH and LH were positively associated with urinary cadmium, while AMH and estradiol levels were inversely correlated. To the best of our knowledge, this is the first reported positive association of cadmium exposure with the risk of POI in women.
Identifiants
pubmed: 33222148
doi: 10.1007/s10653-020-00775-0
pii: 10.1007/s10653-020-00775-0
doi:
Substances chimiques
Biomarkers
0
Cadmium
00BH33GNGH
Estradiol
4TI98Z838E
Anti-Mullerian Hormone
80497-65-0
Luteinizing Hormone
9002-67-9
Follicle Stimulating Hormone
9002-68-0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2025-2035Subventions
Organisme : Fundamental Research Funds for the Central Universities
ID : 2019FZJD007
Organisme : National Natural Science Foundation of China
ID : 21876151
Organisme : National Natural Science Foundation of China
ID : 81703236
Organisme : Program for Key Subjects of Zhejiang Province in Medicine & Hygiene and Project for Zhejiang Medical Technology Program
ID : 2018KY437
Organisme : Program for Key Subjects of Zhejiang Province in Medicine & Hygiene and Project for Zhejiang Medical Technology Program
ID : WKJ-ZJ-1621
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