Novel quinazolin-sulfonamid derivatives: synthesis, characterization, biological evaluation, and molecular docking studies.

Acetylcholinesterase / chemistry Butyrylcholinesterase / chemistry Cholinesterase Inhibitors / chemistry Glycoside Hydrolases / metabolism Humans Molecular Docking Simulation Molecular Structure Structure-Activity Relationship
Quinazolin enzyme inhibition molecular docking sulfonamide

Journal

Journal of biomolecular structure & dynamics
ISSN: 1538-0254
Titre abrégé: J Biomol Struct Dyn
Pays: England
ID NLM: 8404176

Informations de publication

Date de publication:
05 2022
Historique:
pubmed: 24 11 2020
medline: 23 4 2022
entrez: 23 11 2020
Statut: ppublish

Résumé

In the design of novel drugs, the formation of hybrid molecules via the combination of several pharmacophores can give rise to compounds with interesting biochemical profiles. A series of novel quinazolin-sulfonamid derivatives (

Identifiants

DOI: 10.1080/07391102.2020.1847193 PMID: 33222620
pubmed: 33222620
doi: 10.1080/07391102.2020.1847193
doi:

Substances chimiques

Cholinesterase Inhibitors 0
Acetylcholinesterase EC 3.1.1.7
Butyrylcholinesterase EC 3.1.1.8
Glycoside Hydrolases EC 3.2.1.-

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

3359-3370

Auteurs

Nima Sepehri (N)

Nano Alvand Company, Avicenna Tech Park, Tehran University of Medical Sciences, Tehran, Iran.

Maryam Mohammadi-Khanaposhtani (M)

Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.

Nafise Asemanipoor (N)

Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.

Samanesadat Hosseini (S)

Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Mahmood Biglar (M)

Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.

Bagher Larijani (B)

Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.

Mohammad Mahdavi (M)

Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.

Haleh Hamedifar (H)

CinnaGen Medical Biotechnology Research Center, Alborz University of Medical Sciences, Karaj, Iran.

Parham Taslimi (P)

Department of Biotechnology, Faculty of Science, Bartin University, Bartin, Turkey.
ORCID: 0000-0002-3171-0633

Nastaran Sadeghian (N)

Department of Chemistry, Faculty of Science, Ataturk University, Erzurum, Turkey.

Mostafa Norizadehtazehkand (M)

Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Zonguldak Bulent Ecevit University, Zonguldak, Turkey.

Ilhami Gulcin (I)

Department of Chemistry, Faculty of Science, Ataturk University, Erzurum, Turkey.
ORCID: 0000-0001-5993-1668

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Classifications MeSH

questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Esterases › Carboxylic ester hydrolases › Cholinesterases › Acetylcholinesterase › Novel quinazolin-sulfonamid derivatives:...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Esterases › Carboxylic ester hydrolases › Cholinesterases › Butyrylcholine esterase › Novel quinazolin-sulfonamid derivatives:...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Agents neuromédiateurs › Agents cholinergiques › Anticholinestérasiques › Novel quinazolin-sulfonamid derivatives:...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Glycosidases › Novel quinazolin-sulfonamid derivatives:...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Novel quinazolin-sulfonamid derivatives:...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Simulation de docking moléculaire › Novel quinazolin-sulfonamid derivatives:...
questionsmedicales.fr › Phénomènes chimiques › Structure moléculaire › Novel quinazolin-sulfonamid derivatives:...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Relation structure-activité › Novel quinazolin-sulfonamid derivatives:...